immunophenotype

Question 1

HLA-DR, S100, CD1a (+)

Answer 1

Langerhans Cell Histiocytosis

Question 2

NNon-specific esterase only

Answer 2

AML, NOS, M5

Question 3

myeloid antigens

Answer 3

AML, NOS, M0

Question 4

TdT+

Answer 4

ALL (acute lymphoblastic leukemia)

Question 5

CLA
CR4
CCR10

Answer 5

Mycosis Fungoides & Sezary Syndrome

Question 6

CD 5, 19, 20, 23 (+)

Answer 6

C/SLL (chronics,small lymphocytic leukemia)

Question 7

CD30

Answer 7

Anaplastic Large Cell Lymphoma

Question 8

CD20 (+)
Surface Ig (+) (IgM)

Answer 8

lymphoplasmacytic lymphoma

Question 9

CD 10, 19, 20 (+)
BCL6 (+)
Surface IgM (+)
BCL2 (-)*
C-MYC (+)*

Answer 9

burkitt lymphoma

Question 10

CD19, PAX5, CD10 (- if immature), CD20 and IgM (in late)

Answer 10

B-ALLs

Question 11

CD 19, 20 (+)
Variable expression of CD10 and BCL6.
Most have surface Ig.

Answer 11

DLBCL (diffuse large B cell lymphoma)

Question 12

No CD21 (B-cell EBV receptor)
No CD3
No TCR rearrangements
Express NK cell markers

Answer 12

Extranodal NK/T-cell Lymphoma

Question 13

MPO

Non-specific esterase

Answer 13

AML, NOS, M4 (AMML)

Question 14

CD 2, 3, 5 and either αβ or γδ TCRs

Answer 14

Peripheral T-cell Lymphoma, Unspecified

Question 15

CD3

Answer 15

Large Granular Lymphocytic Leukemia: T-cell variant

Question 16

Low levels of surface Ig (IgM +/ IgD)

Answer 16

C/SLL (chronics,small lymphocytic leukemia)

Question 17

CD138 (+) (syndecan-1).
May be CD56 (+).
Have monoclonal spikes: only IgG and k

Answer 17

multiple myeloma (plasma cell myeloma)

Question 18

CD20, BCL6 (unique).

No CD 15, 30

Answer 18

Hodgkin Lymphoma: Lymphocyte Predominance Subtype

Question 19

Increased cyclin D1
CD 5, 19, 20 (+)
CD 23 (-).
Elevated surface Ig (usually IgM and IgD with κ or λ light chain)
IgH lacks somatic hypermutation

Answer 19

mantle cell lymphoma (MCL)

Question 20

CD1, CD2, CD5, CD7

–CD3, CD4, CD8: - in immature, + in mature

Answer 20

T-ALLs

Question 21

MPO

CD34 , 64, 3, 15

Answer 21

AML, NOS, M1

Question 22

CD 10, 19, 20 (+)
CD5 (-)
BCL6 (+) 
BCL2 (+) 
Surface Ig (+)

Answer 22

follicular lymphoma

Question 23

CD 11c, 19, 20, 25, 103 (+)
Annexin A1
Surface Ig (IgG) (+)

Answer 23

hairy cell leukemia

Question 24

CD56

Answer 24

Large Granular Lymphocytic Leukemia: NK-cell variant

Question 25

PAX5 (+)

CD 15, 30 (+)

Answer 25

Hodgkins lymphana classical type:
o	Nodular sclerosis 
o	Mixed cellularity 
o	Lymphocyte rich 
o	Lymphocyte depleted

Question 26

CCR6, CCR7

Answer 26

Immunophenotype of Langerhans cell histiocytosis