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UWorld > Set 16 (Hematology) > Flashcards

Set 16 (Hematology) Flashcards

1
Q

Ristocetin test is for?

A

vWF!!!

+ test is due to poor platelet aggregation

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2
Q

von Willebrand dz: inheritance

A

Autosomal dominant (variable, incomplete penetrance)

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3
Q

Smudge cell

A

CLL

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4
Q

Lifelong hx of gingival bleeding, epistaxis, mucosal bleeding, menorrhagia

A

vWF disease

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5
Q

B6 deficiency: what type of anemia?

A

HYPO-MICRO sideroblastic anemia

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6
Q

Bcl-2 mutation

A

CLL

Follicular lymphoma

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7
Q

Hematology

JAK2-STAT

A

Polythemia vera
Essential thrombocytosis
Primary myelofibrosis

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8
Q

Direct factor 10a inhibitors

A

Idraparinux
Rivaroxaban
Apixaban
Ultra LMWH

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9
Q

Enveloped

ssDNA

A

Parvovirida

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10
Q

Neutropenia
Fever
Mouth ulcers
What anti-platelet?

A

Ticlodipine

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11
Q

Amiodarone and warfarin

A

Amiodarone INHIBIT CYP450 (warfarin toxicity)

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12
Q

Direct thrombin inhibitor

A

Argatroban

Dabigatran

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13
Q

Rifampin
Phenobarbital
Phenytoin

A

ENHANCERS of CYP450

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14
Q

VitD RESISTANT rickets

A

X-linked DOMINANT

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15
Q

Cimetidine
Amiodarone
TMP-SMX

A

INHIBITORS of CYP450

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16
Q

Blocker of GPIIb/IIIA receptor

A

Abciximab

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17
Q

Cimetidine and CYP450

A

Inhibit CYP450

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18
Q

TMP-SMX and CYP450

A

Inhibit

19
Q

GP IIb/IIIa deficiency

A

Glanzmann thrombasthenia

No platelet clumping

20
Q

Oculocutaneous Albinism
Defective phagosome-lysosome fusion
Peripheral neuropathy

A

Chediak-Higashi

21
Q

Eczema, Thrombocytopenia, Combined B&T deficiency

A

Wiskott-Aldrich

22
Q

Charcot-Bouchard pseudoaneurysm

A

Small arterioles that penetrate basal ganglia and thalami
Intraparenchymal hemorrhage
Hypertension

23
Q

Physostigmine vs. Neostigmine and edrophonium

A

Physostigmine = TERTIARY amine

Can penetrate CNS!!!!

24
Q 
Chlorpromazine
Haloperidol
Ziprasidone
Olanapine
Clozapine
Thioridazine
A/E
A 
C: corneal deposits
H: extrapyramidal sx
Z: prolonged QT
O: weight gain
C: agranulocytosis and seizures
T: retinal deposits that resemble retinitis pigmentosa
25
Q

Friedrich ataxia

A

AR
Difficulty walking
a/w: Hypertrophic CM, Kyphoscloliosis, Foot abnormalities, DM

26
Q

Huntington disease: NTM

A

Loss of GABA-containing neurons in striatum due to increased # of trinucleotide repeats in HD gene (chromosome 4)

27
Q

3rd cranial nerve: location of exit

A

Btwn:
Posterior cerebral
Superior cerebellar

28
Q

Homocysteinuria m/c mutation in?

A

Cystathione synthetase

require B6

29
Q

Difficulty releasing door nob (sustained muscle contraction)
Weakness and atrophy
Cataracts, Frontal balding, Gonadal atrophy

A

Myotonic dystrophy

AD

30
Q

Live attenuated vaccines

A

Francisella tularensis

Salmonella typhi

31
Q

Treatment of choice for alcohol withdrawal

A

Long-acting benzodiazepams
(Chlordiazepoxide, diazepam)

If liver dysfunction: use short acting: lorazepam, oxazepam

32
Q

Serotonin is made from?

A

Tryptophan

via tryptophan hydroxylase

33
Q

Arginase

A

Arginine –> Urea and Ornithine

34
Q

Elevated 14-3-3 protein in CSF

A

Creutzfeldt-Jakob dz

35
Q

Hypocretin-1 and Hypocretin 2

orexin-A, orexin-B

A

Decreased in narcolepsy

Made by lateral hypothalamus (promote wakenfulness, inhibit REM sleep phenomena)

36
Q

Fever, muscle rigidity after general anesthesia (inhalation anesthetic, muscle relaxant succinylcholine)

Tachycardia, HTN, HYPERkalemia, MYOglobinemia

A

Malignant hyperthermia

37
Q

1st line for treating generalized anxiety disorder

A

Buspirone

selective agonist of 5HT-1A receptor

38
Q

Tolerance to opioid does not occur in these A/E

A

Constipation

Miosis

39
Q

Gerstmann’s syndrome

A

Dominant hemisphere!
Dysgraphia, Dyslexia, Dyscalculia
Right/left confusion

40
Q

NON-dominant hemisphere inferior parietal lobe involvement

A

Apraxia

Contralateral hemineglect

41
Q

Carboxylation rxn

Decarboxylation rxn

A

Carboxylation: Biotin

Decarboxylation/Transaminase: B6

42
Q

Transketolase rxns

Dehydrogenase rxns

A

Thiamine

43
Q

Lewy bodies

A

Parkinson’s disease

UWorld (17 decks)

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