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Microbiology > Rickettsia, Chlamydia > Flashcards

Rickettsia, Chlamydia Flashcards

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Biology 101 flashcards
1
Q

Rickettsia and Chlamydia are gram __ bacteria

A

(-)

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2
Q

Rickettsia are transmitted by:

A

arthropod vectors (like mice)

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3
Q

What are the symptoms of Rickettsia?

A

local damage to blood v.v., inflammation (vasculitis), extravasated RBC’s

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4
Q

R. Rickettsia, after engulfment:

A

degrades the phagosome (with phospholipase A)

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5
Q

R. Coxiella, after engulfment:

A

remains in phagolysosome (likes acidic environment)

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6
Q

R. Ehrlichia, after engulfment:

A

remains in vacuole (phagosome), like TB

*doesn’t fuse with lysosome

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7
Q

Rocky Mountain Spotted Fever is a __-borne infection.

A

tick

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8
Q

For intracellular diseases, what drugs do we use?

A

Tetracycline and Chloramphenicol

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9
Q

What are the diagnosis methods for Rocky Mountain Spotted Fever?

A

MIF, DIF, and PCR

first two are antibody tests

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10
Q

Weil-Felix Test with Protease OX19 is associated with:

A

R. Rickettsia (it was a form of identifying the disease using WW2) *clumping = +

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11
Q

Number 1 bacterial STD?

A

Chlamydia

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12
Q

Number 1 microbial STD?

A

HPV

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13
Q

Rickettsia has tropism for:

A

vascular endothelial cells

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14
Q

Chlamydia has tropism for:

A

columnar epithelial cells lining mucous membranes

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15
Q

Chlamydia is ___, which means it has two forms.

A

dimorphic

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16
Q

Both Rickettsia and Chlamydia are obligate:

A

intracellular parasites

17
Q

Growth of Chlamydia is inhibited by what drugs?

A

Tetracylines and Erythromycin

Quinolones

18
Q

The infectious particle of Chlamydia is called the:

A

elementary body

19
Q

The important particle in Chlamydia for reproduction is called:

A

reticular body

20
Q

How does chlamydia avoid being killed by enzymes and lysosomes?

A

Because the phagocytic vesicle inhibits fusion with the lysosome
* Chlamydia can be killed if they are coated with antibodies; if they are, then the vesicle fuses with the lysosome so the lysosomal enzymes kill it

21
Q

Discuss the growth cycle of C. trachomatis.

A

Elementary body is engulfed by columnar epithelial cell. Then, the elementary body divides a bunch and becomes reticulate bodies. The vesicle containing the EB and RB’s exit the cell via reverse endocytosis and go on to infect other cells.

22
Q

Extracellular survival is a function of what form of chlamydia?

A

Elementary body (infectious particle)

23
Q

What allows us to see inclusion bodies?

A

Iodine

24
Q

What are the two types of antigens for Chlamydia?

A

Group and Specific antigens

25
Q

Discuss group vs specific antigens.

A 
Group = shared by all (heat stable, lipopolysaccharides)
Specific = outer membrane proteins
26
Q

List some general things about “Clam”ydia.

A

Trick: CLAMS have two shells!

  • Chlamydia has two antibody types (group & specific)
  • Chlamydia is dimorphic (two forms - reticular body and elementary body)
  • We have two eyes - Chlamydia can cause eye problem s (specifically Trachoma)
27
Q

One of the leading causes of blindness is caused by Chlamydia - what is it?

A

Ocular Trachomatis

28
Q

Serovars A, B, Ba, and C infect:

A

conjunctiva (primarily)

29
Q

Serovars D-K infect:

A

urogenital tract (like the DicK)

30
Q

Serovars L1, L2, L2a, L3 infect:

A

Inguinal lymph nodes (can cause LGV)

31
Q

Ancient eye disease?

A

Trachoma

32
Q

50% of GC patients are co-infected with:

A

Chlamydia Trachomatis

33
Q

What is lymphogranuloma venereum (LGV)?

A
  • STD characterized by suppurative inguinal adenitis
  • Regional lymph nodes are enlarged and painful
  • Can lead to elephantiasis of penis or vulva
34
Q

Treatment for LGV?

A

Cipro- (quinolones), Macrolides, Tetra-, Sulfonamides, Erythromycin

Microbiology (16 decks)

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