parkinson and huntington drugs Flashcards
1
Q
carbidopa
A
peripheral DDC inhibitor
2
Q
benserazide
A
peripheral DDC inhibitor
3
Q
side effect of levodopa
A
dyskinesia (abnormalinvoluntarymovements)
4
Q
tolcapone, entacapone
A
COMT inhibitor
5
Q
apomorphine
A
DA agonist
stimulate D2 receptors
6
Q
bromocriptine
A
DA agonist
stimulate D2 receptors
7
Q
side effects of DA agonists
A
nausea, vomitting
hypotension
less dyskinesia
psychological effects
8
Q
selegiline
A
MAO-B inhibitor
no cheese reaction
9
Q
benzotropine
A
muscarinic antagonist
10
Q
amantidine
A
not sure how it helps parkinons
11
Q
pathophys for parkinsons
A
loss of dopanergic neurons in substantia nigra
=less dopamine in striatum
12
Q
pathophys for huntingtons
A
loss of GABA neurons in striatum (which normally inhibit dopamine)
=dopamine hyperactivity
13
Q
baclofen
A
GABA agonist
14
Q
chlorpromazine
A
DA antagonist
