SIADH Flashcards
1
Q
Pathophysiology of SIADH?
A
Osmosis
2
Q
Clinical features of SIADH?
A
N V irritability
Confusion coma fits (cerebral edema due to low sodium)
< 125 mild symptoms
< 115 serious manifestations
3
Q
Aetiology of SIADH?
A
Tumours Almost all lung causes All the brain conditions Sx Fhx alchohol withdrawal Drugs (carbamazepine,chlorpropamide,cyclophosphamide)
4
Q
Dx of SIADH?
A
- dilutional hyponatremia
- low plasma osmolality with inappropriate urine osmolality > 100 mosm/kg
- Na excretion > 30 mmol/l
- N potassium bp adrenal renal and thyroid function
5
Q
Tx?
A
- underlying cause
- Restrictions of fluid intake
- Demecloyclin 600-1200 mg daily (inhibit ADH in kidney )
- If severe hypertonic saline
Chronic hyponatremia hv to be corrected slowly (max 10/day) otherwise will cause central pontine myelinolysis (osmotic demyelination) causing quadriplegia