Rheumatology Flashcards
what is a positive ANA titers? Signifiance?
which diseases are associated with Anti-dsDNA?
which antinuclear antibodies associated with Anti-Sm?
which antinuclear antibodies associated with SsA (Ro)?
which antinuclear antibodies associated with SSB (La)?
which antinuclear antibodies associated with Anti-U1-RNP?
which antinuclear antibodies associated with antihistone? which 4 drugs?
which antinuclear antibodies associated with anticentromere?
which antinuclear antibodies associated with Anti-RNA polymerase III?
which antinuclear antibodies associated with Anti-Scl-70 (topoisomerase I)?
which antinuclear antibodies associated with antisynthetase?
antibodies specific for SLE?
Specific but not sensitive: Anti-dsDNA, ANti-Smith, anti ribosomal P protein
signifiance of Anti-U1-RNP? Sensitivity and specficity?
signifiance of antihistone antibody?
significance of Anti-Scl-70 antibodies? clinical asociations? cross reactivity?
significance of SSA and SSB antibodies?
what happens if C-Anca positive, what other test can help you identify which disease?
wat are the 3 pathways and their ultimate function?
what are the causes of low complement levels?
sensitivity and specificity of RF and anti-CCP? . associations?
association of HLAB-27 markers?
Association of HLA DR2, DR3, and DR4?
Association of:
- HLA b5701
- HLA b-51
- HLA Dq2/Dq8
- HLA B5801
what are the common indications for synovial fluid analysis?
describe the 5 types of synovial joint fluids, color, viscosity and disease associations?
gout vs CPPD on crystal analysis?
what are the 7 criteria to aid in the diagnosis of Marfan syndrome?
what are the Ehlers-Danlos syndrome criteria?
what are the classifications of Ehlers danlos syndrome?
what are the features of osteogenesis imperfectais?
what is the pseudoxanthoma elasticum?
what lab results are associated with more aggressive RA?
what is the hallmark of RA disease on signs and symptoms?
what are physical exam deformities in RA?
what are the radiographic findings in RA joint destruction?
what is palindromic rheumatism?
what are the poor prognostic indicators of RA?
what is the basic ACR/EULA classification criteria for RA?
when would you suspect cervical spine subluxation in RA?
if you suspect cervical spine subluxation in RA, what would you order?
what other symptoms outside of C2 subluxation/peripheral joints, does RA affect?
what are the extraarticular cardiac, lung, and renal manifestations of RA?
what are the vasculitis, nerves, and eye extraarticular manifestations of RA?
what is the skin and blood/lymphatics extraarticular manifestations of RA?
what is felty syndrome?
what are the category of drugs used to treat RA?
what is the general treatment strategy of RA ?
DMARDs used to treat RA - class, use, and side effects:
- Methotrexate
- Leflunomide
- HCQ
- sulfasalizine
- Tofacitinib/upadacitinib
what are the principles of methotrexate for RA if they want to become pregnant?
what are the side effects of mTX?
what is important to know about methorexate and the lungs? findings?
what should you do before prescribing MTX?
side effects of leflunomide and pregnancy considerations?
what are the risk factors for hydroxychloroquine?
what is the use/side effects of sulfasalazine?
what are the important side effets to note for tofacitinib? cateogry?
what are the biological DMARDs, class, use, and side effects?
- Infliximab/Adalimumab
- Tocilizumab
- Anakinra
- Rituximab
- Abatacept
what is the following names:
- -XImab?
- -ZUmab?
- -Mumab?
Side effect of TNF-Alpha inhibitors?
who should you avoid live attenuated vaccines in RA?
benefit/pathophys/side effect of azathioprine?
what are the side effects/pathophys of cyclosporine and cylophosphamide?
what are the perioperative rhem considerations for DMARDS, biologics,and SLE?
what are the guidelines for managing pregnant women with active inflammatory arthritis?
- HCQ/SSZ?
- TNF?
- Steroids?
- Azathiopurine/Cyclosporine
- Antimetabolites?
what is the presentation of lupus arthritis?
how would you classify lupus rashes?
what are the lung and heart manifestations of lupus?
when would you suspect lupus nephritis on labs?
treatment of SLE renal disease?
what are the blood manifestations of lupus?
dx criteira for lupus?
how would you interpret the autoantibodies for SLE?
what is the prognostic factors for SLE?
what are the 4 drugs APPROVED for the treatment of SLE?
what are general recommendations for all patients with SLE?
what drug should all patients with SLE be put on? benefits?
the general strategy to treat mild, moderate, and severe lupus?
Relationship of SLE and pregnancy?
describe neonatal lupus?
how to distinguish lupus flare with renal involvement from pre-eclampsia?
dx and highest risk factors for drug-induced lupus?
treatment of drug-induced lupus?
what are the 4 major spondyloarthritidies?
what are the common features of seronegative spondyloarthritides?
what are some big similarities and differences between seronegative spondyloarthritiides vs seropositive (general)?
what is the common presentation of ankylosing spondylitis?
what are the extraarticular manifestations of ankylosing spondylitis?
what is mechanical back pain vs inflammatory back pain?
what test can you use to see if the patient has inflammatory back pain?
what radiographic and serological findings will you see in AS?
what is the treatment of AS?
Presentation of DISH?
classic findings of DISH and tx?
presentation of reactive arthritis?
what are the extra-articular manifestations of reactive arthritis?
when should you suspect reactive arthritis?
treatment of reactive arthritis?
what are the two forms of IBD-associated arhtropathy?
what is the extra-articular manifestations of IBD and therapy for IBD?
what are the presentations of joint involvement with psoriatic arthritis?
describe radiographic differences between psoriatic arthritis vs inflammatory OA?
treatment of psoriatic arthritis?
what is the classic presentation of joint damage in oA?
Describe OA of the hands?
describe the joints affected by rheumatological diseases?
what is the diagnostic criteria for hand OA?
what is the classic presentation of hip OA?
what is the diagnostic criteria for hip OA?
what is the classic presentation of Knee OA?
when should you suspect knee OA?
Treatment for knee OA?
treatment for hand OA?
treatment for hip OA?
what are the common forms of crystalline arthritis?
basics of gout?
risk factors for gouty arthritis?
how would you determine the etiology of patient’s gout in terms of labs?
what are the phases of gout?
what is the presentation of acute gouty arthritis?
how do you diagnose a gout flare?
what is the treatment of gout flares?
what is the chronic treatment of gout genearlly?
when do you initiate urate-lowering therapy in chronic gout?
what is the initial drug choice for chronic gout?
what is the side effects and key considerations for allopurinol?
what alternative is there to allopurinol if not tolerated? Benefits compared to allopurinol?
what are the 2 types of uricase?
what are the uricosuric agents?
probenecid and lesinurad
when should you avoid probenecid?
what are the interactions of urate lowering therapy with aspirin?
what is the ddx of acute monoarticular joint swelling?
what are radiographic findings suggestive of gout?
what is the goal of ULT and what should you also prescribe?
what is CPPD?
when you see CPPD in patient<50 years of age, what predisposing conditions should you consider? what should you check?
what joints does CPPD arthropathy affect?
how do you diagnose CPPD?
how do you manage CPPD acutely?
what is hydroxypapatite arthropathy?
when should you think hydroxyapatite arthropathy?
diagnosis and treatment of hydroxyapatite arthropathy?
what is the presentation and basic dx of septic arthritis?
septic joint most common organism, port of entry, bacteria?
most common bacteria, port of entry in young adults?
most common bacteria, port of entry in human bites?
most common bacteria, port of entry in animal bites?
most common bacteria, port of entry in sickle cell patients?
most common bacteria, port of entry in patients with prosthetic joints?
most common bacteria, port of entry in IDU?
most common bacteria, port of entry in patients with mulitple comorbidities?
most common bacteria, port of entry in immunosuppresed patients?
most common bacteria, port of entry in fisherman, aquarium hobbyist?
what are predisposing risk factors for gonococcal arthritis?
what should you do if disseminated gonorrhea (micro)?
how do prosthetic joint infections present and treatment?
Presentation of whipple disease?
diagnosis and treatment of whipple disease?
what is the presentation of TB arthritis?
how would you diagnose TB arthritis? Tx?
what is the presentation of parvovirus b19 synovitis? diagnosis and tx?
Other than parvovirus b19, what are the other causes of nonbacterial synovitis?
when should you suspect acute rheumatic fever joint infection?
Jones criteria and tx of acute rheumatic fever?
describe poststreptococcal reactive arthritis?
Describe the basics of chikungunya? Tx?
what shows false positive lyme ELISA serology?
how do you treat lyme arthritis?
what is the presentation of adult-onset still disease?
what are the lab abnormalities associated with adult-onset still disease?
what is the treatment of adult-onset still disease?
what is the presentation and radiographic findings of hemochromatosis arthritis?
what is the treatment of hemochromatosis?
what are the 2 proposed mechanisms of neuropathic joints? MCC
what joint findings and treatment of neuropathic joint?
when should you suspect hypertrophic pulmonary osteoarthropathy?
describe the basics of primary raynaud phenomenon?
describes the basics of secondary raynaud phenomenon?
common drugs that may exacerbate raynaud phenomenon? what should you avoid?
what is the pathophysiology of raynaud phenomenon?
what physical exam findings suggest the secondary Raynaud phenomenon?
what is the treatment of raynaud phenomenon?
what ddx can be similar to raynaud phenomenon?
what is the sensitivity and specificity of Anti-U1-RNP?
basics, presentaiton, tx of Ig4-related disease?
what is the diagnostic criteria of antiphospholipid syndrome?
what other findings not included in the diagnostic criteria can be seen in APS? prognostic factors?
what is the acute and chronic treatment of APS?
what is the pathophysiology of sjogren syndrome?
classic presentation of sjogren syndrome?
how would you dianose sjogren syndrome?
what is the significant risk for patients with sjogren syndrome?
what is the treatment for sjogren syndrome?
what is the autoantibodies and prognostic factors associated with diffuse cutaenous systemic sclerosis?
what are the key features of limited cutaneous SSc?
what is the lung problem associated with limited cutaenous Ssc? Autoantibody?
what are the kidney complications with scleorderma? tx?
how would you distingusih eosinophilic fasciitis from systemic sclerosis?
compare and contrast PM vs DM?
distinguishing features of myositis vs PMR vs Fibromyalgia?
what are the skin findings for Dermatomyositis?
what is antisynthetase syndrome?
how do you diagnose PM and DM?
what are the myositis specific antibodies? (5)
what important long term complication is associated with PM/DM?
how do you treat PM/DM?
what do you need to do for anyone who is on long term glucocorticoids?
when do you suspect inclusion body myositis? Dx and tx?
what drugs are associated with drug-induced myopahty/
what are the 2 ways glucocorticoid myopathy typically presents?
what is fibromyalgia? Dx criteria?
what is the treatment for Fibromyaglia?
what is CRPS and the 2 types?
what are the 2 pathophys MCC of vasculitis?
when should you consider vasculitis on phyiscal exam/symptoms?
what labs would you suggest vasculitis?
how do you confirm dx of vasculitis?
basics of GCA presentation and dx?
management of GCA?
when should you think PMR?
treatment of PMR?
presentation of takayasu arterities?
diagnose of takayasu arteritis?
what are the common aortitis associations?
what are the common medial/small artery vasculitis?
what does PAN not cause?
pulmonary arteries and glomerulonephritis
pathophysiology of PAN?
when should you suspect PAN?
how would you diagnose PAN?
treamtent of PAN?
when to suspect EGPA, labs and tx?
when to suspect GPA?
how would you confirm dx of GPA?
treamtent of GPA?
basics, tx, labs of MPA?
what is the classic skin manifestation of hypersensitivty vasculitis?
what are the common causes of hypersensitivity vasculitis?
treatment of hypersensitivity vasculitis?
what are the organs affected in IgA vasculitis? Pathophys?
confirmation of dx and treatment of IgA vasculitis?
what are cryoglobulins?
what are the 3 types of cryoglobulins?
what is the presentation of hep C and mixed cryoglobulinemia?
what is the work up for suspected mixed cryoglobulinemia?
what is the tx of hep C vasculitis?
what is anti-GBM disease? Dx and tx?
what ar ethe pulmonary-renal syndromes?
how to distinguish ulcers from Behcet vs lupus?
what is the criteria for behcet disease?
treatment for behcet disease?
what is relapsing polychondirits?
what is MAGIC syndrome?
what rheumatocal issues are associated with malignancy? (5)
what rheumatoligcal conditions are associated with DM2?
what is pagest disease of the bone associated with?
what is the dx and therapy for amyloidosis?
