Regulation of Gene Expression

Question 1

DNA sequence that binds TFIIB; helps to direct RNA pol binding

Answer 1

BRE

Question 2

provide access to components of nucleotide bases in the core of DNA

Answer 2

minor and major grooves

Question 3

Protein capable of regulating transcription of a gene

Answer 3

Transcription factor

Question 4

______ are proteins involved in regulating gene expression that are important in unwinding

Answer 4

chromatin remodeling proteins

Question 5

DNA sequence that modulates DNA transcription in an orientation and location independent fashion

Answer 5

Enhancer

Question 6

DNA sequence that binds TFIID; helps to direct RNA pol binding

Answer 6

DPE

Question 7

a segment of DNA that is transcribed into RNA and its associated transcriptional control regions.

Answer 7

Gene

Question 8

DNA sequence or promoter that serves to bind transcriptional regulatory proteins

Answer 8

Nuclear Response Element

Question 9

process that is seen in tooth development that is characterized by specific patterns of gene expression expressed at different times

Answer 9

reciprocal induction

Question 10

Transcription factor that increases gene expression

Answer 10

Activator

Question 11

The _______ is capable of promoting both DNA binding and dimerization

Answer 11

Leucine zipper

Question 12

DNA regulatory sequences can be located at great distances relative to the start site of transcription like in the 5’ or 3’ flanking regions and in introns in _______

Answer 12

eukaryotes

Question 13

Do autosomes and X chromosomes undergo recombination?

Answer 13

Yes

Question 14

transcription factor with a bound Zn atom associated with the protein that is required for the protein to achieve the proper confirmation to bind DNA and/or regulate transcription.

Answer 14

Zinc finger

Question 15

Do Y chromosomes undergo recombination?

Answer 15

No

Question 16

What are the 5 signaling mechanisms that are used in animal development?

Answer 16

WNT, TGF-B, RTK, Hedgehog, and Notch

Question 17

In _______, the repressor and activator binding sites are generally closely juxtaposed to the RNA Pol binding site

Answer 17

prokaryotes

Question 18

Protein that forms a complex with DNA, may or may not have transactivating ability

Answer 18

DNA binding protein

Question 19

structural feature in transcription factors consisting of α helices bound by a looping stretch of amino acids

Answer 19

Helix-loop-helix

Question 20

contains start site of transcription for many RNA pol II genes, binds TFIID

Answer 20

INR

Question 21

Located 25-30 bp 5’ of the start site of transcription, bind TBP subnit of TFIID

Answer 21

TATA box

Question 22

allows us to identify causal mutations in those cases where a large family suitable for linkage analysis is not available

Answer 22

Exome sequencing

Question 23

Transcription factor that decreases gene expression

Answer 23

Repressor

Question 24

aa’s form _____ bonds with certain nucleotide bases in the grooves of DNA

Answer 24

hydrogen

Question 25

Human gene names are italicized and ________

Answer 25

capitalized

Question 26

All letters in a gene name are _____

Answer 26

italicized

Question 27

Two proteins each with an α-helix (formed largely by consecutive leucine residues) form a Y-shaped coiled-coil structure. Results in both protein and DNA binding.

Answer 27

Leucine zipper

Question 28

______ are proteins involved in regulating gene expression that decrease the level of transcription

Answer 28

repressors/corepressors

Question 29

Coactivator for the WNT signaling pathway

Answer 29

B-catenin

Question 30

______ are proteins involved in regulating gene expression that are important for transcriptional complex

Answer 30

mediators and DNA binding proteins

Question 31

Transcription control, RNA processing control, RNA transport and localization control, Translation control, mRNA degradation control, and protein activity control are all ______

Answer 31

Levels of Control of Eukaryotic gene expression

Question 32

____ are proteins involved in regulating gene expression that increase the level of transcription

Answer 32

activators/coactivators

Question 33

DNA binding motif consisting of two α helices joined by a short stretch of amino acids

Answer 33

Helix-turn-helix