Sensory Physiology Flashcards
Specific sensations, specific receptors
Differential Sensitivity
Specific sensations, specific pathways
Labeled line principle
Change in a way a receptor responds to sequential or prolonged stimulation
Adaptation
For continuous stimulus strength (detects steady stimulus)
Slowly-adapting receptor (Tonic Receptors)
Slowly-adapting receptor (Tonic Receptors)
Muscle spindle, Golgi tendon, slow pain receptor, baroreceptor, chemoreceptors
For detecting change in stimulus strength (detects onset and offset of stimulus)
Rapidly-adapting Receptors (Phasic Receptors)
Rapidly-adapting Receptors (Phasic Receptors)
Pacing an Corpuscle
Receptor potential in a Pacinian Corpuscle
If depolarizing, brings the membrane potential closer to threshold
Smaller receptive field with well-defined border
Type 1
Wider receptive field with poorly-defined borders
Type 2
2 point discrimination receptor?
Type 1 receptor field
Stationary
Merkel’s
Moving
Me issuers
Touch & pressure in the skin
Free Nerve Endings
Movement of objects & low frequency vibration
In non-hairy skin esp. Fingertips and lips
Meissner’s Corpuscle (FA1)
Gives steady-state signals for continuous touch
Localizing touch sensation and to determine texture
Combine to form Dome Receptors
Expanded tip tactile receptor
Merkel’s Disc (SA1)
Movement of object on the skin
Hair-end organ
Heavy & prolonged touch (pressure) and to signal degree of joint rotation
In deep skin, internal tissues & joint capsules, multi-branched, encapsulated, slowly-adapting
Ruffini’s end organs (SA2)
Detects high-frequency vibration
Onion-like structure in skin & deep fascia
Pacinian Corpuscles (FA2)
Transducers stimulus to electrical signal
Sensory Receptors
Cell Body: Dorsal Root or Cranial Nerve Ganglia
First-Order Neurons
Cell Body: Spinal Cord or Brainstem
Second-Order Neurons
Cell Body:Thalamus
Third ORder Neurons
Cell body: Sensory Cortex
Fourth-Order Neurons
Uses large myelinated fibers (group II), conduction velocity 30-110 m/s
Dorsal Column-Medial Lemniscus Pathway
cRosses near the medulla
Dorsal Column-Medial Lemniscus Pathway
Uses smaller myelinated fibers (group III, IV) 8-40 m/s
Antero-Lateral System (Spinothalamic Tract)
Relay station for sensation
Thalamus
VPL nuclei
Dorsal Column-Medial Lemniscus Pathway
VPM
TrigeminoThalamic pathway
VPI nuclei
Anterolateral system
Neurotransmitters for pain
Glutamate & substance P
Fast pain
Aka first/sharp/pricking/acute/electric pain
Type A delta fibers
Fast pain
Neurotransmitter for Fast Pain
Glutamate
Slow Pain
Aka second/aching/throbbing/nauseous/chronic pain
Type C fiber
Slow pain
Neurotransmitter for Slow Pain
Substance P
Due to sharing of 2nd order neurons in the spinal cord of visceral pain fibers and skin pain fibers
Referred pain
Warmth Receptors
Free nerve endings, Type C fibers
Cold Receptors
Type A delta fibers, some Type C
Pain Receptors
<15 deg C or > 43 deg C
Distant objects
Lens should be flat
Tensed suspensions ligament
Relaxed ciliary muscle
Nearby Objects
Lens should be spherical
Relaxed suspensions ligament
Contracted ciliary muscles
Gelatinous with little flow
Behind the lens
Vitreous Humor
Produced by Ciliary body
Exits into Canal of Schlemm
Free flowing
Main determinant of IOP
Aqueous Humor