Gigantism And Acromagaly

Question 1

Difference?

Answer 1

Gigantism in children if acquired before epiphysial fusion and acromegaly in adults

Question 2

Pathophysiology?

Answer 2

Osmosis

Question 3

Symptoms and signs?

Answer 3

Symptoms-
Change in appearance 
Hheadache
Excessive sweating 
Sleep apnea
Visual disturbance 
Amenorrhea 
Galactorrhea
Polyuria/poludypsia
Carpel tunnel syndrome 

Signs-prominent supraorbital ridge
Prognathism
Interdental separation 
Spade like hand and feet
Tight rings

Question 4

Ix?

Answer 4

1. ^ GH levels (not used)
2. OGTT- no supresses GH (diagnostic test)
3. ^ Insulin like growth hormone (screening te#t)
4. visual fields-bitemporal hemianopia
5. MRI pitutary
6. prolactin ^ in 30%

Question 5

Mx?

Answer 5

Tx for all except elderly and min abnormalities
1.sx- transphenoidal
2,pitutary radiotherapy
3.med tx- somatotrophin receptor agonist-octreotide
Dopamine agonist-act on D2 receptor (shrink tumor prior to sx)
GH receptor agonist