Rheumatology Flashcards
1
Q
What is rheumatoid factor?
A
an IgM against IgG Fc
2
Q
What are tophi?
A
gout crystals + giant cells
3
Q
What is podagra?
A
big toe inflammaiton
4
Q
What is CREST syndrome?
A
C:calcinosis R: Raynaud's E: Esophageal dysmotility S: Sclerodactyly T: Telangiectasia
5
Q
What Ab is assoc with CREST?
A
anti-centromere ab
6
Q
What diseases have Raynaud’s syndrome
A
scleroderma
Takayasu’s
RA
SLE
7
Q
What platelet count do most types of vasculitides have?
A
low platelets
8
Q
Which vasculitis has a high platelet count?
A
Kawasaki disease
9
Q
Which vasculitis has normal platelet count?
A
Henoch-Schonlein Purpura
10
Q
What is osteoarthritis?
A
pain worse with activity
PIP/DIP joints
11
Q
What is rheumatoid arthritis?
A
pain worse in morning
MCP/PIP joints
12
Q
What is Still’s disease?
A
juvenile RA
13
Q
What is Pseudogout?
A
pyrophosphate crystals in knees and wrists
14
Q
What is gout?
A
urate crystals in big toe
neg birefringence
15
Q
What is myositis?
A
1 muscle hurts
16
Q
What is polymyositis?
A
> 1 muscle weak
17
Q
What is dermatomyositis?
A
myositis + rash
18
Q
What is fibromyalgia?
A
hurt all the time
11 trigger points
19
Q
What is polymyalgia rheumatica?
A
weak shoulders
temporal arteritis
20
Q
What is SLE (lupus)?
A
discoid rash
21
Q
What is scleroderma?
A
tight skin
fibrosis
22
Q
What is Takayasu Arteritis?
A
pulseless Asian women
aorta inflammation
23
Q
What is Polyarteritis Nodosa?
A
p-ANCA Ab
attacks gut/kidney
Hep B
24
Q
What is Wegner’s Granulomatosis?
A
c-ANCA Ab
attacks ENT, lungs, kidney
25
What is Goodpasture's?
anti-GBM ab
attacks lung/kidney
RPGN
26
What is Reiter's syndrome?
males that can't see, can't pee, can't climb a tree
27
What is Sjogren's syndrome?
females that have dry eyes/mouth
| RA
28
What is Behcet's syndrome?
oral and genital ulcers
| uveitis
29
What is Churg-Strauss?
asthma
eosinohils
multi-organ involvement
30
What is Felty's syndrome?
RA
leukopeia
spenomegaly
31
What is Kawasaki's Disease?
CRASH
C: conjunctivitis
R: rash (palms/soles)
A: aneurysm (coronary artery--> MI in kids)
S: strawberry tongue
H: hot (fever >102 for at least 3 days + cervical lymphadenopathy)
32
What is the complication of temporal ateritis?
blindness
33
What is another name for temporal arteritis?
giant cell arteritis
34
How do you diagnose temporal arteritis?
temporal artery biopsy
35
What is the rule of 60's for temporal arteritis?
age>60
ESR>60
60mg prednisone to tx
36
What condition is assoc with one muscle hurting?
myositis
37
What condition is assoc with several muscles hurting?
polymyositis
38
What condition is assoc with musle pain plus rash?
dermatomyositis
39
What condition is assoc with inflamed muscle insertions?
fibrositis
40
What condition causes pain of muscle and muscle insertion?
fibromyalgia
41
What condition is assoc with shoulder girdle hurting most?
polymyalgia rheumatica
42
What condition is assoc with visceral cancer?
dermatomyositis (colon cancer)
43
What condition is assoc with Rifampin, INH, Statins,Prednisone, and hypothyroidism?
myositis
44
What condition is treated with amitriptyline?
fibromyalgia
45
What condition is increased in temporal arteritis?
polymyalgia rheumatica
46
What condition is assoc with multiple trigger points?
fibromyalgia
47
What condition is assoc with muscle pain when moving?
fibrositis
48
What condition is assoc with heliotropic rash?
dermatomyositis
49
What condition is assoc with a throbbing temporal headache?
temporal arteritis
50
What drugs cause myositis?
rifampin
INH
statins
prednisone
51
What disease causes myositis?
hypothyroidism
52
What is the treatment for multiple sclerosis?
```
#1 steroids
#2 blocking immunoglobulins (TNF-beta)
#3 plasmapheresis
```
53
What structure does MS like to attack
medial longitudinal fasciculus--> internuclear opthalmoplegia
54
What is the diagnosis for a middle aged woman with optic neuritis (eye problem)?
multiple sclerosis
55
What is the equivalent disease to MS in children
metachromatic leukodystrophy
56
What vasculitis occurs 2 wks after a common cold?
Berger's
57
What disease presents as a smoking Jew with necrotizing vasculitis?
Buerger's
58
What disease has a family history of deafness and cataracts?
Alport's
59
What vasculitis has a strawberry tongue?
Kawasaki's
60
What vasculitis has fibrin split products?
DIC
61
What vasculitis presents 2 wks after E. coli gastroenteritis?
hemolytic uremic syndrome
62
What vasculitis presents with fever, thrombocytopenia, and neuro problems?
ITP
63
What vasculitis attacks midsize arteries (particularly in GI and kidney)?
polyarteritis nodosa
64
What vasculitis affects the sinuses, lung, and kidney
Wegner's Granulomatosis
65
What vasculitis has linear immunofluorescence on GBM with lung involvement?
Goodpasture's
66
What vasculitis has pulmonary infiltrates with eosinophilia?
Churg-Strauss
67
What glomerulonephritis occurs two weeks after a sore throat?
Post-Strep Glomerulonephritis
68
What vasculitis presents two wks after vaccination?
serum sickness
69
What disease leads to septic emboli?
subacute bacterial endocarditis
70
What is the only vasculitis with a normal platelet count?
HSP
71
What is the only vasculitis with a high platelet count?
Kawasaki's
72
What is the MCC of death in SLE?
renal failure
73
What protein is decreased in all vasculitides?
haptoglobin
74
What cellular response is seen in all vasculitides?
T cells and macrophages
75
What are the clues for Kawasaki?
mucositis
rash on palms and soles
cervical lymph nodes
fever>102 for >3days
76
What are the clues for TTP?
fever
thrombocytopenia
neurologic problems
77
What are the clues for polyarteritis nodosa?
midsized arteries (GI and renal)
associated with Hep B
p-ANCA
78
What are the clues for Churg-Strauss?
allergic vasculitis
79
What are the clues for SBE?
caused by strep viridens
80
What are the clues for MPGN I?
tram tracks with C3 nephritic factor in basement membrane
81
What are the clues for MPGN II?
tram tracks with low complement (dense deposit disease)
82
What are clues for CREST?
mildest form of scleroderma
| patchy involvement
83
What are the clues for scleroderma?
anti-scl70 Ab
| anti-sm muscle Ab
84
What are clues for progressive systemic sclerosis?
scleroderma with organ involvement
85
What are clues for rheumatoid arthritis?
symmetrical polyarteritis
| worse in morning
86
What are clues for juvenile rheumatoid arthritis?
arthritis with iridesis
87
What are clues for Felty's?
RA + leukopenia + splenomegaly
88
What are clues for Behcet's?
RA + GI ulcers
89
What are clues for Sjogren's?
RA + dry eyes, dry mouth
90
What is the vasculitis with GI bleeding, intussusception, and normal platelet count?
HSP
91
What is the vasculitis whose most common cause of sepsis?
DIC
92
What is the most common cause of renal failure in children?
HUS
93
What is the vasculitis with which Hep B is assoc with?
PAN
94
What vasculitis causes pulmonary infiltrate with eosinophilia?
Churg-Strauss
95
What vasculitis has xerophthalmia and xerostomia?
sjogren's
96
What is the most common cause of arthritis in a middle aged female?
rheumatoid arthritis
97
What is the only arthritis that attacks the synovium?
rheumatoid arthritis
