Herpesviruses Flashcards
HHV 8 stands for:
Kaposi’s sarcoma
HHV 3 stands for:
Varicella Zoster Virus
What herpesvirus causes chickenpox and shingles?
VZV
What herpesvirus causes mononucleosis?
EBV
*also causes Burkitt’s Lymphoma and Nasopharyngeal carcinoma
Herpes means:
creep or crawl
What are the most common viruses found in humans?
herpesvirus
TRUE OR FALSE:
Infection by herpesvirus lasts in body for life.
True
herpesviruses establish a ___ ___ at a specific site in an immunocompromised host.
latent stage
Space where proteins that assist in viral replication hang out:
Tegument
List 6 qualities that herpesviruses share.
- Large viruses (bigger than HIV)
- Enveloped
- Icos
- dsDNA
- Pleomorphic
- Tegument
How can enveloped viruses exit cells?
1) Budding (ex/ HIV)
2) Reverse endocytosis (ex/ Herpes)
Discuss some CMV characteristics
C.M.V.
- Congenital (most common viral congenital infection)
- Macrophages (and lymphocytes) = cells where it hides
- Mono-like symptoms (20% of mono cases)
- Vertically transmitted - mom->child; also through sex and breastfeeding
Discuss some EBV characteristics
E.B.V (Ebstein-Barr)
- B cells infected, associated with Burkett’s Lymphoma (and nasopharyngeal carcinoma)
- Barr “kissed” a lot of girls in “high school”, gave them “mono”
- B cells make a lot of antibodies (IgM), which can be detected in blood via heterphile Ab test
- Spleen can become inflamed bc of T cell response
Mono symptoms in EBV are caused by:
aggressive T cell response to the hyper-proliferation and infection of B cells
EBV remains latent in __ and __ for the rest of a person’s life.
throat and blood
If you have AIDS and get infected with EBV, you would show signs of:
hairy leukoplakia on tongue
Leukopenia = ? Leukocytosis = ?
Leukopenia = in CMV patients Leukocytosis = in EBV patients
Kaposi’s sarcoma is associated with what herpes virus?
kAposit’s sarcoma:
- HHV 8
- AIDS patients
- inActivates Rb
- HIV tAt protein contributes to development of KS
Herpes virus associated with childhood rash:
HHV 6 (and 7 too!) *roseola, Sixth disease
