14 prognosis Flashcards

1
Q

hereditary spherocytosis (HS)

A

-increased risk sepsis

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2
Q

sickle cell anemia

A
  • in kids: autosplenectomy

- 90% survive to age 20, 50% survive to 50+.

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3
Q

B thalassemai major

A
  • if chronic transfusinos, til 20s

- if no tx, early death d/t anemia

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4
Q

Paroxysmal Nocturnal Hemoglobinuria (PNH)

A
  • Leading COD: Venous thrombosis (40%) of the hepatic, portal or cerebral vv.’s
  • 5-10% develop acute myeloid leukemia (AML) or myelodysplastic syndrome.
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5
Q

pernicious anemia

A

-Atrophy and metaplasia of gastric mucosa.
-Increased risk of gastric carcinoma, with no change in risk after Tx.
-Risk of atherosclerosis and thrombosis.
-Increased homocysteine.
-Neuro disease is due to accumulation of methylmalonic acid in the spinal cord.
o Parenteral or high dose B12 cures the anemia and will halt or reverse the peripheral neurologic disease.

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