antidepressants

Question 1

TCA MOA

Answer 1

tricyclic antidepressants

block reuptake of Noradrenaline

blocks 3 other receptors:
muscarinic
H1
alpha 1-adrenoreceptors

Question 2

TCA side effects

Answer 2

blockade of muscarinic receptors
•dry mouth, blurred vision, urinary retention, constipation

– blockade of H1 receptors
•sedation

– blockade of alpha1‐adrenoceptors
•orthostatic hypotension

also get arrhythmias/heart problems (its cos it raises noradrenaline levles in brain but the heart as well, driving heart harder)

Question 3

desipramine

Answer 3

tricyclic antidepressants

Question 4

SSRI MOA

Answer 4

specifically block the re‐uptake of 5HT

Question 5

SSRI side effect

Answer 5

GI upset

cos 90% of the bodys 5HT is in the enterochromaffin cells in the GIT

Question 6

SSRI contraindication

Answer 6

st johns wort

Question 7

fluoxetine

Answer 7

SSRI

Question 8

Irreversible MAOa inhibitor MOA

Answer 8

MAOa breaks down NA and 5HT

so u inhibit it permanently
enzyme activity returns with resynthesis of new enzymes 2-3 wks

Question 9

Irreversible MAOa inhibitor side effects

Answer 9

cheese reaction

insomnia
postural hypotension
atropine-like side effects
sexual dysfunction (e.g. low libido)

Question 10

tranylcypromine

Answer 10

Irreversible MAOa inhibitor

Question 11

reversible MAOa inhibitor (RIMAs) MOA

Answer 11

bind to MAOa reversibly

no cheese reaction

Question 12

moclobamide

Answer 12

reversible MAOa inhibitor