Seizure Disorders Flashcards

1
Q

Types of neurological disorders

A
  1. Vascular disorders
  2. Cancer
  3. Infectious disease:
  4. Neurodegenerative disorders
  5. Demyelinating disorders
  6. Metabolic/toxic disorders
  7. Synaptic disorders
  8. Seizure disorders
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2
Q

What is a seizure?

A

a sudden, uncontrolled electrical disturbance in the brain

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3
Q

What is epilepsy?

A

When an individual two or more seizures within a certain period of time

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4
Q

How long do seizures last?

A

30 seconds to two minutes

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5
Q

What are seizure treatments?

A

most seizure disorders can be controlled with medication

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6
Q

How many people have epilepsy?

A

1.2% of the US population

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7
Q

What are health problems that can arise because of seizures?

A

A) Cognitive disabilities
B) Psychiatric issues
C) Autism
D) Behavior problems
E) Cardiovascular and respiratory disorders
F) Diabetes, obesity

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8
Q

What was the epilepsy patient story by Dr. Rosen

A

He had a women come in with scars on her back. She had seizures and people thought she was possessed so they hit her with sticks.

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9
Q

What is used to diagnose epilepsy and seizures?

A

electroencephalogram (EEG)

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10
Q

What are the classifications of seizures?

A
  1. partial/focal
  2. generalized (begin widespread regions)
  3. unknown onset
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11
Q

What are the subdivisions of partial?

A
  1. simple (conscious)
  2. complex (loss of consciousness and memory)
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12
Q

What are causes of partial seizures?

A

Often unknown but can be because of head injury, brain infection, stroke, tumor

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13
Q

Can partial seizures evolve into general seizures?

A

Yes a focal seizure can later spread and generalize

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14
Q

What distinguishes generalized seizures from partial seizures?

A

They begin with a widespread electrical discharge that involves both sides of the brain at once

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15
Q

What are the subclassifications of generalized seizures?

A
  1. Absence seizures
  2. Myoclonic seizures (sudden jerks)
  3. Atonic seizures (falls)
  4. Tonic-clonic seizures (stiffening followed by jerking)
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16
Q

What causes seizures?

A
  1. Gene mutations in ion channels (channelopathies)
  2. brain injury
  3. Stroke, brain tumor
  4. Infectious diseases
  5. Developmental disorders
17
Q

Mechanisms of focal seizures

A

neurons exhibit paroxysmal depolarizing shift (PDS). PDS is a long lasting depolarization followed by a period of hyperpolarization

18
Q

What are the mechanisms of spread?

A

1) surround inhibition can be overcome causing spread
2. Jacksonian march (follows normal pathways)
3. Spread via repetitive kindling (repeated prolonged experimental stimulation)

19
Q

What are the Pharmacological Treatments?

A

A) Inhibition of Na channels
B) Enhancement of GABA mediated inhibition
C) GABA analogs
D) Block T-type calcium channels
E) Unknown mechanism