Sedative-Hypnotic Medications Flashcards
What is the main receptor we care about when talking about effects of benzodiazepines and barbiturates?
GABAa receptor
What is the MOA of benzodiazepines?
increase chloride influx, increase hyperpolarization, and decreases number of action potentials (CNS depression)
What is the BBW for Benzodiazepines?
CNS depression when combined with other drugs (ethanol)
Which benzodiazepine has the fastest onset?
Diazepam (has an active metabolite)
Which benzodiazepine has the slowest onset?
Oxazepam
What is Alprazolam indicated for?
anxiety, panic disorder with or without agoraphobia
What is the contraindication for alprazolam?
acute narrow angle glaucoma
(star) what benzodiazepine has the longest half life?
Diazepam
(star) What drug is giving to manage benzodiazepine overdose?
Flumazenil
What is a ultra-short acting barbituate used for anesthesia induction?
thiopental
What is a short acting barbiturate used for insomnia treatment?
secobarbital
What is a long acting barbiturate used for treating seizures?
phenobarbital
Which drug is used for short term treatment of insomnia?
Zaleplon
Which drug is used for shot term treatment of insomnia specifically because of difficulties with sleep initiation?
Zolpidem
