Herpesviruses

Question 1

HHV 8 stands for:

Answer 1

Kaposi’s sarcoma

Question 2

HHV 3 stands for:

Answer 2

Varicella Zoster Virus

Question 3

What herpesvirus causes chickenpox and shingles?

Answer 3

VZV

Question 4

What herpesvirus causes mononucleosis?

Answer 4

EBV

*also causes Burkitt’s Lymphoma and Nasopharyngeal carcinoma

Question 5

Herpes means:

Answer 5

creep or crawl

Question 6

What are the most common viruses found in humans?

Answer 6

herpesvirus

Question 7

TRUE OR FALSE:

Infection by herpesvirus lasts in body for life.

Answer 7

True

Question 8

herpesviruses establish a ___ ___ at a specific site in an immunocompromised host.

Answer 8

latent stage

Question 9

Space where proteins that assist in viral replication hang out:

Answer 9

Tegument

Question 10

List 6 qualities that herpesviruses share.

Answer 10

• Large viruses (bigger than HIV)
• Enveloped
• Icos
• dsDNA
• Pleomorphic
• Tegument

Question 11

How can enveloped viruses exit cells?

Answer 11

1) Budding (ex/ HIV)

2) Reverse endocytosis (ex/ Herpes)

Question 12

Discuss some CMV characteristics

Answer 12

C.M.V.

• Congenital (most common viral congenital infection)
• Macrophages (and lymphocytes) = cells where it hides
• Mono-like symptoms (20% of mono cases)
• Vertically transmitted - mom->child; also through sex and breastfeeding

Question 13

Discuss some EBV characteristics

Answer 13

E.B.V (Ebstein-Barr)

• B cells infected, associated with Burkett’s Lymphoma (and nasopharyngeal carcinoma)
• Barr “kissed” a lot of girls in “high school”, gave them “mono”
• B cells make a lot of antibodies (IgM), which can be detected in blood via heterphile Ab test
• Spleen can become inflamed bc of T cell response

Question 14

Mono symptoms in EBV are caused by:

Answer 14

aggressive T cell response to the hyper-proliferation and infection of B cells

Question 15

EBV remains latent in __ and __ for the rest of a person’s life.

Answer 15

throat and blood

Question 16

If you have AIDS and get infected with EBV, you would show signs of:

Answer 16

hairy leukoplakia on tongue

Question 17

Leukopenia = ?
Leukocytosis = ?

Answer 17

Leukopenia = in CMV patients
Leukocytosis = in EBV patients

Question 18

Kaposi’s sarcoma is associated with what herpes virus?

Answer 18

kAposit’s sarcoma:

• HHV 8
• AIDS patients
• inActivates Rb
• HIV tAt protein contributes to development of KS

Question 19

Herpes virus associated with childhood rash:

Answer 19

HHV 6 (and 7 too!)
*roseola, Sixth disease