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morph Flashcards

1
Q

Toxic granulations: coarse, dark, abnormal azurophilic (primary) neutrophilic granules

A

sepsis/severe inflamm –> leukocytosis

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2
Q

Dohle bodies: patches of dilated ER seen as sky-blue cytoplasmic puddles

A

sepsis/severe inflamm –> leukocytosis

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3
Q

LNs:

  • Large germinal centers with numerous mitotic figures.
  • Nodes are swollen, gray-red and engorged
  • Endothelial cell hyperplasia (lining the sinus).
A

Acute Nonspecific Lymphadenitis

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4
Q

centeroblasts

A

Chronic Nonspecific Lymphadenitis: follicular hyperplasia (dark)

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5
Q

cernteocytes

A

Chronic Nonspecific Lymphadenitis: follicular hyperplasia (light)

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6
Q

Tingible-body MF

A

Chronic Nonspecific Lymphadenitis: follicular hyperplasia

o Contain the nuclear debris of B cells

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7
Q

immunobalsts

A

Chronic Nonspecific Lymphadenitis: paracortical hyperplasia

-Activated T cells 3-4 times the size of resting lymphocytes

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8
Q

marrow hypercelular w lymphobalsts

A

ALL (acute lymphoblastic leukemia)

-condensed chromatin, less prominent nucleoli, cyto w/o granules

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9
Q

LN archetectural effacement

A
  • C/SLL (chronics,small lymphocytic leukemia)

- follicular lymphoma

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10
Q

LN Proliferation centers Larger lymphocytes gathered in loose aggregates that contain mitotically active cells*

A

C/SLL (chronics,small lymphocytic leukemia)

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11
Q

Smudge cells

A

C/SLL (chronics,small lymphocytic leukemia)

-Small round lymphocytes in the peripheral blood with scant cytoplasm, disrupted when making the smear.

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12
Q

high mititc index; apop; starry sky pattern d/t phagocytosis of nuclear remnants by mf

A

Burkitt lymphoma

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13
Q

centrocytes

A

follicular lymphoma

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14
Q

centroblasts

A

follicular lymphoma

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15
Q

paratrabecular lymphoid aggregates

A

follicular lymphoma

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16
Q

Rouleaux formation

A 
multiple myeloma (plasma cell myeloma)
=plasma cell: increased M protein causes RBCs to stick together linearly in blood smears, indicative, but not specific.
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17
Q

Flame cells

A 
multiple myeloma (plasma cell myeloma)
=plasma cell: intracellular accumulation of degraded protein with fiery red cytoplasm
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18
Q

Mott cells

A 
multiple myeloma (plasma cell myeloma)
=plasma cell: multiple grapelike cytoplasmic droplets
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19
Q

Russel inclusions

A

-multiple myeloma (plasma cell myeloma)
-lymphoplasmacytic lymphoma
= plasma cell: PAS+ cytoplasmic globules

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20
Q

Dutcher inclusinos

A

-multiple myeloma (plasma cell myeloma)
-lymphoplasmacytic lymphoma:
=plasma cell: PAS+ nuclear globules

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21
Q

Heavily infiltrated splenic red pulp = obliteration of white pulp w a beefy red gross appearance.

A

hairy cell leukemia

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22
Q

effaced LNs; mix of variably sized malig T-cells w eos and mfs and neoangiogenesis

A

Peripheral T-cell Lymphoma, Unspecified

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23
Q
  • hallmark cells: anaplastic cells with horseshoe nuclei and voluminous cytoplasm
  • tumor cells surround venules, infiltrating lymphoid sinuses
A

Anaplastic Large Cell Lymphoma

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24
Q

multi-lobated nuclei (‘cloverleaf’ or ‘flower’ cells)

A

Adult T-cell Leukemia/Lymphoma

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25
Q

Epidermis and upper dermis are infiltrated by neoplastic T cells with a cerebriform appearance.

A

Mycosis Fungoides

26
Q

gneneralized exfoliative erythroderma

A

Sezary Syndrome

27
Q

leukemia of cells with characteristic cerebriform nuclei

A

Sezary Syndrome

28
Q

Large lymphocytes with abundant blue cytoplasm and azurophilic granules.

A

Large Granular Lymphocytic Leukemia

29
Q

destructive nasopharyngeal mass

A

Extranodal NK/T-cell Lymphoma

30
Q

invades small vessels –> ischemic necrosis

A

Extranodal NK/T-cell Lymphoma

31
Q

Large azurophilic granules in tumor cell cytoplasm.

A

Extranodal NK/T-cell Lymphoma

32
Q

Large, aneuploid B cells with multiple nuclei or a single nucleus with multiple lobes and inclusion-like nucleolus and Clearing around the nucleoli

AND single round or oblong nucleus with large inclusion like-nucleolus

A

mononuclear variant of RS cell

33
Q

Large, aneuploid B cells with multiple nuclei or a single nucleus with multiple lobes and inclusion-like nucleolus and Clearing around the nucleoli

AND delicate, folded or multilobate nuclei and Abundant pale cytoplasm that retracts during tissue processing = nucleus in an empty hole

A

lacunar variant of RS cell

34
Q

cell shrinking and becomoing pynknotic

A

dying (mummicifation) of RS cell

35
Q

Large, aneuploid B cells with multiple nuclei or a single nucleus with multiple lobes and inclusion-like nucleolus and Clearing around the nucleoli

AND multilobed nucei: “popcorm cells”

A

lymphohistiocytic variant of RS cell

36
Q

lacunar variant RS cells

A

Hodgkin Lymphoma: Nodular Sclerosis Subtype

37
Q
  • collagen bands that divide LNs into circumscribed nodules.

- Often involves cervical, supraclavicular and mediastinal LNs

A

Hodgkin Lymphoma: Nodular Sclerosis Subtype

38
Q

mononuclear variant RS cells

A

Hodgkin Lymphoma: Mixed cellularity Subtype

39
Q

lymphohistiocytic variant of RS cell

A
  • Hodgkin Lymphoma: Lymphocyte Depletion Subtype

- Hodgkin Lymphoma: Lymphocyte Predominance Subtype

40
Q

aeur rods

A
  • AML, NOS M2, M3

- AML w genetic abrrs

41
Q

Ring sideroblasts

A 
Myelodysplastic syndromes (MDS) (erythroid effect)
=Erythroblasts with iron laden mitochondria visible as perinuclear granules
42
Q

Neutrophils with Decreased secondary granules, toxic granulations or Dohle bodies

A

Myelodysplastic syndromes (MDS) (Granulocyte Lineage Effects)

43
Q

Pseudo-pelger-huet cells

A 
Myelodysplastic syndromes (MDS) (Granulocyte Lineage Effects)
=Neutrophils with only 2 nuclear lobes
44
Q

Cells with single nuclear lobes or multiple separate nuclei (‘pawn ball’)

A

Myelodysplastic syndromes (MDS) (Megakaryocytic Lineage Effects)

45
Q

hypercellular marrow: basophilia, eosinophila

A

Chronic Myelogenous Leukemia (CML)

46
Q

hypercellular marrow w residual fat

A

Polycythemia Vera (PCV or PV)

47
Q

obliterate fibrosis of marrow

A

spent phase of Polycythemia Vera (PCV or PV)

48
Q

cloudlike clusters of megakaryocytes

A

late Primary Myelofibrosis (PM)

49
Q

osteosclerosis

A

late Primary Myelofibrosis (PM)

50
Q

Dacryocytes

A 
Primary Myelofibrosis (PM)
-Tear drop shaped cells damaged during release from the fibrotic marrow.
51
Q

o Abundant, vacuolated cytoplasm
o Vesicular nuclei with linear grooves or folds
o *Birbeck granules:

A

Langerhans Cell Histiocytosis

=pantalaminar tubules w dilated terminal end (‘tennis racket’ appearance) *contain langerin.

52
Q

proliferation of Langerhans cells in medullary cavity of bone typically in the calvarium, ribs, femur.

A

Unifocal Unisystem Langerhans Cell Histiocytosis (eosinophilic granuloma)

53
Q

nodules and cysts in middle/upper lobes

A

Pulmonary Langerhans Cell Histiocytosis

54
Q

o Enlarged and soft spleen.
o Acute congestion of the red pulp => encroach on and efface lymphoid follicles.
o Infiltrates of nfs, plasma cells, +/- eos

A

Nonspecific Acute Splenitis

55
Q 
spleen:
o	Cut surface is gray-red to deep red.
o	Firm.
o	Thick, fibrous capsule.
o	Red pulp: congested then fibrotic.
o	Becomes fibrous and cellular if long-standing and mineral/pigment deposition too
A

congestive splenomegaly

56
Q

spleen:Bland: pale, wedge shaped, subcapsular, fibrous capsule

A

splenic infarct

57
Q

spleen: suppurative necrosis that leads to depressed scars.

A

splenic infarct: septic

58
Q

Hassall corpuscles (whorled) with keratinized cores. (squamous cells)

A

thymic epithelial cells

59
Q

B germinal centers in thymus

A

thymic (follicular) hyperplasia

60
Q

thymic cells: : elongated/spindle shaped; swirling, bland oval nuclei w inconspicuous nucleoli

A

medullary type epithelial cells: noninvasive thymoma

61
Q

thymic cells:
Cells are usually cortical with abundant cytoplasm and round, vesicular nuclei.
o Numerous reactive lympohoid cells
o Capsular invasive

A

cortical type cells: Invasive (malignant) Thymoma: (but cytologically benign)

heme/lymph (18 decks)

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