Rheumatoid Arthritis Flashcards
Ibuprofen
Non-Selective NSAID
- Inhibit COX-1/COX-2
–> Prevent conversion of arachidonic acid to prostaglandin
COX-1: Reversible Inhibition
COX-2: Weak Inhibition
Celecoxib
COX-2 Selective NSAID
- Inhibit COX-1/COX-2
–> Prevent conversion of arachidonic acid to prostaglandin
COX-2: 10-20x more active than COX-1
Rofecoxib
COX-2 Selective NSAID
- Inhibit COX-1/COX-2
–> Prevent conversion of arachidonic acid to prostaglandin
COX-2: 10-20x more active than COX-1
Valdecoxib
COX-2 Selective NSAID
- Inhibit COX-1/COX-2
–> Prevent conversion of arachidonic acid to prostaglandin
COX-2: 10-20x more active than COX-1
Aspirin
COX-1 Selective NSAID
- Inhibit COX-1/COX-2
–> Prevent conversion of arachidonic acid to prostaglandin
COX-1: Weakly COX-1 Selective
Paracetamol
COX-1 Selective NSAID
- Inhibit COX-1/COX-2/COX-3
–> Prevent conversion of arachidonic acid to prostaglandin
Methotrexate
DMARD
- Anti-inflammatory Action
Folate Antagonist, interferes with thymidylate synthesis
- Interferes with DNA synthesis
Sulfasalazine
DMARD
- Anti-inflammatory Action
Releases salicylic acid in colon
- Produces anti-inflammatory effects
Leflunomide
DMARD
- Produces metabolite that inhibits Dihydroorotate Dehydrogenase
Results in inhibition of:
- T-Cell Proliferation
- B-Cell Production of autoantibodies
Tofacitinib
DMARD (Targeted Synthetic)
- Inhibit JAK
Infliximab
DMARD (Biologic)
- Blocks TNF-Alpha
Adalimumab
DMARD (Biologic)
- Blocks TNF-Alpha
Etanercept
DMARD (Biologic)
- Blocks TNF-Alpha
Colchicine
Inhibits Inflammation through multiple methods
- Inhibit Microtubule assembly
- Inhibit Neutrophils
- Prevent Interleukin-1 Beta activation
- Inhibit response to urate crystals
- Intterrupt mast cell degranulation
Treats Crystal Associated Arthritis (Gout)
Probenecid
Enhances Uric Acid secretions
- Lowers Uric Acid levels in blood
Well tolerated
