Gastrointestinal Physiology Flashcards
Use to locate the appendix
TAEnia Colin
ANTRUM
G cells
Parietal cells (IF, HCL)
Fundus
Vitamin C & iron are absorbed
Duodenum
All nutrients are absorbed
Jejunum
Vitamin B12, IF, ADEK, Bile salt, Bile acids are absorbed
Ileum
Folate
Jejunum
Vagus nerve found
Transverse colon
Absorption of water
Proximal colon
Storage of feces
Rectum
Distal Colon
Basic GI Layers
Mucosa
Submucosal
Muscularis
Serosa
Smooth muscle cells controlling the epithelium
Muscularis Mucosa
Collagen, elastin, glands and blood vessels
Submucosa
Decreases diameter of the lumen
Inner Circular Muscle Layer
Shortens segment of the GIT
Outer Longitudinal Muscle Layer
Aka adventitia or mesothelium
Serosa
between inner circular & outer longitudinal muscle layers For motility (inner circular & outer longitudinal muscle layers)
Myenteric Plexus / Auerbach Plexus
Which layer is NOT seen in the esophagus?
Serosa
Strongest layer of the esophagus?
Submucosa
3 muscle layers are found in the stomach instead of two. What are these muscle layers?
Inner Oblique
Middle Circular
Outer Longitudinal
The Myenteric Plexus is mainly excitatory EXCEPT for which regions?
Pyloric Sphincter & Ileocecal Valve
Esophageal to upper large intestines
vagus nerve
Lower large intestines to anus
Pelvic nerves
Secretion & absorption
Meisner plexus/ Submucosal Plexus
Motility
Auerbach plexus/ Myenteric Plexus
For retropulsion of food
Inner oblique
G cells, stomach, Antrim
Gastrin
Stimulus: small peptides, stomach Distention, vagus nerve via GRP; inhibited by H & somatostatin
Gastrin
Increases gastric H secretion
Stimulates growth of gastric mucosa
Gastrin
S cells
Duodenum
Secretin
Stimulus: H in duodenum
Fatty acids in duodenum
Secretin
Increases Pancreatic HCO3 secretions
Increases Biliary HCO3 secretion
Decreases effect of gastric on gastric mucosa
Secretin
I cells
Duodenum & Jejunum
CCK
Cholecystokinin
Monoglycerides, FA, small peptides and AA
CCK
Cholecystokinin
Stimulates GB contraction, sphincter of Oddi Relaxation
Increases Pancreatic enzyme & HCO3 secretion
Increases growth of exocrine pancreas and gallbladder
Inhibits gastric emptying
CCK
Cholecystokinin
K cells
Duodenum
Glucose - dependent Insulinotropic Peptide
Stimulus: Oral glucose, fat, AA
Glucose - dependent Insulinotropic Peptide
Increases Insulin secretion
Inhibits Gastric Emptying (only above normal physiologic levels)
Glucose - dependent Insulinotropic Peptide (GDIP)
M cells
Duodenum
Jejunum
Motilin
stimulus: Fasting
Motilin
Stimulates
Motilin
Most potent stimuli for gastric secretion
phenylalanine
Tryptophan
Methionine
Neurocrine from vagus nerve to G cells
GRP/Bombesin
GI hormone classifies as an INCRETIN
GIP
GLP 1
GI hormone responsible for the interdigestive myoelectric complex
Motilin
Secreted by pancreas in response to CHO, CHON, lipids
Pancreatic Polypeptide
Inhibits pancreatic HCO3 and enzymes
Pancreatic Polypeptide
Secreted by intestinal cells in response to hypoglycemia
Enteroglucagon
Stimulates glycogenolysis and gluconeogenesis
Enteroglucagon
Secreted by L-cells of small intestines
Glucagon-Like Peptide 1 (GLP-1)
Stimulates insulin secretion
Glucagon-Like Peptide 1 (GLP-1)
Secreted by cells throughout the GIT in response to H
Somatostatin
Inhibits release of ALL GI hormones
Somatostatin
Inhibits gastric H secretion
Somatostatin
Secreted by mast cells of gastric mucosa
Histamine
Increases H secretion; potentials gastric and Ach action
Histamine
Action of Ach
Contraction of smooth muscle in wall Relaxation of sphincter a Inc salivary secretion Inc gastric secretion Inc pancreatic secretion
Source of Ach
Cholinergic neurons
Action of NE
Relaxation of smooth much in wall
Contraction of sphincters
Inc salivary secretion
Source of NE
Adrenergic Neurons
Actions of VIP Vasoactive intestinal Peptide
Relaxation of smooth muscle
Inc intestinal secretion
Inc pancreatic secretion
Source of VIP
Neurons of mucosa and smooth muscle
Action of Gastrin-Releasing (GRP) or Bombesin
Inc gastric secretion
Source of GRP or Bombesin
Neurons of gastric mucosa
Actions of Enkephalins (Opiates)
Contraction of smooth muscle
Dec intestinal secretion
Source of Enkephalins
Neurons of mucosa and smooth muscle
Actions of neuropeptide Y
Relaxation of smooth muscle
Dec intestinal secretion
Source of Neuropeptide Y
Neurons of mucosa and smooth muscle
Action of substance P
Contraction of smooth muscle
Inc salivary secretion
Source of Substance P
Consecrated with Ach
Inhibits appetite
Found at the Ventromedial Hypothalamus
Satiety Center
Stimulates appetite
Found at the Lateral Hypothalamic Area
Appetite/Hunger Center
Sends signals to Satiety & Hunger Centers
Arcuate Nucleus
Releases POMC to decrease appetite
Anorexigenic Neurons
Releases Neuropeptide Y to increase appetite
Orexigenic Neurons
Stimulates Anorexigenic neurons, inhibits orexigenic neurons
leptin (fats cells), Insulin, GLP-1
Inhibits Anorexigenic neurons
Gherkin (gastric cells)
Inhibits gherkin
Peptide Y
Constant level of contraction or tone without regular periods of relaxation
Tonic contractions
Due to subthreshold slow waves
Tonic contractions
Orad (upper) region of the stomach and in the lower esophageal, Ileocecal and internal anal sphincter so
Tonic contractions
Periodic contractions followed by relaxation
Phasic Contractions
for mixing and propulsion
Due to spike potentials
Phasic Contractions
Seen in the esophagus, gastric Antrum, small intestines
Phasic Contractions
Not true action potential
Slow waves
Due to GI pacemaker Intertitial cell of cajal
Slow waves
Slowest frequency
Stomach
Fastest frequency
Small intestines