SNRIs Flashcards
Desvenlafaxine indication
MDD
Side effects of desvenlafaxine
HLD, seizures, eosinophilic pneumonia
Desvenlafaxine has interactions with what enzyme?
3A4
Venlafaxine indications
MDD, GAD, panic disorder, social phobias
Venlafaxine side effects
BP changes at higher doses, eosinophilic pneumonia
Counseling point for venlafaxine
Take with food
Venlafaxine as interactions with what enzyme?
2D6
Duloxetine indications
MDD, GAD, fibromyalgia, musculoskeletal and neuropathic pain
Duloxetine side effects
Potential hepatotoxicity, severe skin reactions, small increase in FBG, urinary retention, orthostatic hypotension
What may you see less of with duloxetine?
Less insomnia potential
What should you avoid when taking duloxetine?
ALCOHOL
Avoid duloxetine in what patients?
ESRD and liver dysfunction
Levomilnacipran indication
MDD
Levomilnacipran side effects
Urinary retention, increased heart rate
SNRI dosing and elderly patients
No dosing adjustments needed!
Side effects of all SNRIs
HTN, tachycardia and palpitations, orthostatic hypotension, N/V, constipation, urinary hesitation, risk of mania/hypomania
Are SNRIs more energy-boosting or sedating?
Energy-boosting
Watch out for this in SNRIs
Abnormal bleeding, increased risk of mania activation, elevated blood pressure, hyponatremia, serotonin syndrome and discontinuation syndrome, angle-closure glaucoma
SNRIs that inhibit serotonin and NE uptake (but also weak for DA)
Venlafaxine, desvenlafaxine
SNRIs that inhibit serotonin and NE uptake
duloxetine, levomilnacipran, minalcipran
Agents to avoid while taking a SNRI
Other serotonergic agents, MAOIs, linezolid, methylene blue
