Schizophrenia Flashcards
Accumbens
part of the reward circuit in the brain, affected by schizophrenia
Aetiologically Heterogeneous
means there are a combination of different factors that can cause something
Agonist
a substance which initiates a physiological response when combined with a receptor
Agranulocytosis
a side effect of Clozapine where production of white blood cells is lowered, leaving the patient potentially lethally vulnerable to infections
Allen et al (2007)
scanned patients with auditory hallucinations, compared with a control and found lower activation levels in the superior temporary gyrus in the hallucination group, showing that the superior temporal gyrus is a neural correlate for auditory hallucinations
Amphetamines
dopamine agonists
Andreason (1982)
first to describe avolition in schizophrenia
Antagonist
a substance which interferes wit or inhibits physiological actions of another
Anterior Cingulate Cortex
tracks progression of goal-directed action sequences, affects schizophrenia
Anti-Psychiatrists
a movement based on the view that psychiatric treatment can be often more damaging than helpful to patients
Avatar Therapy
where psychologists create faces of what a patient believes their voices look like and give the patient the opportunity to challenge them
Bateman (1956)
suggested the Double Bind Theory
Beck et al (1961)
found that agreement on diagnosis for 153 patients where each was assessed by two psychiatrists, was only 54% due to vague diagnostic criteria and inconsistencies in techniques to gather data
Berger (1965)
found that schizophrenics reported a higher recall of double bind statements from their mothers than non-schizophrenics, however, evidence may not be reliable as patient’s recall may be affected by their schizophrenia
Betall (1993)
suggests abandoning the schizophrenia diagnosis and instead treating each symptom as a disorder in its own right with separate treatment and diagnosis
Bipolar Disorder
a mental disorder characterized by periods of depression and periods of abnormally elevated mood that each last from days to weeks
Buckley et al (2009)
found that around half of all patients diagnosed with schizophrenia also had a diagnosis of depression, questioning the ability to differentiate between the two and diagnosed accurately. It could be that very severe depression can present as schizophrenia because it looks a lot like it.
Candidate Genes
individual genes associated with risk of inheritance
Catatonic Behaviour
characterised by abnormal motor activity where a person may experience loss or motor skills or extreme hyperactive motor activity
Caudate/Associative Striatum
central to associative learning and encodes action-specific value signals. In schizophrenia, this causes deficits in outcome-specific devaluation
CBT
Cognitive Behaviour Therapy
aims to change patients thought processes, such as challenging negative thoughts, and uses behavioural techniques to help patients have a better quality of life
Central Control
the cognitive ability to suppress automatic response whilst we perform deliberate actions instead. Disorganised speech and thought disorder could result from inability to suppress automatic thoughts and speech triggered by other thoughts
Chadwick and Birchwood (1996)
studied DD, an economics graduate who frequently heard the voice of the devil, claiming to use her telepathic powers to control the prime minister, making him do things that would destroy the British economy, making her feel guilty whenever the economy took a turn for the worse
Cheniaux et al (2009)
investigated the reliability of schizophrenia diagnosis by comparing patients diagnosed with the DSM and patients diagnosed with the ICD, found poor reliability and that patients were more likely to be diagnosed under ICD criteria
Chlorpromazine
a typical antipsychotic used since the 1950s, acts as a dopamine antagonist to reduce positive symptoms, as well as having a sedative effect
Classification of Mental Disorders
the process of organising symptoms based on which symptoms cluster together in sufferers
Clozapine
a typical antipsychotic used since the 1970s, affects dopamine, serotonin and glutamate receptors, so can improve mood as well as positive symptoms, but can cause agranulocytosis
Cochrane and Sashidharan
examined diagnosis rates of schizophrenia in the UK and found that those of African-Caribbean origin were seven times more likely to be diagnosed despite rates of schizophrenia in the Caribbean, they are no higher than the UK
Cognitive Explanations
cognitive explanation focuses on mental processes. Schizophrenia is associated with an array of abnormal information processing; these abnormalities can be used to explain why a person experiences schizophrenia
Comorbidity
the occurrence of two or more illnesses together, for example when a person has both schizophrenia and a personality disorder. When two conditions are frequently diagnosed together, it calls into question the validity of classifying the two separately
Cooper et al (1972)
found that in US, patients diagnosed with schizophrenia rose from 20% in 1930s to 80% in 1950s whereas in London, diagnosis rate remained constant throughout same period
Copeland (1971)
gave 124 US and 194 British psychiatrists a description of a patient. 69% of the US psychiatrists diagnosed schizophrenia but only 2% of British psychiatrists diagnosed schizophrenia.
Coping Strategy Enhancement
a form of CBT for schizophrenia developed by Tarrier (1990) where the therapist develops a rapport with the patient, identifies triggers for their symptoms and helps them find ways of dealing with these using behavioural and cognitive techniques
Cotton et al (2009)
suggested there is gender bias in schizophrenia and that women typically function better than men and are more likely to work and have good family relationships despite having schizophrenia
Crow (1985)
suggested that schizophrenia is too broad a term and there are two distinct versions, which respond to different treatments but some people do not fit neatly into one category
Type 1 Schizophrenia
acute disorder characterised by positive symptoms, described only by Crow
Type 2 Schizophrenia
chronic disorder characterised by negative symptoms, described only by Crow
Curran et al (2004)
found that overdoses of amphetamines produced schizophrenia-like symptoms and that schizophrenia symptoms have abnormally large responses to low amphetamine responses
Davis
added cortical hypodopaminergia to the dopamine hypothesis
Davison and Neale (1994)
in Asian cultures, a person experiencing some emotional turmoil is praised & rewarded if they show no expression of their emotions whereas in certain Arabic cultures, the outpouring of public emotion is understood and often encouraged. This can cause behaviours to be seen as abnormal when they aren’t
Derailment
where schizophrenic people go off on a tangent, caused by deficits in central control
Diathesis-Stress Model
suggests that both vulnerability and a trigger are necessary for the onset of schizophrenia
Dissociation
a mental process where a person disconnects from their thoughts, feelings, memories or sense of identity
Dopamine
a neurotransmitter that generally has an excitatory effect and is associated with the sensation of pleasure. Unusually high levels are associated with schizophrenia and abnormally low levels with Parkinson’s disease
DBH
Dopamine-Beta-Hydroxylase
breaks down dopamine, abnormally low levels found in schizophrenia patients
Dopamine Hypothesis
theory that abnormal levels of dopamine cause symptoms of schizophrenia
Outdated Dopamine Hypothesis
states that schizophrenia is caused by high levels of dopamine activity in the cortex, subcortex and Broca’s area, caused by an excess of dopamine or an excess of dopamine receptors, causing neurones that use dopamine fire too often and transmit too many messages, explaining positive symptoms
Updated Dopamine Hypothesis
states that schizophrenia is simultaneously caused by low levels of dopamine in the prefrontal cortex which is associated with thinking and decision making, explaining negative symptoms
Dorsolateral PFC
mediates action-value comparisons and action control, affected by schizophrenia
Double Bind Theory
where a person is given mutually contradictory signals by another person, placing them in an impossible situation, causing internal conflict. Schizophrenic symptoms represent an attempt to escape from the double bind, developed by Bateman (1956)
Double Bind Theory
where a person is given mutually contradictory signals by another person, placing them in an impossible situation, causing internal conflict. Schizophrenic symptoms represent an attempt to escape from the double bind
Ellason and Ross
found that people with dissociative identity disorder generally have more schizophrenia symptoms than schizophrenic people
Elizabeth Cochrane
a journalist who pretended to be mad in order to infiltrate an asylum in the 1800s. She found that after being admitted, the saner she acted. the more insane they thought she was. She later wrote a book on her experiences, criticising the psychiatry system, claiming doctors couldn’t tell the difference between ill or well people.
Ethnographic Study
explores cultural phenomena from the point of view of the subject of the study
Experience Sampling
form of electronic diary keeping that asks people to fill in questionnaires to snapshot what they’re like in a particular moment to see what circumstances trigger hallucinations/paranoia
Expressed Emotions
negative attitudes, in the form of criticism, hostility and emotional overinvolvement, demonstrated by family members toward a person with a mental disorder
Family Dysfunction
abnormal processes within the family such as poor family communication, cold parenting and high levels of expressed emotion
Family Systems Theory
a psychoanalytical tradition that looks at the influence of family on abnormal behaviour and systems thinking, for example, a family can be seen as a set of entities where everyone interacts with each other, and if one person starts to behave abnormally, the behaviour may be a manifestation of a problem occurring within the wider family system
Family Therapy
a psychological therapy carried out with some or all members of a family with the aim of improving communication and reduce the stress of living as a family, primarily helps reduce relapse rates
First-Rank Symptoms
a group of symptoms characteristic of schizophrenia but rarely found in other mental disorders
Frida Fromm-Reichmann (1948)
listened to accounts of her clients’ childhoods and suggesting an ineffectual father and cold, domineering mother, creating a family climate characterised by tensions and secrecy, leading to distrust, then paranoid delusions and eventually schizophrenia
Frith et al (1992)
identified two forms of dysfunctional thought processes in schizophrenia
Central Control
cognitive ability to supress automatic responses whilst we perform deliberate actions instead; disorganised speech and thought disorder result from inability to suppress automatic thoughts and speech triggered by thoughts
Metarepresentation
the cognitive ability to reflect on thoughts and behaviours allowing insight into intentions, goals and interpreting actions of others. Dysfunction in metarepresentation disrupt ability to recognise thoughts and actions as your own, explaining hallucinations, delusions and thought insertion
Genetics
genes consist of DNA strands are inherited. DNA produces instructions of physical features of an organism which may impact on psychological features, eg neurotransmitter levels and size of brain structure
Glutamate
a neurotransmitter that schizophrenic people have been found to have a deficiency of
Globus Pallidus
part of the basal ganglia associated with schizophrenia, Parkinson’s and Huntington’s
Goldman-Rakic et al (2004)
identified low levels of dopamine in the prefrontal cortex which is associated with thinking and decision-making, explaining negative symptoms
Gottesman (1991)
carried out a comprehensive review of family studies to investigate causes of schizophrenia
Schizophrenia Rates in the General Population
1%