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Medicine > Hyperprolactinaemia > Flashcards

Hyperprolactinaemia Flashcards

1
Q

Pathophysiology?

A

TRH +
DOPAMIN -
+ BREAST,LACTATION
- OVARIES,ESTROGEN

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2
Q

Physiological causes?

A

Preg, lactation, srvere stress, sleep, coitus

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3
Q

Causes?

A
  1. prolactinoma
  2. co secretion of prolactin in tumours causing acromegaly
  3. stalk compression
  4. PCOS
  5. Iry hypothyroidism
  6. oestrogen tx
  7. RF
  8. LF
  9. dopamine antagonist (metachlopromide,domperidone,antipsychotic)
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4
Q

Clinical features?

A 
Galactorrhea
Oligomenorrhea, amenorrhea 
Decrease libido
Sub fertility 
Symptoms of oestrogen and androgen def
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5
Q

Ix?

A 
Visual fields 
Exclude hypothyroidism and hypopitutarism
MRI pitutary 
> 5000 macrosdenoma of > 10 mm diameter 
>2000 micro
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6
Q

Tx?

A

Dopamine agonist (cabergoline,bromacriptine)
Transphenoidal sx
Radiotherapy
Avoid effects of oes and testosterone def

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Medicine (38 decks)

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