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Neuro/Psych Exam 1 > Opioids > Flashcards

Opioids Flashcards

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1
Q

What is the MOA of Opioid Drugs?

A

Opioid receptor binding leading to decreased ascending pain pathways

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2
Q

What GI symptom is caused from Opioid drugs?

A

Constipation

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3
Q

Why do would we be concerned about the side effects of constipation with opioid drugs?

A

If a patient has unstable angina or is post MI then we do not want them straining to poop as it could stress their heart.

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4
Q

What is a systemic side effect of opioid drugs?

A

hypotension (orthostatic/syncope)

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5
Q

What CNS side effect occurs with opioid drugs?

A

CNS depression

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6
Q

What is the BBW for opioid drugs?

A

Severe respiratory depression

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7
Q

In comparison to morphine how much stronger is fentanyl?

A

90x - holy buckets that a lot

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8
Q

Which opioid drug exerts its effects only in the GI system as an anti-diarrheal?

A

Loperamide

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9
Q

What drug can be given to help patients combat alcohol, opioid, heroin addiction? has also shown to cause weight loss…

A

Naltrexone

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10
Q

Of the drugs given to help combat opioid addictions which was in a full agonist vs a partial agonist?

A

Full - methadone

partial - buprenorphine

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11
Q

Morphine overdose leads to what fatal symptoms?

A

Respiratory depression

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12
Q

What are the drug-drug interactions that occur with opioids and sedative-hypnotics?

A

increased CNS depression, particularly respiratory depression

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13
Q

What are the drug-drug interactions that occur with opioids and antipsychotic agents?

A

Increased sedation. Accentuation of cardiovascular effects .

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14
Q

What are the drug-drug interactions that occur with opioids and MAOIs?

A

Contraindicated with all opioid analgesics because of hyperpyrexic (high fever) coma; HTN has also been reported (hypertensive crisis is a bad side effect of MAOIs)

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15
Q

What is the MOA of Naloxone?

A

pure opioid antagonist that competes and displaces opioids at the receptor site

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16
Q

What is Naloxone used for?

A

Opioid overdose - competes for mu receptor

17
Q

If someone comes into ER that is a known drug user and is in respiratory depression what drug can be given to confirm opioid overdose?

A

Naloxone

18
Q

What is a concern of giving Naloxone?

A

Withdrawal symptoms

19
Q

What is the MOA of Naltrexone?

A

pure opioid antagonist, highest affinity for mu receptor

20
Q

What are the indications for Naltrexone?

A

Alcohol use disorders and opioid dependence

21
Q

What is a concern in giving Naltrexone?

A

Withdrawal symptoms

22
Q

What drug are patients drinking in smoothies if they cant get opioids?

A

Loperamide, as many as 400-500 tablets in a smoothie

23
Q

What are side effects of oxycodone?

A

Face, eyes, mouth, tongue, lips, throat - swelling
Respiratory depression
CNS - hallucinations, confusion, fainting, dizziness
Skin- hives, rash
Heart - variable fast or slow
MSK - seizures

24
Q

Indications for Morphine sulfate?

A

management of pain unresponsive to non-narcotic analgesics

25
Q

Contraindications of Morphine sulfate?

A

Hypersensitivity or allergy to morphine

26
Q

What are warning or precautions for Morphine sulfate?

A

Dosing errors based on formulation
Respiratory depression
CNS toxicity
CNS depressants - respiratory depression

27
Q

Adverse effects of morphine sulfate?

A

sedation, lightheaded, dizziness, nausea, vomiting, constipation

28
Q

What is Buprenorphine used for?

A

opioid dependence tx

29
Q

What is a warning/precaution for Buprenorphine use?

A

Has been shown to cause significant respiratory depression and death when paired with IV benzodiazepines

30
Q

drug interactions of buprenorphine?

A

Just need to monitor patients on CYP3A4 inhibitors or inducer so we can adjust up or down the dose.

Neuro/Psych Exam 1 (21 decks)

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