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heme/lymph > signs > Flashcards

signs Flashcards

1
Q

Leukoerythroblastosis: Premature release of nucleated erythroid and early granulocyte precursors.

A

Primary Myelofibrosis (PM)

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2
Q

Graves disease, SLE, scleroderma, RA, and other AI disorders

A

thymic (follicular hyperplasia)

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3
Q

thymic/mediastinal mass

A

t- ALL (tcell acute lymphoblastic leukemia)

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4
Q

pulmonary lesions and destructive osteolytic bone lesions

A

-Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)

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5
Q

localized soft-tissue mass (myeloblastoma, granulocytic sarcoma/chloroma

A

AML

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6
Q

abs to GPIIb/IIIa, vWF

A

AML, NOS, M7

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7
Q

IgG and/or light chains (k) in urine and plasma

A 
multiple myeloma (plasma cell myeloma) 
-bence jones proteinurua
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8
Q

demyelinating dis of CNS

A

Adult T-cell Leukemia/Lymphoma

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9
Q

increased LFTs, TGs

A

Hemophagocytic Lymphohistocytosis (HLH)

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10
Q

normocytic, normochromic anemia +/- moderate leukopenia and thrombocytopenia.

A

multiple myeloma (plasma cell myeloma)

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11
Q

Thrombosis and hemorrhage d/t platelet dysfunction and increased number.
o DVT, portal and hepatic v. thrombosis, MI

A

-Polycythemia Vera (PCV or PV)
-Essential Thrombocytosis (ET)
Primary Myelofibrosis (PM)

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12
Q

RA, splenomegaly, neutropenia

A

Large Granular Lymphocytic Leukemia: felty synd

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13
Q

puritis

A

Polycythemia Vera (PCV or PV)

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14
Q

anemia

A
  • Hemophagocytic Lymphohistocytosis (HLH)
  • C/SLL (chronics,small lymphocytic leukemia) (from neoplastic Bcell autoabs)
  • Large Granular Lymphocytic Leukemia
  • AML
  • Primary Myelofibrosis (PM)
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15
Q

peptic ulcers

A

Polycythemia Vera (PCV or PV)

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16
Q

LNs enlarged, tender, fluctuant (moveable), and may form abscesses; red overlying skin

A

Acute Nonspecific Lymphadenitis

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17
Q

moth eaten vertebral column, ribs, skull, pelvis, femur, calvicle, scapula

A

multiple myeloma (plasma cell myeloma)

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18
Q

Mass of mandible/face and/or abdominal viscera (kidneys, ovaries, adrenals).

A

African (endemic) burkitt lymphoma

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19
Q

HepatoMegaly

A
  • Hemophagocytic Lymphohistocytosis (HLH)
  • C/SLL (chronics,small lymphocytic leukemia)
  • lymphoplasmacytic lymphoma
  • mamntle cell lymphoma (MCL)
  • Adult T-cell Leukemia/Lymphoma
  • AML, NOS, M5
  • Chronic Myelogenous Leukemia (CML)
  • spent phase of Polycythemia Vera (PCV or PV)
  • Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
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20
Q

spontaneous mucosal and cutaneous bleeding (gingiva, urinary tract); cutaneous petechiae and ecchymoses

A

AML

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21
Q

erythromelaglia

A 
Essential Thrombocytosis (ET)
=arteriole occlusion by platelet aggregates → burning and throbbing of hands and feet.
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22
Q

opportunistic infections of oral cavity, skin, lungs, kidneys, bladder, colon (fungi, Pseudomonas, commensals).

A

AML

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23
Q

PB:incrased megakaryocytes, platelses

A

Chronic Myelogenous Leukemia (CML)

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24
Q

PAS+

A

ALL (acute lymphoblastic leukemia)- d/t the lymphoblasts

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25
Q

seablue histiocytes

A

Chronic Myelogenous Leukemia (CML)

=mfs w wrinkled green-blue cyto

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26
Q

down synd

A

AML, NOS, M7

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27
Q

hypoparathyroidism and defects in cell-mediated immuity

A

DiGeorge synd: thymic hypoplasia/aplasia

28
Q

neutropenia

A
  • Large Granular Lymphocytic Leukemia

- AML

29
Q

thrombocytopenia

A
  • Hemophagocytic Lymphohistocytosis (HLH)
  • C/SLL (chronics,small lymphocytic leukemia)(from neoplastic Bcell autoabs)
  • AML (
30
Q

Lymphomatoid polyposis: if mucosal involvement of the small bowel or colon → polyps (can be misdiagnosed as ulcerative colitis).

A

mantle cell lymphoma (MCL)

31
Q

Leukocyte alkaline phosphatase (LAP) is high

A

reactive states, like infxn - worried about CML

32
Q

hyperCa

A

multiple myeloma (plasma cell myeloma)

33
Q

+ prussian blue stain

A

Myelodysplastic syndromes (MDS) (erythroid lineage: ring sideroblasts)

34
Q

hemophagocytosis on BM esam

A

Hemophagocytic Lymphohistocytosis (HLH)

35
Q

elevated platelets w/o polycythemia of marrow fibrosis

A

Essential Thrombocytosis (ET)

36
Q

mass of iliocecum an peritoneum

A

sporadic burkitt lymphoma

37
Q

Leukocytosis, exceeding 100,000 cells/mm^3

A

Chronic Myelogenous Leukemia (CML)

38
Q

Anemia, thrombocytopenia, recurrent infections (otitis media, mastoiditis)

A

-Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)

39
Q

MPO-

A

ALL (acute lymphoblastic leukemia) - d/t the lymphobalsts

40
Q

hyperuricemia/gout

A
  • Polycythemia Vera (PCV or PV)

- Primary Myelofibrosis (PM)

41
Q

iron deficiency

A

Polycythemia Vera (PCV or PV)

42
Q

increased blood viscosity and sludging

A

Polycythemia Vera (PCV or PV)

43
Q

Hand-schuller-christian Triad:

A

Multifocal Unisystem Langerhans Cell Histiocytosis

=Calvarial bone defects, DI, exopthalmos (scalp rash).

44
Q
  • Multiple erosive bone masses.
  • May extend into soft tissue.
  • May involve posterior pituitary stalk = diabetes insipidus (50%)
A

Multifocal Unisystem Langerhans Cell Histiocytosis

45
Q

Blasts are < 10% of circulating cells.

A

Chronic Myelogenous Leukemia (CML)

46
Q

if have sinus histiocytes…

A

look for CA (carcinoma of breats)

47
Q

look like appendicitis

A

mesenteric Acute Nonspecific Lymphadenitis

48
Q

paraneoplastic syndromes may be dx (hypogammaglobulinemia, pure red cell aplasia, Graves dis, pernicious anemia, dermatomyositis-polymyositis, Cushings)

49
Q

rheumatoid disorders

A

-Large Granular Lymphocytic Leukemia

50
Q

skin lesions, peripheral blood lymphocytosis, hypercalcemia

A

Adult T-cell Leukemia/Lymphoma

51
Q

splenomegaly

A
  • Hemophagocytic Lymphohistocytosis (HLH)
  • t- ALL (tcell acute lymphoblastic leukemia)- d/t the lymphoblasts
  • C/SLL (chronics,small lymphocytic leukemia)
  • lymphoplasmacytic lymphoma
  • mamntle cell lymphoma (MCL)
  • hairy cell leukemia ((MASSIVE))
  • Adult T-cell Leukemia/Lymphoma
  • Large Granular Lymphocytic Leukemia
  • AML, NOS, M5
  • Chronic Myelogenous Leukemia (CML)
  • spent phase of Polycythemia Vera (PCV or PV) - massive
  • Primary Myelofibrosis (PM)
  • Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
52
Q

Leukocyte alkaline phosphatase (LAP) is low

A

Chronic Myelogenous Leukemia (CML)

53
Q

LAD

A
  • t- ALL ( tcell acute lymphoblastic leukemia)- d/t the lymphoblasts
  • C/SLL (chronics,small lymphocytic leukemia)
  • follicular lymphoma
  • lymphoplasmacytic lymphoma
  • mamntle cell lymphoma (MCL)
  • Peripheral T-cell Lymphoma, Unspecified
  • Adult T-cell Leukemia/Lymphoma
  • all HL, generally painless LAD
  • Hodgkin Lymphoma: Lymphocyte Predominance Subtype
  • AML, NOS, M5
  • Chronic Myelogenous Leukemia (CML)
  • Multifocal Multisystem Langerhans Cell Histiocytosis (letterer-siwe Disease)
54
Q

solitary lesion of bone/st

A

solitary myeloma (plasmocytoma)

55
Q

pancytopenia

A

-hairy cell leukemia

56
Q

many bac infections

A
  • C/SLL (chronics,small lymphocytic leukemia) (d/t hypogammaglobulinemia)
  • multiple myeloma (plasma cell myeloma) (but not viral infections)
  • Primary Myelofibrosis (PM)
57
Q

kid with low platelet count

A

ALL (acute lymphoblastic leukemia) … until proven otherwise

58
Q

renal failure

A

multiple myeloma (plasma cell myeloma)

59
Q

decreased EPO

A

Polycythemia Vera (PCV or PV)

60
Q

high Hct
basophila
lg platlets

A

Polycythemia Vera (PCV or PV)

61
Q

rituculin

A
  • AML, NOS, M7

- Chronic Myelogenous Leukemia (CML)

62
Q

waldeyer ring involvement

A

DLBCL (diffuse large B cell lymphoma)

63
Q

puritis, eosinophilia, fever, wt loss

A

Peripheral T-cell Lymphoma, Unspecified

64
Q

diffuse demineralization (osteopenia)

A

multiple myeloma (plasma cell myeloma)

65
Q

organomegaly

A
  • Polycythemia Vera (PCV or PV)

- Essential Thrombocytosis (ET)

heme/lymph (18 decks)

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