MAOIs Flashcards
MAOIs in the treatment algorithm
Should be used as a last-line option!
Why are MAOIs a last-line option?
Due to dietary restrictions, drug interactions, and the side effects
MAOIs are only indicated for…
…MDD
MAOIs
Phenelzine, selegiline, tranylcypromine
If you’re starting a MAOI, what should you do with other interacting meds?
Wait 4-5 half-lives of the interacting medication before starting a MAOI
Which meds do you have to wait >2 weeks before starting an MAOI and why?
Fluoxetine and Trintellix because they have the longest half-lives
How long do you have to wait to start an MAOI if you were taking fluoxetine?
5 weeks (Five, Fluoxetine)
How long do you have to wait to start an MAOI if you were taking Trintellix?
3 weeks (Three, Trintellix)
Dietary restriction while on an MAOI
No tyramine-containing foods, so no wine, cheeses, aged meats, pickled products, smoked products, yeast extracts
What happens if you eat tyramine-containing foods while on an MAOI?
Hypertensive crisis
Other MAOI side effects
Postural hypotension, diarrhea, anticholinergic drying effects, sexual dysfunction
MAOI drug interactions that would cause hypertensive crisis
amphetamines, decongestants, methylphenidate
MAOI drug interactions that would cause serotonin syndrome
DMX
Other MAOI drug interactions
asthma inhalants, Tegetrol, buspirone, -triptans
