Rheumatology Flashcards
1
Q
what is a positive ANA titers? Signifiance?
A
2
Q
which diseases are associated with Anti-dsDNA?
A
3
Q
which antinuclear antibodies associated with Anti-Sm?
A
4
Q
which antinuclear antibodies associated with SsA (Ro)?
A
5
Q
which antinuclear antibodies associated with SSB (La)?
A
6
Q
which antinuclear antibodies associated with Anti-U1-RNP?
A
7
Q
which antinuclear antibodies associated with antihistone? which 4 drugs?
A
8
Q
which antinuclear antibodies associated with anticentromere?
A
9
Q
which antinuclear antibodies associated with Anti-RNA polymerase III?
A
10
Q
which antinuclear antibodies associated with Anti-Scl-70 (topoisomerase I)?
A
11
Q
which antinuclear antibodies associated with antisynthetase?
A
12
Q
antibodies specific for SLE?
A
Specific but not sensitive: Anti-dsDNA, ANti-Smith, anti ribosomal P protein
13
Q
signifiance of Anti-U1-RNP? Sensitivity and specficity?
A
14
Q
signifiance of antihistone antibody?
A
15
Q
significance of Anti-Scl-70 antibodies? clinical asociations? cross reactivity?
A
16
Q
significance of SSA and SSB antibodies?
A
17
Q
what happens if C-Anca positive, what other test can help you identify which disease?
A
18
Q
wat are the 3 pathways and their ultimate function?
A
19
Q
what are the causes of low complement levels?
A
20
Q
sensitivity and specificity of RF and anti-CCP? . associations?
A
21
Q
association of HLAB-27 markers?
A
22
Q
Association of HLA DR2, DR3, and DR4?
A
23
Q
Association of:
- HLA b5701
- HLA b-51
- HLA Dq2/Dq8
- HLA B5801
A
24
Q
what are the common indications for synovial fluid analysis?
A
25
describe the 5 types of synovial joint fluids, color, viscosity and disease associations?
26
gout vs CPPD on crystal analysis?
27
what are the 7 criteria to aid in the diagnosis of Marfan syndrome?
28
what are the Ehlers-Danlos syndrome criteria?
29
what are the classifications of Ehlers danlos syndrome?
30
what are the features of osteogenesis imperfectais?
31
what is the pseudoxanthoma elasticum?
32
what lab results are associated with more aggressive RA?
33
what is the hallmark of RA disease on signs and symptoms?
34
what are physical exam deformities in RA?
35
what are the radiographic findings in RA joint destruction?
36
what is palindromic rheumatism?
37
what are the poor prognostic indicators of RA?
38
what is the basic ACR/EULA classification criteria for RA?
39
when would you suspect cervical spine subluxation in RA?
40
if you suspect cervical spine subluxation in RA, what would you order?
41
what other symptoms outside of C2 subluxation/peripheral joints, does RA affect?
42
what are the extraarticular cardiac, lung, and renal manifestations of RA?
43
what are the vasculitis, nerves, and eye extraarticular manifestations of RA?
44
what is the skin and blood/lymphatics extraarticular manifestations of RA?
45
what is felty syndrome?
46
what are the category of drugs used to treat RA?
47
what is the general treatment strategy of RA ?
48
DMARDs used to treat RA - class, use, and side effects:
1. Methotrexate
2. Leflunomide
3. HCQ
4. sulfasalizine
5. Tofacitinib/upadacitinib
49
what are the principles of methotrexate for RA if they want to become pregnant?
50
what are the side effects of mTX?
51
what is important to know about methorexate and the lungs? findings?
52
what should you do before prescribing MTX?
53
side effects of leflunomide and pregnancy considerations?
54
what are the risk factors for hydroxychloroquine?
55
what is the use/side effects of sulfasalazine?
56
what are the important side effets to note for tofacitinib? cateogry?
57
what are the biological DMARDs, class, use, and side effects?
1. Infliximab/Adalimumab
2. Tocilizumab
3. Anakinra
4. Rituximab
5. Abatacept
58
what is the following names:
1. -XImab?
2. -ZUmab?
3. -Mumab?
59
Side effect of TNF-Alpha inhibitors?
60
who should you avoid live attenuated vaccines in RA?
61
benefit/pathophys/side effect of azathioprine?
62
what are the side effects/pathophys of cyclosporine and cylophosphamide?
63
what are the perioperative rhem considerations for DMARDS, biologics,and SLE?
64
what are the guidelines for managing pregnant women with active inflammatory arthritis?
1. HCQ/SSZ?
2. TNF?
3. Steroids?
4. Azathiopurine/Cyclosporine
5. Antimetabolites?
65
what is the presentation of lupus arthritis?
66
how would you classify lupus rashes?
67
what are the lung and heart manifestations of lupus?
68
when would you suspect lupus nephritis on labs?
69
treatment of SLE renal disease?
70
what are the blood manifestations of lupus?
71
dx criteira for lupus?
72
how would you interpret the autoantibodies for SLE?
73
what is the prognostic factors for SLE?
74
what are the 4 drugs APPROVED for the treatment of SLE?
75
what are general recommendations for all patients with SLE?
76
what drug should all patients with SLE be put on? benefits?
77
the general strategy to treat mild, moderate, and severe lupus?
78
Relationship of SLE and pregnancy?
79
describe neonatal lupus?
80
how to distinguish lupus flare with renal involvement from pre-eclampsia?
81
dx and highest risk factors for drug-induced lupus?
82
treatment of drug-induced lupus?
83
what are the 4 major spondyloarthritidies?
84
what are the common features of seronegative spondyloarthritides?
85
what are some big similarities and differences between seronegative spondyloarthritiides vs seropositive (general)?
86
what is the common presentation of ankylosing spondylitis?
87
what are the extraarticular manifestations of ankylosing spondylitis?
88
what is mechanical back pain vs inflammatory back pain?
89
what test can you use to see if the patient has inflammatory back pain?
90
what radiographic and serological findings will you see in AS?
91
what is the treatment of AS?
92
Presentation of DISH?
93
classic findings of DISH and tx?
94
presentation of reactive arthritis?
95
what are the extra-articular manifestations of reactive arthritis?
96
when should you suspect reactive arthritis?
97
treatment of reactive arthritis?
98
what are the two forms of IBD-associated arhtropathy?
99
what is the extra-articular manifestations of IBD and therapy for IBD?
100
what are the presentations of joint involvement with psoriatic arthritis?
101
describe radiographic differences between psoriatic arthritis vs inflammatory OA?
102
treatment of psoriatic arthritis?
103
what is the classic presentation of joint damage in oA?
104
Describe OA of the hands?
105
describe the joints affected by rheumatological diseases?
106
what is the diagnostic criteria for hand OA?
107
what is the classic presentation of hip OA?
108
what is the diagnostic criteria for hip OA?
109
what is the classic presentation of Knee OA?
110
when should you suspect knee OA?
111
Treatment for knee OA?
112
treatment for hand OA?
113
treatment for hip OA?
114
what are the common forms of crystalline arthritis?
115
basics of gout?
116
risk factors for gouty arthritis?
117
how would you determine the etiology of patient's gout in terms of labs?
118
what are the phases of gout?
119
what is the presentation of acute gouty arthritis?
120
how do you diagnose a gout flare?
121
what is the treatment of gout flares?
122
what is the chronic treatment of gout genearlly?
123
when do you initiate urate-lowering therapy in chronic gout?
124
what is the initial drug choice for chronic gout?
125
what is the side effects and key considerations for allopurinol?
126
what alternative is there to allopurinol if not tolerated? Benefits compared to allopurinol?
127
what are the 2 types of uricase?
128
what are the uricosuric agents?
probenecid and lesinurad
129
when should you avoid probenecid?
130
what are the interactions of urate lowering therapy with aspirin?
131
what is the ddx of acute monoarticular joint swelling?
132
what are radiographic findings suggestive of gout?
133
what is the goal of ULT and what should you also prescribe?
134
what is CPPD?
135
when you see CPPD in patient\<50 years of age, what predisposing conditions should you consider? what should you check?
136
what joints does CPPD arthropathy affect?
137
138
how do you diagnose CPPD?
139
how do you manage CPPD acutely?
140
what is hydroxypapatite arthropathy?
141
when should you think hydroxyapatite arthropathy?
142
diagnosis and treatment of hydroxyapatite arthropathy?
143
what is the presentation and basic dx of septic arthritis?
144
septic joint most common organism, port of entry, bacteria?
145
most common bacteria, port of entry in young adults?
146
most common bacteria, port of entry in human bites?
147
most common bacteria, port of entry in animal bites?
148
most common bacteria, port of entry in sickle cell patients?
149
most common bacteria, port of entry in patients with prosthetic joints?
150
most common bacteria, port of entry in IDU?
151
most common bacteria, port of entry in patients with mulitple comorbidities?
152
most common bacteria, port of entry in immunosuppresed patients?
153
most common bacteria, port of entry in fisherman, aquarium hobbyist?
154
what are predisposing risk factors for gonococcal arthritis?
155
what should you do if disseminated gonorrhea (micro)?
156
how do prosthetic joint infections present and treatment?
157
Presentation of whipple disease?
158
diagnosis and treatment of whipple disease?
159
what is the presentation of TB arthritis?
160
how would you diagnose TB arthritis? Tx?
161
what is the presentation of parvovirus b19 synovitis? diagnosis and tx?
162
Other than parvovirus b19, what are the other causes of nonbacterial synovitis?
163
when should you suspect acute rheumatic fever joint infection?
164
Jones criteria and tx of acute rheumatic fever?
165
describe poststreptococcal reactive arthritis?
166
Describe the basics of chikungunya? Tx?
167
what shows false positive lyme ELISA serology?
168
how do you treat lyme arthritis?
169
what is the presentation of adult-onset still disease?
170
what are the lab abnormalities associated with adult-onset still disease?
171
what is the treatment of adult-onset still disease?
172
what is the presentation and radiographic findings of hemochromatosis arthritis?
173
what is the treatment of hemochromatosis?
174
what are the 2 proposed mechanisms of neuropathic joints? MCC
175
what joint findings and treatment of neuropathic joint?
176
when should you suspect hypertrophic pulmonary osteoarthropathy?
177
describe the basics of primary raynaud phenomenon?
178
describes the basics of secondary raynaud phenomenon?
179
common drugs that may exacerbate raynaud phenomenon? what should you avoid?
180
what is the pathophysiology of raynaud phenomenon?
181
what physical exam findings suggest the secondary Raynaud phenomenon?
182
what is the treatment of raynaud phenomenon?
183
what ddx can be similar to raynaud phenomenon?
184
what is the sensitivity and specificity of Anti-U1-RNP?
185
basics, presentaiton, tx of Ig4-related disease?
186
what is the diagnostic criteria of antiphospholipid syndrome?
187
what other findings not included in the diagnostic criteria can be seen in APS? prognostic factors?
188
what is the acute and chronic treatment of APS?
189
what is the pathophysiology of sjogren syndrome?
190
classic presentation of sjogren syndrome?
191
how would you dianose sjogren syndrome?
192
what is the significant risk for patients with sjogren syndrome?
193
what is the treatment for sjogren syndrome?
194
what is the autoantibodies and prognostic factors associated with diffuse cutaenous systemic sclerosis?
195
what are the key features of limited cutaneous SSc?
196
what is the lung problem associated with limited cutaenous Ssc? Autoantibody?
197
what are the kidney complications with scleorderma? tx?
198
how would you distingusih eosinophilic fasciitis from systemic sclerosis?
199
compare and contrast PM vs DM?
200
distinguishing features of myositis vs PMR vs Fibromyalgia?
201
what are the skin findings for Dermatomyositis?
202
what is antisynthetase syndrome?
203
how do you diagnose PM and DM?
204
what are the myositis specific antibodies? (5)
205
what important long term complication is associated with PM/DM?
206
how do you treat PM/DM?
207
what do you need to do for anyone who is on long term glucocorticoids?
208
when do you suspect inclusion body myositis? Dx and tx?
209
what drugs are associated with drug-induced myopahty/
210
what are the 2 ways glucocorticoid myopathy typically presents?
211
what is fibromyalgia? Dx criteria?
212
what is the treatment for Fibromyaglia?
213
what is CRPS and the 2 types?
214
what are the 2 pathophys MCC of vasculitis?
215
when should you consider vasculitis on phyiscal exam/symptoms?
216
what labs would you suggest vasculitis?
217
how do you confirm dx of vasculitis?
218
basics of GCA presentation and dx?
219
management of GCA?
220
when should you think PMR?
221
treatment of PMR?
222
presentation of takayasu arterities?
223
diagnose of takayasu arteritis?
224
what are the common aortitis associations?
225
what are the common medial/small artery vasculitis?
226
what does PAN not cause?
pulmonary arteries and glomerulonephritis
227
pathophysiology of PAN?
228
when should you suspect PAN?
229
how would you diagnose PAN?
230
treamtent of PAN?
231
when to suspect EGPA, labs and tx?
232
when to suspect GPA?
233
how would you confirm dx of GPA?
234
treamtent of GPA?
235
basics, tx, labs of MPA?
236
what is the classic skin manifestation of hypersensitivty vasculitis?
237
what are the common causes of hypersensitivity vasculitis?
238
treatment of hypersensitivity vasculitis?
239
what are the organs affected in IgA vasculitis? Pathophys?
240
confirmation of dx and treatment of IgA vasculitis?
241
what are cryoglobulins?
242
what are the 3 types of cryoglobulins?
243
what is the presentation of hep C and mixed cryoglobulinemia?
244
what is the work up for suspected mixed cryoglobulinemia?
245
what is the tx of hep C vasculitis?
246
what is anti-GBM disease? Dx and tx?
247
what ar ethe pulmonary-renal syndromes?
248
how to distinguish ulcers from Behcet vs lupus?
249
what is the criteria for behcet disease?
250
treatment for behcet disease?
251
what is relapsing polychondirits?
252
what is MAGIC syndrome?
253
what rheumatocal issues are associated with malignancy? (5)
254
what rheumatoligcal conditions are associated with DM2?
255
what is pagest disease of the bone associated with?
256
what is the dx and therapy for amyloidosis?
257
