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Onc boards > Leukemia drugs- mechanisms and indications > Flashcards

Leukemia drugs- mechanisms and indications Flashcards

1
Q

Midostaurin

A

FLT3-ITD inhibitor

AML induction therapy

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2
Q

Gilteritinib

A

FLT3 inhibitor

R/R AML

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3
Q

Enasidenib

A

IDH2 inhibitor

R/R AML

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4
Q

Ivosidenib

A

IDH1 inhibitor
AML induction (unfit)
R/R AML

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5
Q

Venetoclax

A

BCL-2 inhibitor

Unfit AML induction, R/R AML

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6
Q

Gemtuzumab ozogamicin

A

Anti-CD33 antibody linked to cytotoxic calicheamicin derivative
CD33+ AML induction or R/R

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7
Q

Glasdegib

A

Headgehog pathway inhibitor

Combined with low dose cytarabine for unfit AML induction

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Onc boards (24 decks)

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