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AB 4th Year Rheum + Ortho > Rheumatology - Vasculitis > Flashcards

Rheumatology - Vasculitis Flashcards

1
Q

what are the medium vessel vasculitis?

A

kawasaki

polyarteritis nodosum

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2
Q

what are the large vessel vasculitis?

A

GCA

takayasu

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3
Q

what are the small vessel ANCA +ve vasculitis?

A

GPA (wegner’s)
MPA
eGPA (churg strauss)

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4
Q

what are the small vessel ANCA -ve vasculitis?

A

henoch schonlein
goodpasture’s
behcet’s
cryoglobulinaemia

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5
Q

what is GPA?

A

small vessel ANCA +ve vasculitis

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6
Q

what is the pathology in GPA?

A

granulomatous inflam in resp tract and small vessels

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7
Q

what is the triad of features in GPA?

A

upper RT
lower RT
glomerulonephritis

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8
Q

features of GPA?

A 
sinusitis
nasal crusting 
saddle shaped node
haemoptysis
fever
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9
Q

what type of glomerulonephritis do vasculitis get? features, Ix and management?

A

rapidly progressive

NEPHRITIC

fever, wt loss, haemoptysis

biopsy and urinalysis

steroids, cyclophosphamide and plasma exchange

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10
Q

Ix in GPA?

A

CXR
urinalysis
ESR, PV, CRP, FBC, U+Es
ANCA/cANCA

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11
Q

Tx for GPA?

A

steroids (can use topical for nasal disease)

cyclophosphamide

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12
Q

what is eGPA?

A

small vessel ANCA +ve vasculitis

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13
Q

what is the triad of pathology behind eGPA?

A

eosinophilia
granulomas
vasculitis

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14
Q

features of eGPA?

A

late onset asthma
rhinitis
purpura
mononeuritis multiplex

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15
Q

what is mononeuritis multiplex?

A

painful assymetrical peripheral neurpathy

affects 2 seperate nerve areas

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16
Q

Ix for eGPA?

A 
ANCA
pANCA
ESR, PV, CRP, FBC, U+E
urinalysis
CXR
eosinophils
echo
biopsy affected area
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17
Q

Tx for eGPA?

A

steroids

cyclophosphamide

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18
Q

what is microscopic polyangitis?

A

small vessel ANCA +ve vasculitis

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19
Q

what is nephritic syndrome a triad of?

A

AKI (oliguria)
HT/oedema
urinary sediment

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20
Q

features of microscopic polyangitis?

A

nephritic syndrome (GN)
haemoptysis
purpura

21
Q

Ix for microscopic polyangitis?

A 
ANCA
pANCA
ESR, PV, CRP, FBC, U+Es
urinalysis
CXR
22
Q

Tx for microscopic polyangitis?

A

steroids

cyclophosphamide

23
Q

what is henoch schonlein purpura?

A

small vessel ANCA -ve vasculitis

IgA mediated disorder with immune complex deposition

24
Q

who gets henoch schonlein purpura?

A

2-11yrs

Hx of URTI weeks ago

25
features of henoch schonlein purpura?
purpuric rash on lower limbs joint pain nephritic syndrome
26
what GN do those with henoch schonlein purpura get? treatment?
IgA ACE for BP control self limiting
27
Ix for henoch schonlein purpura?
urinalysis U+Es renal biopsy
28
what is polyarteritis nodosa?
medium vessel vasculitis | affects arteries at bifurcations -> aneurysms form
29
risk factors for polyarteritis nodosa?
male hep B 40-60yrs
30
features of polyarteritis nodosa?
wt loss athralgia high BP livedo reticularis
31
what is kawasaki disease?
medium vessel vasculitis
32
features of kawasaki disease?
``` fever >5days dry mouth/lips strawberry tongue maculopapular rash abdo pain ```
33
Ix for kawasaki disease? results?
FBC (raised WCC, platelets, anaemic) deranged LFTs raised PV/CRP/ESR echo
34
Tx for kawasaki disease?
steroids Igs NSAIDs
35
what are those with kawasaki disease at risk of?
coronary aneurysms
36
what is takayasu arteritis? pathology?
large vessel vasculitis | granulomas in large vessels (aorta and branches)
37
features of takayasu arteritis?
fever wt loss fatigue upper/lower limb claudication
38
what is found on examination in takayasu arteritis?
weak upper limb pulses increased BP unequal BP on either side murmurs
39
Ix for takayasu arteritis?
PV, ESR, CRP PET CT MR angio
40
what is goodpasture's? pathology?
ANCA -ve small vessel vasculitis anti GBM abs produced against Type IV collagen in he GBM
41
in goodpasture's, do they get nephritic/nephrotic syndrome?
nephritic
42
features of goodpasture's?
``` haemoptysis haematuria oedema HT fever ```
43
Ix for goodpasture's?
``` urinalysis U+Es, creatinine renal biopsy CXR anti GBM antibodies ```
44
Tx for goodpasture's?
steroids plasmaphoresis cyclophosphamide
45
what is behcet's syndrome?
ANCA -ve small vessel vasculitis
46
features of behcet's syndrome?
oral and genital ulcers skin involvement arthritis short duration of symptoms
47
what are cryoglobulins?
Igs that precipitate at low temperatures
48
features of cryoglobulinaemia?
rash GN (nephrotic - membranoproliferative) old people
49
what conditions can cause cryoglobulinaemia?
myeloma Hep C autoimmune conditions CLL

AB 4th Year Rheum + Ortho (17 decks)

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