Non-hodgkin lymphoma

Question 1

Difference between Mantle cell lymphoma and CLL

Answer 1

CLL is CD23+ and CD20+(dim)
MCL is CD23-, CD20+(strong)

Both are CD5+

Question 2

Follicular lymphoma treatment indications (GELF criteria)

Answer 2

3 nodal sites > 3cm
Any mass > 7cm
Systemic symptoms
Splenomegaly
Cytopenias
Effusions/ascites

Question 3

Limited stage follicular treatment

Answer 3

Observation
Ritux
Involved field RT

Limited stage = on 1 side of diaphragm

Question 4

Advanced stage/high tumor burden follicular treatment

Answer 4

Rituximab + bendamustine
R-CHOP
R-lenalidomide

Question 5

Follicular immunophenotype

Answer 5

CD20+, CD5-, CD23-, CD10+, BCL-6+

Question 6

Marginal zone immunophenotype

Answer 6

CD20+, CD5-, CD10-, CD23-, BCL-6-, cyclin D1-

versus CLL is typically CD5+, CD23+

Question 7

Difference between marginal zone lymphoma and lymphoplasmacytic lymphoma

Answer 7

MYD88 positive in LPL and negative in MZL