Richardson - Lymphoid Tissue Flashcards
Function of lymphoid tissues
Protect body from foreign substances and organisms
Distinguish self from non-self
Remove infected, damaged, or cancerous cells
Molecules that bind to antibodies or the T cell receptors
(Antibodies bind small regions of large molecules)
(T cell receptors bind small peptides processed from larger proteins)
Antigen
The N terminal region of heavy and light chains in antibodies is ____
Highly variable
Membrane bound antibodies have a _______ domain at the C terminal
Transmembrane
Form: membrane and secreted pentamer
Function: B cell antigen receptor
IgM
Form: membrane
Function: B cell antigen receptor:
IgD
Form: secreted, major immunoglobulin found in serum
Function: phagocytosis, Neonatal immunity
IgG
Form: secreted, binds to receptors on mast cells
Function: allergic reactions, parasites
IgE
Form: secreted Dimer
Function: mucosal immunity
IgA
Membrane bound antibodies
• Recognize epitopes on a variety of
extracellular macromolecules
B lymphocytes
• T cell receptor (TCR)
• Recognizes small peptides on the surface
of antigen presenting cells or infected cells
T Lymphocytes
Initial recognition and processing of antigens, done by dendritic cells, macrophages, and neutrophils
Innate immunity
Immune response and effector function
Lymphocytes
b cells - humoral
T cells- cell mediated
Plasma cells
Adaptive immunity
Part of adaptive immunity
Function to produce large quantities of antibodies
Plasma cells
Part of adaptive immunity.
Recoginzes antigens inside cells that are presented to the TCR
T Cells - cell mediated immunity
Part of adaptive immunity
Recognizes antigens outside the cell
B cells - humoral immunity
Neutrophils, macrophages, and langerhans cells are all part of the -_____- immmune system
Innate
Immature T cells migrate to _____ for further maturation
Thymus
Where does the negative selection for T cells that recognize self too strongly occur? (This prevents autoimmune disease)
Thymus
Filter for the lymph
Lymph nodes
Filter for the blood
Removal of aged red blood cells
Spleen
• Located throughout the body along lymph vessels • Filter for the lymph • Monitors for foreign antigens in tissues • Adaptive immune responses to lymph- borne antigens initiated
Lymph nodes
Lymphocytes enter lymph nodes from blood through
High endothelial venules (HEV)
Lymphocytes leave lymph nodes via
Efferent lymphatic vessels
Lymphocytes enter blood circulation through
Lymphatic ducts
High endothelial venules are found in secondary lymphoid tissues except___
Spleen
Where is mucosa -associated Lymphoid tissue (MALT) found?
In lamina propria underlying the mucosal epithelium of tissues w openings to external environment
GI tract
Respiratory tract
Reproductive tract
The T cell receptors bind ____
Small peptides processed from larger proteins
Immunoglobulin isotypes that are found in membranes
IgM
IgD
Pentamer immunoglobulin isotype
IgM
Major functions for lymph nodes
Filter lymph
Phagocytosis of bacteria / foreign substances from lymph
After entering the lymph nodes, B cells congregate on _______ of lymph nodes’ outer cortex
Lymphatic nodules
T cells congregate _____ the lymphatic nodules in the deep cortical or paracortical regions
Below
Lymph nodes are the location of _____ and _____ of B cells which gives rise to plasma cells and memory B cells
Antigenic recognition and antigenic activation
Circulating lymphocytes recognize __________ on high endothelial cells to know to enter lymph nodes from the blood
Lymphocyte homing receptors
In spleen; white pulp contains ?
B and T lymphocytes
In spleen; red pulp contains __
RBC’s, macrophages, and other blood cells
Ciliated pseudostratified columnar
epithelium, but can also have stratified squamous epithelium
• No crypts
Pharyngeal tonsil
Lateral walls of the oral pharynx
• Stratified squamous epithelium
• Multiple crypts
Palatine tonsil
Large amounts of ____ are secreted by plasma cells and subsequently transported across the epithelium into the lumen of the tissue in Mucosa-associated lymphoid tissue (MALT), which is found in lamina propria
IgA
Antibodies bind __
Small regions of large molecules
Immunoglobulin isotype that binds to mast cells to release histamine
IgE
Main function of thymus gland
Produce a diverse group of T cells that can respond to antigens
