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PHARM 243 (Midterm 2) - Drugs > Anemia > Flashcards

Anemia Flashcards

1
Q

Iron

A

Hematinic Agent
- Ferric Iron (Fe3+)
- Ferrous Iron (Fe2+) (Better absorbed, is absorbed in the duodenum)

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2
Q

Ferrous Sulfate

A

Hematinic Agent
- Highest Source of Elemental Iron

Oral

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3
Q

Ferrous Fumarate

A

Hematinic Agent
- 2nd Highest Source of Elemental Iron

Oral

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4
Q

Ferrous Gluconate

A

Hematinic Agent

Oral

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5
Q

Polysaccharide-Iron Complex

A

Hematinic Agent

Oral

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6
Q

Iron Dextran

A

Hematinic Agent

IV

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7
Q

Sodium Ferric Gluconate

A

Hematinic Agent

Iron formulation IV

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8
Q

Iron Sucrose

A

Hematinic Agent

IV

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9
Q

Folic Acid
- Affects what?

A

Vitamin B9 (Hematinic Agent)
- Needed for DNA synthesis (Purines, Pyrimidines, Amino Acids)

Lack of B9 affects cells that actively divide
- Bone Marrow Cells are affected which are needed for erythropoiesis (RBC Production)

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10
Q

Cyanocobalamin
- Affects what?

A

Vitamin B12 (Hematinic Agent)
- Needed for DNA synthesis (Purines, Pyrimidines, Amino Acids)

Lack of B9 affects:

Cells that actively divide
- Bone Marrow Cells are affected which are needed for erythropoiesis (RBC Production)

Abnormal DNA replication
- RBC do not mature properly , produces megaloblasts that not leave the marrow or dysfunctional RBC that do leave the marrow

Nervous System
- Causes inflammation, demyelination, and neuronal cell death

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11
Q

Hydroxocobalamin

A

Vitamin B12 (Hematinic Agent)
- Needed for DNA synthesis (Purines, Pyrimidines, Amino Acids)

Lack of B9 affects:
Cells that actively divide
- Bone Marrow Cells are affected which are needed for erythropoiesis (RBC Production)

Abnormal DNA replication
- RBC do not mature properly , produces megaloblasts that not leave the marrow or dysfunctional RBC that do leave the marrow

Nervous System
- Causes inflammation, demyelination, and neuronal cell death

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12
Q

Epoetin Alpa

A

Erythropoietin (Hematopoietic Growth Factor)
- Stimulates production of RBC

IV/SC

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13
Q

Darbepoetin Alpha

A

Synthetic Erythropoietin (Hematopoietic Growth Factor)
- Stimulates production of RBC

Longer Half Life

Can cause seizures to patients on dialysis

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14
Q

Filgrastim

A

Granulocyte Colony-Stimulating Factors (Hematopoietic Growth Factor)

G-CSF
- Binds to Myeloid Progenitor Cells (Bone Marrow Cells that make RBC, Granulocytes, etc.)
–> Affects JAK/STAT pathway to stimulate proliferation/differentiation of neutrophils

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15
Q

Lenograstim

A

Granulocyte Colony-Stimulating Factors (Hematopoietic Growth Factor)

G-CSF
- Binds to Myeloid Progenitor Cells (Bone Marrow Cells that make RBC, Granulocytes, etc.)
–> Affects JAK/STAT pathway to stimulate proliferation/differentiation of neutrophils

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16
Q

Pegfilgrastim

A

Granulocyte Colony-Stimulating Factors (Hematopoietic Growth Factor)

G-CSF
- Binds to Myeloid Progenitor Cells (Bone Marrow Cells that make RBC, Granulocytes, etc.)
–> Affects JAK/STAT pathway to stimulate proliferation/differentiation of neutrophils

17
Q

Sargramostim

A

Granulocyte Colony-Stimulating Factors (Hematopoietic Growth Factor)

GM-CSF
- Binds to Myeloid Progenitor Cells (Bone Marrow Cells that make RBC, Granulocytes, etc.)
–> Affects JAK/STAT pathway to stimulate proliferation/differentiation of neutrophils and monocytes
–> Also stimulates the actions of neutrophils, monocytes, and eosinophils

18
Q

Oprelvekin

A

Hematopoietic Growth Factors: Megakaryocyte (Thrombopoietic) Growth Factor

AKA: IL-11

  • Stimulate growth of megakaryocytic progenitors
  • Increase number of platelets

Associated with dizziness, headache, and fatigue

19
Q

Thrombopoietin

A

Hematopoietic Growth Factors: Megakaryocyte (Thrombopoietic) Growth Factor
- Stimulate growth of megakaryocytic progenitors
- Increase number of platelets

20
Q

Eltrombopag

A

Oral Thrombopoietin Agonist
- Increase number of platelets

21
Q

Romiplostim

A

Injectable Thrombopoietin Agonist
- Increase number of platelets

PHARM 243 (Midterm 2) - Drugs (11 decks)

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