Prostate Flashcards
nmCRPC treatment
Enzalutamide
Darolutamide
Apalutamide
mCSPC treatment
Abiraterone
Enzalutamide
Apalutamide
Docetaxel- high volume disease
High volume disease definition
4 or more bone mets with at least 1 outside the axial skeleton or presence of visceral mets
Cabazitaxel AEs
Hypersensitivity
Myelosuppression/febrile NTP
Neuropathy
Cystitis/hematuria due to radiation recall
Cabazitaxel indication
mCRPC after prior docetaxel
Sipuleucel-T AEs
Fever/chills
Headache
Fatigue
Infusion reactions
Radium-223 indication
mCRPC with symptomatic bone mets and no visceral disease (no LNs > 3cm)
Small cell prostate treatment
Cis/carboplatin + etoposide or carboplatin + docetaxel
Abiraterone AEs
HTN Fluid retention Hypokalemia Increased LFTs Fatigue Hot flashes
Enzalutamide AEs
HTN Edema Hot flashes Fatigue Dizziness Cognitive dysfunction ?seizures
Darolutamide AEs
Fatigue
Rare neutropenia
Increased LFTs
Apalutamide AEs
Rash (common) Elevated cholesterol/TG Hyperglycemia Hypothyroidism HTN Edema Falls Fatigue ?seizures
Bone agent indications
CRPC with or without bone mets
Osteopenia/osteoporosis and on long term ADT
