Serotonin Modulators

Question 1

Serotonin modulators are indicated in what?

Answer 1

MDD only

Question 2

Serotonin modulators

Answer 2

Nefazodone, trazodone, vilazodone, Trintellix

Question 3

First line serotonin modulator

Answer 3

Trintellix

Question 4

Nefazodone ADEs

Answer 4

Priapism, orthostatic hypotension, nausea, constipation, dry mouth, liver failure, HA, dizziness, somnolence, blurred vision, sexual dysfunction

Question 5

Use nefazodone with caution in what patients?

Answer 5

Seizure patients

Question 6

Nefazodone monitoring

Answer 6

Liver function and CYP3A4 inhibitors

Question 7

Trazodone side effects

Answer 7

Same as nefazodone (minus BBW), also sedation

Question 8

Use trazodone with caution in what disease states?

Answer 8

CVD, MI, QTc prolongation

Question 9

Trazodone monitoring

Answer 9

Liver function and CYP3A4 inhibitors

Question 10

Vilazodone side effects

Answer 10

diarrhea, nausea, vomiting, insomnia, dreams, bleeding, serotonin syndrome, angle closure glaucoma, hyponatremia, seizures

Question 11

Vilazodone has less…

Answer 11

…sexual dysfunction

It also has a rapid onset of action and improved efficacy, improved tolerability

Question 12

Trintellix side effects

Answer 12

diarrhea, N/V, dizziness, sexual dysfunction, discontinuation syndrome

Question 13

Trintellix has interactions with what enzyme?

Answer 13

2D6

Question 14

Trintellix counseling points

Answer 14

Take with food to reduce GI side effects and improve efficacy