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aNeuro Exam I- Lindsey's > CNS Pharm > Flashcards

CNS Pharm Flashcards

1
Q

What is the NT pathophys of Alzheimer’s disease?

A

decreased ACh-M

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2
Q

What is the 1a pharm approach in Alzheimer’s disease?

A

increase ACh activity

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3
Q

What is the NT pathophys of acute/chronic pain?

A

abnormal PG, ion channels, 5HT, glutamate

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4
Q

What is the NT pathophys of Parkinson’s disease?

A

decreased striatal DA release (leading to increased ACh and increased GABA inhibition)

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5
Q

This is due to decreased striatal DA release (leading to increased ACh and increased GABA inhibition).

A

Parkinson’s disease

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6
Q

This is caused by abnormal PG, ion channels, 5HT, glutamate.

A

acute/chronic pain

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7
Q

This is caused by decreased ACh-M.

A

Alzheimer’s disease

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8
Q

What is the NT pathophys of seizure disorders?

A

abnormal VSSC-VSCC, decreased GABA and/or increased glutamate

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9
Q

This is caused by abnormal VSSC-VSCC, decreased GABA and/or increased glutamate.

A

seizure disorders

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10
Q

What is the 1a pharm approach in Parkinson’s disease?

A

increased DA activity

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11
Q

What is the 1a pharm approach in acute/chronic pain?

A

increase ENK activity, increase NE/5HT, decrease PG formation

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12
Q

What is the 1a pharm approach in seizure disorder?

A

increase GABA activity, block VSSC and VSCC

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13
Q

What is the 1a pharm approach in psychoses?

A

block D2 and 5HT2a receptors

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14
Q

What is the 1a pharm approach in depression?

A

increase synaptic levels of 5HT, NE, and DA

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15
Q

What is the 1a pharm approach in mania?

A

modulate NT activity, block VSSC-VSCC

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16
Q

What is the 1a pharm approach in anxiety?

A

enhance 5HT and GABA

17
Q

What is the 1a pharm approach in ADHD?

A

increase DA-NE activity

18
Q

What is the 1a pharm approach in insomnia?

A

increase GABA, decrease ACh and histamine

19
Q

What is the 1a pharm approach in general anethesia?

A

increase GABA, decrease NMDA-R function

20
Q

What is the NT pathophys of ADHD?

A

deficient DA-NE

21
Q

What is the NT pathophys of insomnia?

A

deficient GABA

22
Q

What is the NT pathophys of psychoses?

A

increased limbic DA with decreased PFC DA

23
Q

What is the NT pathophys of depression?

A

decreased 5HT-NE or decreased BDNF

24
Q

What is the NT pathophys of mania?

A

increased NE-DA activity

25
Q

What is the NT pathophys of anxiety?

A

decreased 5HT-GABA or increased NE overstimulates the amygada

aNeuro Exam I- Lindsey's (26 decks)

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