sedatives and general anesthetics Flashcards
benzodiazepine MOA
bind to GABAa receptor
GABA agonists
(actually it facilitates GABA to stimulate the GABAa receptor cos it binds a different spot on the receptor)
cells becomes inhibited,
=inhibits feelings of anxiety
benzodiazepine functions
reduce anxiety produce sedation (calming) induce sleep
midazolam
benzodiazepine
very short (
less than 6 hrs
conscious sedation
temazepam
benzodiazepine
short (6-12 hrs)
put u to sleep, treat insomnia
diazepam
benzodiazepine
long (>24 hrs)
manage anxiety, epilepsy, muscle relaxant
thiopental/thiopentone
barbituate
very very very very short acting (10 mins) -gets distributed to other tissues
induction anaesthetic
- desfluorane / isoflurane / sevoflurane
_ methoxyflurane
– (nitrous oxide)
inhaled general anesthetic s
inhaled general anesthetics MOA
block TREK-1 (K+) channel
oppose any tendency to excitation or depolarisation
(in AP, u get K+ channel opening alowing K efflux to bring cell back to resting membrane potential/prevent another excitation)
inhaled general anesthetics properties
more lipid soluble=more potent
more lipid soluble=slower induction/recovery
MAC (minimal alveolar conc)% is
potency
low numbers =high potency
e.g. 0.16=high potency vs 100
blood:gas coefficient is
lipid solubility
high numbers=high potency
eg 12=hihgly soluble
nitrous oxide properties
low blood:gas coefficient
low potency
fastest induction/recovery
methoxyflurane properties
high blood:gas coefficient
high potency
slowest induction/recovery
isoflurane
desflurane
sevoflurane
nitrous oxide
maintenance of
general anaesthesia
methyoxyflurane
not used in gen anaes more in just paramedics in a liquid form for u to breathe in
analgesia in subanaesthetic
doses
