Bullous Pemphigoid Flashcards
1
Q
What is bullous pemphigoid?
A
Autoimmune sub epidermal blistering skin diseae
2
Q
What are the features of bullous pemphigoid?
A
Tense fluid filled blisters
Itchy
3
Q
What can trigger bullous pemphigoid?
A
Injury Infection Drugs - gliptins - abx - furosemide
4
Q
What is the pathophysiology of bullous pemphigoid?
A
Attack on basement membrane of epidermis by IgG +/-IgE and T lymphocyres
Target type XVII collagen - associated with hemidesmosomes
5
Q
How is bullous pemphigoid distinguished from pemphigus vulgaris?
A
Bullous pemphigoid = Nikolsky -ve
Pemphigus vulgaris = Nikolsky +ve
6
Q
What is the Nikolsky sign?
A
Slight rubbing of the skin results in exfoliation of the outer layer
7
Q
How is bullous pemphigoid diagnosed
A
Refer to dermatology
Skin biopsy
8
Q
How is bullous pemphigoid managed?
A
Oral corticosteroid + PPI
+/-
- topical steroid
- immunosuppression
- antibiotics
