Salivary Glands and Mucosal Immunity

Question 1

produced in the submandibular gland; functions in barrier protection

Answer 1

MG1

Question 2

____ affects anti-oxidant activity, increases IgA and increases oral cancer; also increases periodontal disease

Answer 2

Smoking

Question 3

alpha defensins are produced by ______ granulocytes

Answer 3

neutrophil

Question 4

sympathetic saliva control comes from ______

Answer 4

superior cervical ganglion

Question 5

major protein of saliva

Answer 5

alpha amylase

Question 6

produced in acini of submandibular and labial glands; interacts with streptococci and promotes their agglutination

Answer 6

MG2

Question 7

Which salivary gland needs stimulation to produce and dominate

Answer 7

parotid

Question 8

____ help exclude microbes from surfaces and clear from oral cavity

Answer 8

prps

Question 9

Inhibits pptn. of calcium phosphate salts from saliva and critical for remineralisation of teeth; Binding of bacteria likely leads to aggregation& clearance towards the stomach

Answer 9

statherin

Question 10

____ form viscous coating on epithelial surfaces; microbes excluded from surface due to steric hindrance from the dense glycosylation later

Answer 10

mucins

Question 11

_____ binds bacteria, directly inhibits certain bacteria, binds bacterial LPS, and may inhibit viruses

Answer 11

alpha amylase

Question 12

sympathetic saliva stimulation elicits _________ (neurotransmitter) which acts on adrenergic receptors

Answer 12

noradrenaline

Question 13

parotid (anicar or serous), sub-lingual and sub-mandibular (mixed) comprise the ______ salivary glands

Answer 13

major

Question 14

_____ is converted to ammonia by bacteria- improves buffering and protects against caries

Answer 14

Urea

Question 15

Which salivary glands are continuously active?

Answer 15

Submandibular, sublingual, and minor glands

Question 16

parasympathetic stimulation of saliva comes from _____

Answer 16

medulla (facial and glossopharyngeal nerves)

Question 17

High molecular weight, heavily glycosylated proteins;produced by epithelial tissues; secreted onto mucosal surfaces or as component of saliva; bind to pathogens as part of the immune system; Prevent adherence of oral microbes to the enamel pellicle and inhibits their growth, reducing caries

Answer 17

Mucins

Question 18

sebaceous glands containing lipids

Answer 18

fordyce’s granules

Question 19

_____ is used to collect saliva stimulated with a lemon drop, used to determine salivary flow rate

Answer 19

Lashley cup

Question 20

(mixed)- serous at lips and mucoid towards back of the mouth comprise the ______ salivary glands

Answer 20

minor

Question 21

1-10% of salivary antibodies, monomeric, serum derived

Answer 21

IgG

Question 22

Salivary ______ consists of lipids in saliva

Answer 22

lipidome

Question 23

cys protease inhibitors, block bacterial and parasitic protozoan proteases, 7 present in saliva; highest concentrations found in submandibular saliva

Answer 23

cystatins

Question 24

lubrication, inhibition of bacterial growth and prevention of biofilm and caries, digest food, facilitate swallowing, stabilize teeth, neutralize acids to prevent caries are all functions of

Answer 24

saliva

Question 25

Secreted by parotid, SL, & SM glands;Broad-spectrum antibacterial, antifungal, & antiviral properties; Act on microbial membranes

Answer 25

Histatins

Question 26

Salivary ______ consists of proteins and peptides in saliva

Answer 26

proteome

Question 27

____ are present in whole saliva, GCF, broad antibacterial, antifungal and antiviral activities, also immune activator and modulatory activities

Answer 27

salivary defensins

Question 28

T/F: Stimulation of the salivary glands-reduces the protein conc 20% but increases NaCl x 10 and doubles NaHCO3 conc. -more alkaline and helps prevent caries

Answer 28

True

Question 29

clear liquid with a low protein concentration

Answer 29

saliva

Question 30

_____ (parasympathetic) stimulates M3 muscarinic receptors

Answer 30

acetylcholine

Question 31

basic prp bind ____

Answer 31

fungi and viruses

Question 32

______ results in decreased blood flow, decreased saliva by acinar cells, and increased protein in saliva

Answer 32

sympathetic saliva stiumlation

Question 33

beta defensins are produced by ______

Answer 33

mucosal cells

Question 34

unstimulated saliva is dominated by

Answer 34

submandibular gland

Question 35

acidic prp bind _____

Answer 35

bacteria

Question 36

_____ contains inflammatory mediators, tissue breakdown products, markers of oxidative stress, enzymes, and mediators of bone homeostasis

Answer 36

GCF

Question 37

How much saliva do you produce per day?

Answer 37

1 liter per day

Question 38

major fraction of salivary proteins, highly phosphorylated, some glycosylated, highest concentration found in parotid saliva

Answer 38

proline rich proteins (prp)

Question 39

_____ results in increased blood flow to glands, increased saliva via acinar cells, increased bicarbonate via ductal cells, increased saliva flow that is more watery

Answer 39

parasympathetic innervation

Question 40

90-98% of salivary antibodies; dimeric or polymeric; produced by salivary gland; 15% is derived from serum and these are monomeric

Answer 40

Secretory immunoglobulin A (sIgA)

Question 41

glycosylated prps bind _____

Answer 41

bacteria and viruses