Set 6 (Pulmonary) Flashcards

1
Q

Pleomorphic
Gram- coccobacillus

Requires X and V factor (hematin, NAD+)

A

H. influenzae

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2
Q

Penetrating injury SUPERIOR to cricoid cartilage

A

Ansa cervicalis
(C1, C2, C3)
(Sternohyoid, Sternothyroid, Omohyoid)

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3
Q

Mucs-secreting cells of respiratory tree are present to?

A

The level of the smallest bronchi

NO mucous secreting cells w/i bronchioles

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4
Q

Nystatin: indication

A

TOPICAL: oral candidiasis (“swish and swallow”)

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5
Q

Polyene antifungals

A

Amphotericin B
Nystatin
(binds ergosterol in fungal cell membrane)

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6
Q

Which has greater effect on brain perfusion? CO2 or O2

A

Carbon dioxide!!!

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7
Q

Complement-mediated cytotoxcity is a function of what Ig?

A

IgM (mostly)
IgG
(NOT IgE)

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8
Q

Direct-acting alkylating agents a/w?

A

Acute leukemias.

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9
Q

Beta-napthylamine

aniline dynes, rubber industry

A

Bladder carcinoma.

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10
Q

Lactic acidosis associated with what drug?

A

Metformin

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11
Q

L-cysteine enrichment

Charcoal-yeast extract agar

A

Legionella

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12
Q

Griseofulvin indication

A

Dermatophyte (Microsporum, Epidermophyton, Trichophyton)

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13
Q

Anti-fungal that accumulates in keratin-containing tissue

A

Griseofulvin

interacts with fungal MT

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14
Q

Always pathologic when heard in young person: S3 or S4.

A

S4: always.
S3: not always

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15
Q

Antibiotic of choice for treating lung abscesses (anaerobe + aerobic bacterias)

A

Clindamycin (covers both anaerobic AND aerobic)

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16
Q

Metronidazole: coverage

A

Excellent anaerobes

NO aerobes

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17
Q

Ciprofloxacin: coverage of anaerobes.

18
Q

Inferior thyroid artery

posterior to carotid a., jugular v.

A

From thyrocervical trunk (from subclavian a.)

19
Q

Hyaluronidase

A

C. diff
Staphlococcus
GAS

20
Q

Amantadine

A

Impaires uncoating of Influenza A AFTER host cell endocytosis

21
Q

Mast cell activation: maker

A

Widespread mast cell degranulation

22
Q

Ganciclovir

A

Anti-herpesvirus guanine nucleoside analogue

GREATER activity against CMV DNA polymerase

23
Q

Lamivudine

A

Anti-RETROviral nucleoside reverse transcriptase inhibitor

HIV

24
Q

Oseltamivir

A

Sialic acid analogue inhibitor of:

Influenza A and B viral neuraminidase

25
Montelukast
LTD4 receptor ANTAgonist | chronic asthma prophylaxis
26
Viral bronchiolitis in infants
RSV! | tx: Ribavirin
27
Amphotericin B: MOA
Binds to ergosterol of fungal cell membrane
28
Severity of MS:
A2-OS interval | Shorter=more severe
29
Hib vaccine
Bacterial capsular polysaccharide conjugated w/ diptheria toxoid
30
Amphotericin A/E
NEPHROtoxicity HYPOkalemia HYPOmagnesemia
31
Infective endocarditis causes stenosis?
NO, REGURG | RF can cause MS, MR & AR
32
Omalizumab
Inhibit IgE binding to mast cell | Binds to mast cell w/o triggering degranulation
33
Killed or viral component vaccines predominantly generate _______response.
Humoral
34
Acute necrotizing pancreatitis is a major risk factor for this respiratory dz?
ARDS
35
Ribavirin
(nucleoside analog that inhibit synthesis of guanine nucleotide) RSV HepC
36
Cold agglutinin formation
Mycoplasma pneumoniae. EBV. Hematologic malignancy.
37
Zileuton
Selective inhibitor of lipoxygenase pathway | Asthma
38
Secondary bacteria pneumonia:
S. pneumo H. flu S. aureus
39
Isonizid: MOA
Inhibit mycolic acid synthesis | activated by mycobacterial enzyme catalase-peroxidase
40
Rifampin MOA
Block action of bacterial DNA-dep-RNA polymerase
41
30S
Tetracycline Doxycycline Aminoglycoside
42
50S
Clindamycin Linzezoid Macrolides Chloramphenicol