SCC Flashcards
What is SCC?
Squamous cell carcinoma
Fast growing malignant tumour arising from keratinocytes
What are risk factors for developing SCC?
Age UV radiation Genetics Immunosuppression Chronic wounds Viral infections Pre-malignant lesions
What pre-malignant lesions are associated with SCC?
Actinic keratosis
Bowen’s disease
Keratoacanthoma
Leukoplakia
What is actinic keratosis?
Scaly spot found on sun-damaged skin - due to abnormal skin cell development due to DNA damage by UVB
What is actinic keratosis also known as?
Solar keratosis
What is Bowen’s disease?
SCC confined to the epidermis
Flat edged slightly pigmented scaly plaques
What is keratoacanthoma?
Skin lesion that erupts in sun damaged skin
Grows up like a volcano then shrinks
What is leukoplakia?
Formation of white patches in the mouth
What are clinical features of SCC?
Lesion
- nodular
- ulcerated
- painful
- central mass of keratin
What are the types of SCC?
Ulcerative
Verrucous
Subungual
Marjolins
How are SCC investigated?
Biopsy
How are SCC managed?
Refer to dermatology
Surgical excision
Topical immunotherapy
Cryotherapy
Radiotherapy
What is a Marjolin’s ulcer?
Growth of an SCC in an ulcer or scar
