Reproductive Physiology Flashcards
defined by Sex Chromosome
Genetic Sex
Defined by Presence of Ovaries /Testes
Gonadal Sex
Defined by characteristics of internal genital tract and external genitalia?
Phenotypic Sex
internal Genital tract in Males
Prostate, Seminal Vesicles, Vas Deferens, Epididymis
Internal Genital Tract in Females
Fallopian Tube, Uterus, Upper 1/3 Vagina
External Genital tract in Males
Scrotum, Penis
External Genital tract in Females
Clitoris, Labia Minora & Majora, Lower 2/3 Vagina
secreted by Sertoli Cells to cause atrophy of Mullerian ducts (FEMALE)
Antimullerian Hormone
secreted by Leydig Cells for Growth of Wolffian duct (MALE)
testosterone
which substance is suspected to initiate puberty?
Melatonin
what conditions may inhibit the onset of puberty?
Stress, Malnutrition
what is the first event in puberty?
Males: Testicular Enlargement
Females: Breast Enlargement
which hormone causes adrenarche (pubic hair, axillary hair development) in females?
Adrenal Androgens
XY
male
XX
female
Testosterone functions
- differentiation of epididymis, vas deferens & seminal vesicles
- descent of testes
- increased bone and muscle mass
- increases BMR
- Pubertal growth spurt
- epiphyseal closure
- growth of penis & seminal vesicles
- deepening of voice
- spermatogenesis
- negative feedback on anterior pituitary
- libido
Dihydrotestosterone functions
- differentiation of penis, scrotum, and prostate
- male hair pattern
- male pattern baldness
- sebaceous gland activity
- growth of prostate
for sperm production
Seminiferous Tubules
for sperm maturation, motility
Epidydimis
for sperm storage
vas deferens
for sperm nutrition, etc. (FRUCTOSE, PROSTAGLANDIN)
Seminal Vesicles
for Semen Alkalinity (Spermine)
Prostate Gland
supplies Mucus
Urethral gland Bulbuurethral Glands
Path of SEMEN
SEVEN UP
S-eminiferous tubules E-pididymis V-as deferens E-jaculatory duct N-none U-rethra P-enis
testes temperature
1-2 degree celcius cooler
responsible for testes temperature
countercurrent exchange of the testicular vessels
duration of spermatogenesis
64 days
sperm production per day
128 million
activation of sperm in the female genital tract for 4-6 hours
capacitation
what is the Enzyme that convert androstenedione to testosterone?
17B-hydroxysteroid dehydrogenase
what is the enzyme that convert testosterone to dihydrotestosterone?
5a reductase
what is the 5a-reductase inhibitor used for male pattern baldness and BPH?
Finasteride
granulosa cells
Theca Cells
Estrogen
Luteal Cells
Progesterone
stages of Male Sexual Act
erection
lubrication
orgasm
resolution
contracts vas deferens, seminal vesicles, prostate
Emission
contracts bulbocsvernous, ischcavernous
ejaculation
cell which determine Sex of a Baby
sperm cell
part of the sperm cell that contains hyaluronidase, proteolytic enzymes
acrosome
acrosome comes from which organelle?
Golgi Apparatus
definition of Low Sperm Count
<20 million sperms/,;
sequelae of Cryptorchidism
infertility
testicular CA
loss of body hair, musculature, thick bones, decreased libido
Castration after puberty
vestigial remnant of 3rd eye; secretes melatonin which is involve in reproduction and sex drive
Pineal Gland
Primordial Follicle
Granulosa Cell
Primary Follicle
Theca Interna
Theca Externa
provides nourishment to ovum
secretes inhibiting factor to keep ovum in prophase
Granulosa Cells
secrete estrogen & progesterone
Theca Interna
becomes capsule of the follice
theca Externa
it forms Corona Radiata and secrete estrogen-rich fluid(forms ANtrum)
Granulosa Cells
secrete adrenal cortex & theca cells
Estrone
secreted by ovaries
Estradiol
secreted by placenta
Estriol
enzyme that catalyzes conversion of Androstenodione -> Estrone & Testosterone -> Estradiol
Aromatase
seen during reproductive years
Estradiol
seen during pregnancy
Estriol
seen post-menopause
estrone
secreted by the corpus luteum, placenta, adrenal cortex, testes
progesterone
Estrogen Functions
- maturation of uterus, fallopian tubes, cervix, vagina
- breast development
- development of granulosa cells
- up-regulation of estrogen, progesterone, and LH receptors
- negative and positive feedback effects on FSH and LH secretion
- maintenaceof pregnancy
- lowering of uterine threshold to contractile stimuli
- stimulates prolactin secretion
- blocks action of prolactin on breast
- slightly increases BMR but causes fat deposition
- creates soft skin
- inhibits osteoclasts
Progesterone Functions
- maintenace of secretory activity of uterus during luteal phase
- breast development
- negative feedback effects on FSH and LH secretion
- maintence of pregnancy
- raising uterine threshold to contractile stimuli during pregnancy
will cause menses
corpus albicans
trigger for menstruation
Progesterone
estrogen predominates
Follicular/Proliferative Phase
progesterone predominates
Luteal/Secretory Phase
Endometrial Cycle
Proliferative
Secretory
Menses
stromal & epithelial cells proliferate
cervical mucus: thin, stringy, (+) ferning
Proliferative Phase
increased tortuosity of glands and blood vessels
increased lipid & glycogen in the stromal cells
Cervical Mucus: thick, non-elastic, (-) ferning
Secretory Phase
due to cessation of Progesterone
(+) necrosis of endometrium, bleeding and desquamation
Menses
Menstruation
Estrogen: dec
Progesterone: dec
FSH: dec
LH: dec
Follicular Phase
Estrogen: inc
Progesterone: dec
FSH: inc
LH: dec
Ovulation
Estrogen: inc
Progesterone: dec
FSH: inc
LH: inc
Luteal phase
Estrogen: dec
Progesterone: inc
FSH: dec
LH: dec
produced by ovarian granulosa cell and inhibits FSH secretion from anterior pituitary
Inhibin
produced by ovarian granulosa cell and stimulates FSH secretion from anterior pituitary
Activin
average age menarche,menopause
menarch: 13
menopause: 45
number of lifetime mature follicles
400 follicles
peak of sexual desire
just before ovulation
helps in fertility
female orgasm
fertilized ovum implanting on uterus
blastocyst
number of hours eggs to be fertilized
24 hours
hours of sperms to be fertilized
1-5 days
site of fertilization
Ampulla of oviduct
cells of the blastocyst that digest and liquifies the endometrium for invasion
trophoblast
nutrient-rich endometrium invaded by trophoblast
decidua
provides nutrients by day 16
placenta
produced by Syncitiotrophoblast
B-HCG
prevents menstruation
causes growth of endometrium
Rescues corpus luteum
produced by fetal adrenal gland
estrogen
produced by
corpus luteum in 1st trimester
placenta by 2nd & 3rd trimester
Progesterone
AKA Human Chorionic Somatomammotropin
Human Placental LActogen
Human Placental LActogen function
- promotes growth of the fetus
- promotes insulin resistance in the mother
- promotes Lipolysis from mother
- index of placental well-being
physiologic changes in pregnancy
weight gain - 24 pounds BMR inc 15% Nutrional demand - Iron, vit D, Vit K CO inc 40% blood volume - 30% o2 usage - inc 20% minute ventilation inc 50% renal tubule reabsorptive capacity for Na, Cl, H2O inc 50% GFR inc 50%
lactation is maintained by
suckling
lactation inhibit
ovulation
what stimulates growth of the male external genital organs
DHT
what substance acts to stimulate Leydig cell production of testosterone in males?
LH
all of the following are functions of estrogen EXCEPT?
a. breast and genital development in females
b. female fat distribution
c. upregulation of estrogen, LH and progesterone receptors
d. increase sex hormone binding globulin
e. none
d. increase sex hormone binding globulin
during the follicular phase of the ovarian cycle, what is the effect of estrogen on the pituitary?
negative feedback
why does lactation not occur during pregnancy?
estrogen and progesterone block prolactin’s effects on the breast