sepsis Flashcards

1
Q

what is sepsis

A

dysregulated host response to infection leading to life threatening end organ dysfunction

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2
Q

what is septic shock

A

sepsis with evidence of cardiovascular dysfunction
hypotension is a late sign

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3
Q

how to recognise sepsis

A

should be considered in a patient with suspected or proven infection and/or fever/hypothermia
plus
any sign of impaired tissue perfusion

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4
Q

signs of impaired tisssue perfusion

A

tachycardia
bradycardia
cold shock: raised CRT, cool peripheries, cool or mottled skin, reduced peripheral pulses, narrow pulse pressure
warm shock: reduced CRT, boudning pulses, wide pulse pressure
altered level of consciousness
new onset end organ dysfunction
evolving petechial or purpuric rash
unexplained pain

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5
Q

cold shock

A

raised CRT, cool peripheries, cool or mottled skin, reduced peripheral pulses, narrow pulse pressure

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6
Q

warm shock

A

reduced CRT, boudning pulses, wide pulse pressure

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7
Q

inital management of sepsis

A

call for help
apply oxygen
establish vascular access
take blood (should not delay Abs)
commence Abs
commence fluid resus
correct hypoglycaemia if present

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8
Q

how to call for help

A

in ED: call consultant, move patient to resus room, consider PCC review
on ward: follow sepsis recognition escalation pathway on the observation and response chart

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9
Q

what should you send the bloods for

A

blood culture, lactate (venous blood gas), FBC, ureaa, electrolytes and creatinine, LFTs, coagulation profile, and CRP

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10
Q

ongoing resus

A

continue fluid resus with repeat boluses 10-20ml/kg of sodium chloride 0.9% as needed

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11
Q

if circulatory failure persists following 40ml/kg saline

A

PCC review
consider peripheral ionotropes
consider further fluid bolus
prepare for intubation
arrange transfer to PCC
consider hydrocortisone for fluid refractory, catecholamine resistant shock

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12
Q

high risk groups

A

infants less than 3 months of age
immunosuppression due to chemo, long term steroids, other immunosuppresssants, asplenia and other chronic medical conditions
unimmunissed/incomplete immunisation
children with central venous access devices, indwelling medical devices
recent surgery, burn or wound
rural, remote or socioeconomic issues
re-presentation

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13
Q

vascular accesss

A

if IV access cannot be obtained, opt for intraosseous access
it may be appropriate to opt for intraosseous acces initially in critically unwell patient or for whom access is clearly going to be difficult

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14
Q

blood tests

A

hould be taken at the time of IV access, wth priority given to venous blood gas and blood culture collection
antibiotic administration and fluid resus mut not be delayed by repeated attempts to collect blood samples

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15
Q

blood lactate

A

a normal blood lactate level does not exclude sepsis
there is an association between elevated blood lactate and adverse outcomes in paediatric septic shock

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16
Q

hypoglycaemia

A

all children should have blood glucose checked
correct hypoglycaemia with 2ml/kg of glucoe 10%
repeat BGL after treatment

17
Q

antibiotics

A

infants < 4 weeks: cefotaxime, immediately then amoxicillan, consider adding gentamycin or aciclovir
infant/child > 4 weeks old: ceftriaxone immidiately then gentamycin

18
Q

when should you add vanc

A

in an infant/child > 4 weeks who
- is too unwell for LP
- gram positve coccii seen on CSF
- recent treatment with penicilln, cephalosporin or carbepenam

different for healthcare associated antibiotics

19
Q

adrenaline infusion

A

add 6mg to a 1L bag of saline 0.9%

20
Q

intubation

A

in sepsis this is a high risk procedure
if GCS<8, imminent respiratory or cardiac failure, or perisstant shock or instability

21
Q
A