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AB 4th Year Rheum + Ortho > Rheumatology - Autoimmune Systemic Conditions > Flashcards

Rheumatology - Autoimmune Systemic Conditions Flashcards

1
Q

what are the seropositive arthropathies?

A 
rheumatoid
lupus
scleroderma
vasculitis
sjogren's
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2
Q

what is the pathology of Sjogren’s?

A

lymphocytic infiltrate into exocrine glands (secrete substance into a duct)

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3
Q

features of Sjogren’s?

A 
dry eyes
dry mouth
athralgia
vaginal dryness
parotid gland swelling 
ILD
fatigue
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4
Q

Ix for Sjogren’s?

A

schirmer’s test

anti Ro/La

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5
Q

Tx for Sjogren’s?

A

lubricating eye drops
saliva replacement
pilocarpine (replace saliva)
hydroxychloroquine (for athralgia)

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6
Q

what are those with Sjogren’s at increased risk of?

A

lymphoma

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7
Q

what is the pathology behind systemic sclerosis (scleroderma)?

A

excessive collagen deposition in skin and organs

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8
Q

what are the two forms of systemic sclerosis (scleroderma)? where do they effect?

A

limited: face, hands, forearm and feet
organs involved later

diffuse: skin changes
early organ involvement

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9
Q

cutaneous features of systemic sclerosis (scleroderma)?

A 
raynaud's
oedema
indurative
atrophic (tight over fingers)
beaking of nose
telangectasia
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10
Q

what organ involvement can occur in systemic sclerosis (scleroderma)?

A

ILD
dysphagia
malabsorption
arthritis

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11
Q

Ix for systemic sclerosis (scleroderma)?

A 
anti centromere (limited)
anti Scl 70 (diffuse)
PFT
echo
renal function
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12
Q

Tx for systemic sclerosis (scleroderma)?

A

Raynaud’s - CCB
renal - ACE
GI - PPI
ILD - cyclophosphamide

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13
Q

risk factors for SLE?

A

black
FHx
female
child bearing age

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14
Q

what body systems can SLE affect?

A 
MSK
derm
renal
resp
neuro
GI
CVD
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15
Q

features of SLE?

A 
fever
fatigue
arthritis
malar rash 
raynaud's
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16
Q

pathology behind SLE?

A

type III hypersensitivy

immune complexes deposited in tissue over the body

17
Q

Ix for SLE?

A 
FBC
ESR, CRP, U+Es
urinalysis
ANA
anti dsDNA
anti Sm
CXR
echo
18
Q

what blood test is used to monitor disease activity in SLE?

A

low C3/4 when disease is active

anti dsDNA

19
Q

Tx for lupus?

A

hydroxychloroquine
Steroids
MTX (arthritis)
cyclophosphamide (organ disease)

20
Q

what are those with lupus at higher risk of?

A

CVD

21
Q

what are those with SLE advised about pregnancy?

A

wait 6 months from active disease before getting pregnant

anti Ro can cause heart block in babies

AB 4th Year Rheum + Ortho (17 decks)

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