SIADH Flashcards

1
Q

Pathophysiology of SIADH?

A

Osmosis

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2
Q

Clinical features of SIADH?

A

N V irritability
Confusion coma fits (cerebral edema due to low sodium)
< 125 mild symptoms
< 115 serious manifestations

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3
Q

Aetiology of SIADH?

A
Tumours
Almost all lung causes 
All the brain conditions
Sx
Fhx
alchohol withdrawal 
Drugs (carbamazepine,chlorpropamide,cyclophosphamide)
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4
Q

Dx of SIADH?

A
  1. dilutional hyponatremia
  2. low plasma osmolality with inappropriate urine osmolality > 100 mosm/kg
  3. Na excretion > 30 mmol/l
  4. N potassium bp adrenal renal and thyroid function
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5
Q

Tx?

A
  1. underlying cause
  2. Restrictions of fluid intake
  3. Demecloyclin 600-1200 mg daily (inhibit ADH in kidney )
  4. If severe hypertonic saline

Chronic hyponatremia hv to be corrected slowly (max 10/day) otherwise will cause central pontine myelinolysis (osmotic demyelination) causing quadriplegia

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