Anal

Question 1

Locoregional disease treatment

Answer 1

Definitive chemoRT with mitomycin + 5-FU/cape
RT boost for T3/4 or N+ disease

*Tumor regression can happen up to 26 weeks after completing chemoRT

Question 2

Recurrent/metastatic disease

Answer 2

Surgical resection for locally recurrent/persistent disease
1st line metastatic options include carbo/paclitaxel, 5-FU + cisplatin/oxaliplatin
2nd line metastatic tx is nivo or pembro