Set 16 (Hematology) Flashcards by Ruby Chang

Ristocetin test is for?

vWF!!!

+ test is due to poor platelet aggregation

How well did you know this?

Not at all

Perfectly

von Willebrand dz: inheritance

Autosomal dominant (variable, incomplete penetrance)

How well did you know this?

Not at all

Perfectly

Smudge cell

CLL

How well did you know this?

Not at all

Perfectly

Lifelong hx of gingival bleeding, epistaxis, mucosal bleeding, menorrhagia

vWF disease

How well did you know this?

Not at all

Perfectly

B6 deficiency: what type of anemia?

HYPO-MICRO sideroblastic anemia

How well did you know this?

Not at all

Perfectly

Bcl-2 mutation

CLL

Follicular lymphoma

How well did you know this?

Not at all

Perfectly

Hematology

JAK2-STAT

Polythemia vera
Essential thrombocytosis
Primary myelofibrosis

How well did you know this?

Not at all

Perfectly

Direct factor 10a inhibitors

Idraparinux
Rivaroxaban
Apixaban
Ultra LMWH

How well did you know this?

Not at all

Perfectly

Enveloped

ssDNA

Parvovirida

How well did you know this?

Not at all

Perfectly

Neutropenia
Fever
Mouth ulcers
What anti-platelet?

Ticlodipine

How well did you know this?

Not at all

Perfectly

Amiodarone and warfarin

Amiodarone INHIBIT CYP450 (warfarin toxicity)

How well did you know this?

Not at all

Perfectly

Direct thrombin inhibitor

Argatroban

Dabigatran

How well did you know this?

Not at all

Perfectly

Rifampin
Phenobarbital
Phenytoin

ENHANCERS of CYP450

How well did you know this?

Not at all

Perfectly

VitD RESISTANT rickets

X-linked DOMINANT

How well did you know this?

Not at all

Perfectly

Cimetidine
Amiodarone
TMP-SMX

INHIBITORS of CYP450

How well did you know this?

Not at all

Perfectly

Blocker of GPIIb/IIIA receptor

Abciximab

How well did you know this?

Not at all

Perfectly

Cimetidine and CYP450

Inhibit CYP450

How well did you know this?

Not at all

Perfectly

TMP-SMX and CYP450

Inhibit

GP IIb/IIIa deficiency

Glanzmann thrombasthenia

No platelet clumping

Oculocutaneous Albinism
Defective phagosome-lysosome fusion
Peripheral neuropathy

Chediak-Higashi

Eczema, Thrombocytopenia, Combined B&T deficiency

Wiskott-Aldrich

Charcot-Bouchard pseudoaneurysm

Small arterioles that penetrate basal ganglia and thalami
Intraparenchymal hemorrhage
Hypertension

Physostigmine vs. Neostigmine and edrophonium

Physostigmine = TERTIARY amine

Can penetrate CNS!!!!

Chlorpromazine
Haloperidol
Ziprasidone
Olanapine
Clozapine
Thioridazine
A/E

C: corneal deposits
H: extrapyramidal sx
Z: prolonged QT
O: weight gain
C: agranulocytosis and seizures
T: retinal deposits that resemble retinitis pigmentosa

Friedrich ataxia

AR Difficulty walking a/w: Hypertrophic CM, Kyphoscloliosis, Foot abnormalities, DM

Huntington disease: NTM

Loss of GABA-containing neurons in striatum due to increased # of trinucleotide repeats in HD gene (chromosome 4)

3rd cranial nerve: location of exit

Btwn: Posterior cerebral Superior cerebellar

Homocysteinuria m/c mutation in?

Cystathione synthetase | require B6

Difficulty releasing door nob (sustained muscle contraction) Weakness and atrophy Cataracts, Frontal balding, Gonadal atrophy

Myotonic dystrophy | AD

Live attenuated vaccines

Francisella tularensis | Salmonella typhi

Treatment of choice for alcohol withdrawal

Long-acting benzodiazepams (Chlordiazepoxide, diazepam) If liver dysfunction: use short acting: lorazepam, oxazepam

Serotonin is made from?

Tryptophan | via tryptophan hydroxylase

Arginase

Arginine --> Urea and Ornithine

Elevated 14-3-3 protein in CSF

Creutzfeldt-Jakob dz

Hypocretin-1 and Hypocretin 2 | orexin-A, orexin-B

Decreased in narcolepsy | Made by lateral hypothalamus (promote wakenfulness, inhibit REM sleep phenomena)

Fever, muscle rigidity after general anesthesia (inhalation anesthetic, muscle relaxant succinylcholine) Tachycardia, HTN, HYPERkalemia, MYOglobinemia

Malignant hyperthermia

1st line for treating generalized anxiety disorder

Buspirone | selective agonist of 5HT-1A receptor

Tolerance to opioid does not occur in these A/E

Constipation | Miosis

Gerstmann's syndrome

Dominant hemisphere! Dysgraphia, Dyslexia, Dyscalculia Right/left confusion

NON-dominant hemisphere inferior parietal lobe involvement

Apraxia | Contralateral hemineglect

Carboxylation rxn | Decarboxylation rxn

Carboxylation: Biotin | Decarboxylation/Transaminase: B6

Transketolase rxns | Dehydrogenase rxns

Thiamine

Lewy bodies

Parkinson's disease