Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHM 701- Alcohol, Seizures, Substance Abuse, Schizophrenia, Depression > SGAs > Flashcards

SGAs Flashcards

1
Q

Aripiprazole indications

A

schizo, BPD, MDD augmentation, Sx associated with autism, Tourette’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Is aripiprazole available as a LAI?

A

Yes!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Is aripiprazole approved for peds patients?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Aripiprazole is associated with what side effect?

A

Impulsivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Other pearls about aripiprazole

A

Little weight gain
May be “activating” and less sedating
May cause insomnia, akathisia, restlessness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Asenapine indications

A

schizo, BPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Asenapine is CI’ed in what disease state?

A

Severe hepatic disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Asenapine puts a patient at high risk for what cardiac event?

A

QTc prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Asenapine comes in what formulation?

A

A topical patch (also SL tablet)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Counseling points for asenapine patch

A

Wear for 24 hours, apply to clean, dry, intact skin on the upper arm, back, abdomen, or hip and rotate with each application

Patches can’t be cut, you can shower but not swim with it, and can’t apply heat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Other pearls about asenapine

A

Little weight gain
Least sedating and anticholinergic
Anaphylaxis could occur after a single dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Brexipiprazole indications

A

schizo, MDD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Brexipiprazole, like aripiprazole, is associated with what side effect?

A

Impulsivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Other pearls about brexipiprazole

A

Dose-related akathisia
Fewer metabolic challenges

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Half-life of brexipiprazole

A

91 HOURS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Cariprazine indications

A

schizo, BPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Half-life of cariprazine

A

2-4 DAYS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Pearls about cariprazine

A

dose-related akathisia
late occurring side effects due to accumulation and metabolites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Clozapine indications

A

schizo, schizoaffective disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Clozapine is the gold standard for what?

A

Refractory illness and suicidality

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Clozapine is on the REMS list because of what?

A

Potential for blood dyscrasias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Blood draw procedures for clozapine REMS monitoring

A

Initiating treatment: blood draw once/week x6 months

After first 6 months: blood draw once q2w x6 months

After 12 months: blood draw qmonth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Clozapine and seizure risk

A

Higher doses increase seizure risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What if higher doses of clozapine are needed?

A

Add on an epileptic drug that can work as a mood stabilizer (Depakote)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What AED should you not use with clozapine?

A

Carbamazepine!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Other clozapine side effects

A

Worst offender of METABOLIC CONDITIONS
QTc prolongation, seizures, myocarditis, constipation, hypersialorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

How to manage constipation while on clozapine

A

Establish a bowel regimen because constipation can lead to surgery, hospitalization, or death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Constipation risk in a patient taking clozapine increases with what meds?

A

Anticholinergic meds and opiates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Smoking and clozapine

A

Smoking (the smoke itself, not the nicotine) induces clozapine metabolism and may need higher doses of clozapine to be effective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

D/C clozapine when the ANC is below what?

A

<1000

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Iloperidone indication

A

schizophrenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Iloperidone is most likely to cause what side effect?

A

Orthostatic hypotension –> slow titration can prevent this!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Iloperidone is not recommended in patients with what disease state?

A

Severe hepatic impairment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Rare but serious side effect of iloperidone

A

QTc prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Other info about iloperidone

A

No prolactin elevation
Less sedating compared to other SGAs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Lurasidone indications

A

schizo, BPD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Drug interaction with lurasidone

A

Don’t use with strong CYP3A4 inhibitors/inducers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Lurasidone and prolactin

A

Lurasidone has no notable prolactin elevation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Lurasidone and weight gain

A

No notable weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Lurasidone and sedation

A

Less sedation compared to other SGAs

41
Q

Lurasidone and orthostasis

A

Less orthostasis compared to other SGAs

42
Q

Is lurasidone approved for peds?

A

Yes

43
Q

Lurasidone dosing

A

Needs hepatic and renal dosing adjustments

44
Q

Lumateperone (Lyrica) indication

A

schizophrenia

45
Q

Lyrica and metabolic changes

A

No significant changes

46
Q

Lyrica and EPS

A

Not associated with an increase in EPS

47
Q

Lyrica monitoring

A

Monitor blood glucose, lipids, and weight despite no significant metabolic changes

MRI for progressive multifocal leukoencephalopathy

48
Q

Other Lyrica side effects

A

Dizziness- caution with overeating and dehydration

49
Q

Lyrica and fertility

A

May impair fertility

50
Q

Lyrica in the third trimester

A

Patient can experience EPS and withdrawal symptoms during the third trimester

51
Q

Lyrica and breastfeeing

A

CI’ed!!

52
Q

Olanzapine indications

A

schizophrenia, BPD, MDD

53
Q

Olanzapine side effects

A

DRESS, sedation, metabolic issues, QTc prolongation, ANC changes

54
Q

Olanzapine is also available as what formulation?

A

LAI

55
Q

Olanzapine LAI info

A

Requires a 3-hour observation period after administration due to post-injection sedation and delirium

56
Q

True or false: olanzapine LAI is in the REMS program

A

True!

57
Q

Is olanzapine approved for peds patients?

A

Yes

58
Q

Paliperidone indications

A

schizophrenia and schizoaffective disorder

59
Q

Paliperidone side effects

A

QTc prolongation, priapism, thrombotic thrombocytopenic purpura

60
Q

Is PO overlap required when switching from olanzapine PO to LAI?

A

NO

61
Q

What formulation is the PO tablet of paliperidone available as?

A

OROS tablet, the shell of the tablet can be found in the stool but that doesn’t mean the drug is working

62
Q

What increases paliperidone bioavailability

A

Food

63
Q

LAI formulations of paliperidone available

A

Sustenna, Trinza, Hafyera

64
Q

Dosing frequency of Sustenna

A

qmonth

65
Q

Trinza dosing frequency

A

q3months

66
Q

Hafyera dosing frequency

A

q6months

67
Q

The transition from Sustenna to Trinza

A

You have to be on Sustenna for at least 4 months before Trinza

68
Q

Is paliperidone approved for peds?

A

Yes

69
Q

Pimavaserin (Nuplazid) indications

A

Hallucinations and delusions associated with Parkinson’s Disease psychosis (this is the only option for this!)

70
Q

What should you not take while on Pimavanserin and why?

A

Dopamine agents, because pimavanserin antagonizes dopamine (Parkinson’s is a deficiency of dopamine)

71
Q

Does pimavanserin carry the same BBW as all other APS?

A

YES!

72
Q

Pimavanserin side effects

A

QTc prolongation, CYP3A4 interactions

73
Q

Don’t use Nuplazid in what disease state?

A

Renal dysfunction <30 ml/min

74
Q

Quetiapine indications

A

schizophrenia, BPD, MDD

75
Q

Quetiapine side effects

A

Sedation, metabolic issues, QTc, cataracts, ACH effects

76
Q

Quetiapine is frequently misused as what?

A

A sleep aid- the risks of an APS are still there though

77
Q

Quetiapine and metabolic effects

A

Not dose-related, but they’re still there

78
Q

Is quetiapine indicated for use in peds?

A

Yes

79
Q

Risperidone indications

A

schizophrenia, BPD, symptoms associated with autism

80
Q

Risperidone side effects

A

PROLACTIN ELEVATION, EPS, Qtc prolongation, priapism, TTP

81
Q

Is risperidone available as a LAI?

A

Yes!

82
Q

LAI dosage forms available for risperidone

A

IM and SQ

83
Q

Risperidone IM LAI form dosing frequency

A

Dosed q2w with PO overlap for 3 weeks

84
Q

Risperidone SQ LAI form dosing frequency

A

Dosed qmonth with no PO overlap needed

85
Q

Ziprasidone indications

A

schizophrenia, BPD

86
Q

Ziprasidone side effect

A

DRESS

87
Q

Ziprasidone CI

A

Patients who are at risk of QTc prolongation

88
Q

Ziprasidone is available as a LAI: true or false

A

False, available as a short-acting agent

89
Q

Paliperidone is a metabolite of…

A

risperidone

90
Q

What drug combinations should you avoid with clozapine and olanzapine?

A

IM benzos (especially lorazepam!)

91
Q

SGAs most likely to cause sedation

A

clozapine and quetiapine

92
Q

SGAs most likely to cause EPS

A

risperidone and paliperidone

93
Q

SGAs most likely to cause ACH effects

A

clozapine

94
Q

SGAs most likely to cause orthostasis

A

clozapine and iloperidone

95
Q

SGAs most likely to cause weight gain

A

clozapine, olanzapine

96
Q

SGAs most likely to cause prolactin elevation

A

risperidone, paliperidone

97
Q

SGAs most likely to cause CV effects

A

clozapine, iloperidone, ziprasidone

98
Q

SGAs available as LAIs

A

aripiprazole, olanzapine, risperidone, paliperidone

99
Q

SGAs available as short-acting agents

A

olanzapine, ziprasidone

PHM 701- Alcohol, Seizures, Substance Abuse, Schizophrenia, Depression (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions