SCLC, thymic, mesothelioma

Question 1

Limited stage SCLC treatment

Answer 1

Surgery followed by adjuvant cis/etoposide for T1-2 N0

Definitive chemoRT with cisplatin + etoposide for all others

*Don’t give G-CSF with chemo

Question 2

1st line extensive stage SCLC treatment

Answer 2

Cis/carbo + etoposide + atezo/durva
Followed by maintenance immunotherapy

Consider prophylactic cranial irradiation and/or consolidative thoracic radiation

Question 3

2nd line extensive stage SCLC treatment

Answer 3

Consider re-treatment with platinum + etoposide if relapse > 6 months after finishing 1st line
Topotecan
Lurbinectedin
Other single agent chemo

Question 4

Thymoma/thymic carcinoma management

Answer 4

Surgical resection if able

Cisplatin-based chemo if not resectable or if recurrent

Question 5

Mesothelioma chemotherapy

Answer 5

Cisplatin + pemetrexed +/- bev

Ipi/nivo

Question 6

Management of localized bronchopulmonary typical/atypical carcinoid

Answer 6

Resection + mediastinal node sampling
No adjuvant therapy for low grade (typical carcinoid)
Consider adjuvant cis/carbo + etoposide or temodar for stage III intermediate grade (atypical carcinoid)

Question 7

Management of unresectable bronchopulmonary typical carcinoid (low grade)

Answer 7

Observation if asymptomatic
Octreotide/lanreotide if SSR+
Everolimus
Temodar +/- capecitabine
RT

Question 8

Management of unresectable bronchopulmonary atypical carcinoid (intermediate grade)

Answer 8

Observation if asymptomatic
RT +/- concurrent cis/carbo + etop
Cis/carbo + etop 
Temodar +/- capecitabine
Octreotide/lanreotide if SSR+
Everolimus