anti-epileptic drugs Flashcards
1
Q
valproate
A
block GABA transaminase
2
Q
vigabatrin
A
block GABA transaminase
3
Q
tiagabine
A
block transporter of GABA
4
Q
diazapam
A
a Benzodiazepine
stimulate GABAa receptors, GABA agonist
5
Q
phenobarbitone
A
a Barbiturate
stimulate GABAa receptors, a GABA agonist
6
Q
carbamazepine
A
block use-dependent Na+ channels
7
Q
phenytoin
A
block use-dependent Nat + channel
8
Q
ethosuximide
A
block T type Ca2+ channel
in absence seizure
9
Q
gabapentin
A
block HSA (high voltage activated) type Ca2+ channel works in partial seizure
10
Q
side effects of phenytoin
A
gum hyperplasia/acne/
hirsuitism
11
Q
side effect of carbamazepine
and valproate
A
car: bonemarrowdepression
valproate: weightgain/alopecia
12
Q
side effects of anti epileptic drugs in pregnancy
A
phenytoin: affects heart/palate
valproate: spina bifida
