immunophenotype Flashcards

1
Q

HLA-DR, S100, CD1a (+)

A

Langerhans Cell Histiocytosis

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2
Q

NNon-specific esterase only

A

AML, NOS, M5

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3
Q

myeloid antigens

A

AML, NOS, M0

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4
Q

TdT+

A

ALL (acute lymphoblastic leukemia)

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5
Q

CLA
CR4
CCR10

A

Mycosis Fungoides & Sezary Syndrome

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6
Q

CD 5, 19, 20, 23 (+)

A

C/SLL (chronics,small lymphocytic leukemia)

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7
Q

CD30

A

Anaplastic Large Cell Lymphoma

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8
Q
CD20 (+)
Surface Ig (+) (IgM)
A

lymphoplasmacytic lymphoma

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9
Q
CD 10, 19, 20 (+)
BCL6 (+)
Surface IgM (+)
BCL2 (-)*
C-MYC (+)*
A

burkitt lymphoma

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10
Q

CD19, PAX5, CD10 (- if immature), CD20 and IgM (in late)

A

B-ALLs

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11
Q

CD 19, 20 (+)
Variable expression of CD10 and BCL6.
Most have surface Ig.

A

DLBCL (diffuse large B cell lymphoma)

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12
Q

No CD21 (B-cell EBV receptor)
No CD3
No TCR rearrangements
Express NK cell markers

A

Extranodal NK/T-cell Lymphoma

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13
Q

MPO

Non-specific esterase

A

AML, NOS, M4 (AMML)

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14
Q

CD 2, 3, 5 and either αβ or γδ TCRs

A

Peripheral T-cell Lymphoma, Unspecified

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15
Q

CD3

A

Large Granular Lymphocytic Leukemia: T-cell variant

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16
Q

Low levels of surface Ig (IgM +/ IgD)

A

C/SLL (chronics,small lymphocytic leukemia)

17
Q

CD138 (+) (syndecan-1).
May be CD56 (+).
Have monoclonal spikes: only IgG and k

A

multiple myeloma (plasma cell myeloma)

18
Q

CD20, BCL6 (unique).

No CD 15, 30

A

Hodgkin Lymphoma: Lymphocyte Predominance Subtype

19
Q
Increased cyclin D1
CD 5, 19, 20 (+)
CD 23 (-).
Elevated surface Ig (usually IgM and IgD with κ or λ light chain)
IgH lacks somatic hypermutation
A

mantle cell lymphoma (MCL)

20
Q

CD1, CD2, CD5, CD7

–CD3, CD4, CD8: - in immature, + in mature

A

T-ALLs

21
Q

MPO

CD34 , 64, 3, 15

A

AML, NOS, M1

22
Q
CD 10, 19, 20 (+)
CD5 (-)
BCL6 (+) 
BCL2 (+) 
Surface Ig (+)
A

follicular lymphoma

23
Q

CD 11c, 19, 20, 25, 103 (+)
Annexin A1
Surface Ig (IgG) (+)

A

hairy cell leukemia

24
Q

CD56

A

Large Granular Lymphocytic Leukemia: NK-cell variant

25
Q

PAX5 (+)

CD 15, 30 (+)

A
Hodgkins lymphana classical type:
o	Nodular sclerosis 
o	Mixed cellularity 
o	Lymphocyte rich 
o	Lymphocyte depleted
26
Q

CCR6, CCR7

A

Immunophenotype of Langerhans cell histiocytosis