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aNeuro Exam I- Lindsey's > Rotation: Pharm > Flashcards

Rotation: Pharm Flashcards

1
Q

D1-D2 direct agonist plus indirect agonist (releaser)

A

dopamine

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2
Q

Name 2 nicotinic receptor agonists.

A
  1. ACh
  2. nicotine
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3
Q

Name the SNS and PNS receptors in the GI/GU.

A

M α1 β2

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4
Q

Adrenergic Agonist; α 1, α2, β1

A

NE

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5
Q

Pralidoxime

A

cholinesterase reactivator (antidote for organophosphate poisoning)

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6
Q

Name the SNS and PNS receptors in the kidneys.

A

β1

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7
Q
  1. List the precursors and key enzymes for the synthesis and transporters involved in the storage of acetylcholine and NE.
A
  • ACh synthesis= via choline acetyltransferase
  • storage = vesicular monoamine transporter (VMAT)
  • release = decreased by botox, increased by black widow spider toxin
  • termination = AChE
  • NE synthesis = via tyrosine hydroxylase
  • storage = vesicular monoamine transporter (VMAT)
  • release = VSCC
  • termination = MAO
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8
Q

Pilocarpine

A

muscarinic receptor agonist

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9
Q

Name the SNS and PNS receptors in the BVs.

A

M (not innervated) α1 β2

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10
Q

Adrenergic Agonist; α 1, α2, β1, β2 (nonselective)

A

epinephrine

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11
Q

Name the SNS and PNS receptors in the adrenal medulla.

A

Nn

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12
Q

Dopamine

A

D1-D2 direct agonist plus indirect agonist (releaser)

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13
Q

Physostigmine

A

AChE Inhibitor

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14
Q

Botulinum toxin

A

inhibits ACh release

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15
Q

Nicotine

A

nicotinic receptor agonist

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16
Q
  1. Describe the synaptic mechanisms by which acetylcholine and NE are inactivated at a synapse.
A
  • diffusion
  • reuptake
  • destruction (AChE)
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17
Q

Name a Muscarinic Receptor Antagonist.

A

atropine

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18
Q

This inhibits acetylcholine release.

A

botulinum toxin

19
Q

What is the antidote to SLUDGE s/s?

20
Q
  1. Describe the receptors and signal transduction systems for acetylcholine and NE.
A
  • ACh = ionotropic or metabotropic receptors
  • NE = GPCRs
21
Q

Bethanechol

A

muscarinic receptor agonist

22
Q

Name an NMJ depolarizing blocker.

A

succinylcholine

23
Q

This is the antidote for organophosphate poisoning.

A

Pralidoxime

24
Q

Edrophonium

A

AChE Inhibitor

25
Q

Name the SNS and PNS receptors in the lungs.

26
Q

Norepinephrine

A

Adrenergic Agonist; α1, α2, β1

27
Q

What does SLUDGE mean, and what does it stand for?

A

adverse reactions to direct-acting muscarinic receptor drugs

S = salivation

L = lacrimation

U = urination

D = defication

G = GI (cramping, emesis, nausea)

E = eye (miosis)

28
Q

Atacurium

A

NMJ competitive blocker (non-depolarizing) (-curare)

29
Q

Name 3 muscarinic receptor agonists.

A
  1. ACh
  2. Bethanechol
  3. Pilocarpine
30
Q

Succinylcholine

A

NMJ depolarizing blocker

31
Q

What are the anticholinergic/antimuscarinic side effects?

A

no pee, no see, no spit, no shit

32
Q

Name 4 AChE inhibitors.

A
  1. Physostigmine
  2. Neostigmine
  3. Edrophonium
  4. Organophosphates
33
Q

Neostigmine

A

AChE Inhibitor

34
Q

Name the SNS and PNS receptors in the eyes.

35
Q

Epinephrine

A

Adrenergic Agonist; α1, α2, β1, β2 (nonselective)

36
Q

Name 2 NMJ competitive blocker (non-depolarizing).

A

Atacurium; Rocuronium

37
Q

Name the SNS and PNS receptors in the heart.

38
Q

Name a cholinesterase inhibitor. What is it used for?

A

Pralidoxime; antidote for organophosphate poisoning

39
Q

Acetylcholine

A

muscarinic receptor agonist

40
Q

Acetylcholine

A

nicotinic receptor agonist

41
Q

Rocuronium

A

NMJ competitive blocker (non-depolarizing) (-curare)

42
Q

Organophosphates

A

AChE Inhibitor

43
Q

Atropine

A

Muscarinic Receptor Antagonist

aNeuro Exam I- Lindsey's (26 decks)

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