Renal 1 Flashcards
Aldosterone
Primary Endogenous Mineralocorticoid that activates gene expression of Na+/K+ channels
- Increase Na+ reabsorption
- Increase K+ and H+ excretion
Vasopressin
Controls water reabsorption in collecting duct
Furosemide
Loop Diuretic
- Inhibits Na+/K+/2CL- co-transporter on the luminal membrane (Thick Ascending Limb of Loop of Henle)
Water and ions stay in lumen and are not reabsorbed
Most powerful diuretic
Bumetanide
Loop Diuretic
- Inhibits Na+/K+/2CL- co-transporter on the luminal membrane (Thick Ascending Limb of Loop of Henle)
Water and ions stay in lumen and are not reabsorbed
Most powerful diuretic
Bendroflumethiazide
Thiazide
- Binds to Cl- site of Na+/Cl- co-transports on the Distal Tubule
- Increases renin secretion
- Increases natriuresis (Na+ loss)
- Reduces Ca2+ excretion
Hydrochlorothiazide
Thiazide
- Binds to Cl- site of Na+/Cl- co-transports on the Distal Tubule
- Increases renin secretion
- Increases natriuresis (Na+ loss)
- Reduces Ca2+ excretion
Chlortalidone
Lacks Thiazide loop but has Thiazide effects
- Binds to Cl- site of Na+/Cl- co-transports on the Distal Tubule
- Increases renin secretion
- Increases natriuresis (Na+ loss)
- Reduces Ca2+ excretion
Indapamide
Lacks Thiazide loop but has Thiazide effects
- Binds to Cl- site of Na+/Cl- co-transports on the Distal Tubule
- Increases renin secretion
- Increases natriuresis (Na+ loss)
- Reduces Ca2+ excretion
Metolazone
Lacks Thiazide loop but has Thiazide effects
- Binds to Cl- site of Na+/Cl- co-transports on the Distal Tubule
- Increases renin secretion
- Increases natriuresis (Na+ loss)
- Reduces Ca2+ excretion
Spironolactone
Potassium Sparing Diuretics
(Aldosterone Competitive Antagonist)
- Inhibits distal Na+ retention and K+ secretion
- Targets the Collecting Tubule
Causes Specific Adverse Effects:
- Gynecomastia, Menstrual Disorders, Testicular Atrophy
Combined with Loop Diuretic/Thiazide to prevent Hypokalemia
Eplerenone
Potassium Sparing Diuretics
(Aldosterone Competitive Antagonist)
- Inhibits distal Na+ retention and K+ secretion
- Targets the Collecting Tubule
Combined with Loop Diuretic/Thiazide to prevent Hypokalemia
Triamterene
Other Diuretic
Inhibits Na+ reabsorption of the collecting tubule
- Block lumenal Na+ channels that are regulated by aldosterone
Amiloride
Other Diuretic
Inhibits Na+ reabsorption of the collecting tubule
- Block lumenal Na+ channels that are regulated by aldosterone
Mannitol
Osmotic Diuretic
- Increases the osmotic pressure of all parts of the nephron permeable by water
(Proximal Tubule, Loop of Henle, Distal Tubule, Collecting Tubule)
- Decrease reabsorption
