Rheumatoid Drugs Flashcards
1
Q
Methotrexate mechanism
A
- folate antagonist - binds to dihydrofolate reductase
- give orally or subcutaenous
2
Q
adverse effects of Methotrexate
A
- pneumonitis - pulmonary fibrosis
- hepatotoxocity
- myelosuppression
- rash/mouth ulcers
- leucopenia
- thrombocytopenia
- GI upset - nausea and diarrhoea
3
Q
what should be avoided with Methotrexate
A
- Avoid giving trimethoprim and co-trimoxazole as they are anti-folate antibiotics
- Additive folate depletion causes bone marrow aplasia
4
Q
is Methotrexate safe in pregnancy
A
no, teratogenic, stop males and females 3 months before conception
5
Q
what type of drug is Sulfasalazine
A
aminosalicylate
6
Q
mechanism of action of Sulfasalazine
A
unknown
7
Q
how is Sulfasalazine adminstered
A
orally
8
Q
adverse effects of Sulfasalazine
A
- •Temporary oligospermia
- •Severe depression
- •Thrombocytopenia
- •Hepatitis
- •Neutropenia
- •GI upset
- •Ulcers/rash
S for skin, sad and sperm
9
Q
what type of drug is Hydroxychloroquine
A
anti malarial
10
Q
adverse effects of Hydroxychloroquine
A
•Irreversible Retinopathy
- Corneal deposits
- Haemolytic anaemia
- GI upset
11
Q
mechanism of action of Leflunomide
A
inhibits dihydroorotate dehydrogenase
12
Q
main adverse effect of Leflunomide
A
interstitial lung disease
13
Q
what is another name for IM gold
A
Sodium aurothiomalate
14
Q
how is gold given
A
IM
15
Q
adverse effects of IM gold
A
- bone marrow suppression
- stop drug until platelets etc recover
- glomerulonephritis
- rash
- mouth ulcers
