Green - Smooth Muscle Flashcards
Calcium binding protein that activates MLCK
Calmodulin
IP3
Formed from PIP2 by Phopholipase C
Signaling molecule in smooth muscle contraction and relaxation
Found in tonic smooth muscle contractions where long-term tension is generated under conditions of low calcium and ATP concentrations
Latch State
In multi-unit smooth muscle, the cells are not connected _____
Electrically
Contractile fibers not arranged in sarcomeres
Contraction alters dimensions of organs
Contractions last much longer than in skeletal muscle
Smooth muscle
Actin thin filaments in smooth muscle cells contain tropomyosin but no ?:
Troponin
Myosin isoform is different in smooth muscle than that in skeletal muscle in that it has ?
Slower ATPase activity
Sustained smooth muscle contraction requires what ?
Extracellular calcium
Calcium enters the cell and binds to calmodulin. The calmodulin then activates _______ which phosphorylates regulatory light chains of myosin
Myosin light chain kinase
Smooth muscle contraction is _____- regulated
Thick filament
(Skeletal muscle is thin filament regulated_
Phasic contractions
Contracts rhythmically or intermittently
Tonic contractions
Contracts continuously