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PHARM 243 (Midterm 2) - Drugs > Endocrine 5 (Disorders) > Flashcards

Endocrine 5 (Disorders) Flashcards

1
Q

Somatropin

A

Recombinant Growth Hormone
- Stimulates Hepatic Production of IGF
- Stimulates Growth

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2
Q

Mecasermin

A

Recombinant IGF
- Promotes uptake of amino acids
- Promotes protein synthesis

Affecting Skeletal Muscle and Cartilage of Long Bone

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3
Q

IGF-1

A

Insulin-Like Growth Factor
- Bind to IGF-1 Receptors to stimulate Cell Growth

Two Pathways
- Activation of Ras –> Activation of MEK –> Self-Proliferation
- Activation of Akt –> Activation of mTOR –> Stimulates Protein synthesis

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4
Q

Pegvisomant

A

Growth Hormone Receptor Antagonist
- Competitive Antagonist of GH
- Prevents GH from acting on liver receptors, preventing IGF secretion

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5
Q

Octreotide

A

Somatostatin Analogues
- Mimics action of somatostatin and inhibits Pituitary Gland
- Inhibits GH secretion

Octreotide inhibits Somatostatin Receptors 2 and 5

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6
Q

Lanreotide

A

Somatostatin Analogues
- Mimics action of somatostatin and inhibits Pituitary Gland
- Inhibits GH secretion

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7
Q

Pasireotide

A

Somatostatin Analogues
- Mimics action of somatostatin and inhibits Pituitary Gland
- Inhibits GH secretion

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8
Q

Testosterone

A

Acts on Androgen Receptors (Nuclear Receptor Signalling)
- Maturation of reproductive organs
- Development of secondary sexual characteristics
- Maintenance of spermatogenesis and maturation of spermatozoa

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9
Q

FSH

A

Follicle Stimulating Hormone
- Stimulates spermatogenesis and maturation of spermatozoa

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10
Q

ICSH

A

Interstitial Cell Stimulating Hormone
- Maturation of reproductive organs
- Development of secondary sexual characteristics
- Testes secrete testosterone

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11
Q

Gonadorelin

A

Pulse Administration:
- Secretion of LH and FSH

Chronic Administration
1. Down regulation of receptors in anterior pituitary
2. Inhibition of LH and FSH
3. Suppression of testicular steroidogenesis due to decreased LH and FSH

Result: Decrease in Testosterone

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12
Q

Buserelin

A

Pulse Administration:
- Secretion of LH and FSH

Chronic Administration
1. Down regulation of receptors in anterior pituitary
2. Inhibition of LH and FSH
3. Suppression of testicular steroidogenesis due to decreased LH and FSH

Result: Decrease in Testosterone

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13
Q

Leuprorelin

A

Pulse Administration:
- Secretion of LH and FSH

Chronic Administration
1. Down regulation of receptors in anterior pituitary
2. Inhibition of LH and FSH
3. Suppression of testicular steroidogenesis due to decreased LH and FSH

Result: Decrease in Testosterone

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14
Q

Goserelin

A

Pulse Administration:
- Secretion of LH and FSH

Chronic Administration
1. Down regulation of receptors in anterior pituitary
2. Inhibition of LH and FSH
3. Suppression of testicular steroidogenesis due to decreased LH and FSH

Result: Decrease in Testosterone

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15
Q

Nafarelin

A

Pulse Administration:
- Secretion of LH and FSH

Chronic Administration
1. Down regulation of receptors in anterior pituitary
2. Inhibition of LH and FSH
3. Suppression of testicular steroidogenesis due to decreased LH and FSH

Result: Decrease in Testosterone

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16
Q

Degarelix

A

Reversibly binds GnRH receptor in anterior pituitary and blocks it
- Decrease LH and FSH resulting in decreased testosterone

More rapid acting
Does not cause transient testosterone surge

17
Q

Bicalutamide

A

Competitive Antagonist of Androgens
- Binds to androgen receptors on target tissue and inhibits androgen action
- Controls testosterone surges caused by GnRH analogues
–> Combine with GnRH analogues

Result: Inhibits Androgen Action to control testosterone flares

18
Q

Enzalutamide

A

Competitive Antagonist of Androgens
- Binds to androgen receptors on target tissue and inhibits androgen action
- Controls testosterone surges caused by GnRH analogues
–> Combine with GnRH analogues

Result: Inhibits Androgen Action to control testosterone flares

19
Q

Flutamide

A

Competitive Antagonist of Androgens
- Binds to androgen receptors on target tissue and inhibits androgen action
- Controls testosterone surges caused by GnRH analogues
–> Combine with GnRH analogues

Result: Inhibits Androgen Action to control testosterone flares

20
Q

Nilutamide

A

Competitive Antagonist of Androgens
- Binds to androgen receptors on target tissue and inhibits androgen action
- Controls testosterone surges caused by GnRH analogues
–> Combine with GnRH analogues

Result: Inhibits Androgen Action to control testosterone flares

21
Q

Cyproterone

A

Competitive Antagonist of Androgens
- Binds to androgen receptors on target tissue and inhibits androgen action
- Controls testosterone surges caused by GnRH analogues
–> Combine with GnRH analogues

Result: Inhibits Androgen Action to control testosterone flares

22
Q

Abiraterone

A

Selectivity inhibits CYP17
- Enzyme needed for androgen biosynthesis in testicular, adrenal, and prostatic tumour tissues

Result: Decreases androgen in prostate tissue

23
Q

Finasteride

A

Inhibits 5alpha-Reductase
- Prevents conversion of testosterone into the more potent dihydrotestosteron
- Treats benign prostatic hyperplasia

Result: Prevent formation of powerful testosterone, preventing inhibition of hair growth

24
Q

Minoxidil

A

Hair follicles convert it into Minoxidil Sulfate
- Potent vasodilator that increases blood supply to hair follicles

Result: Stimulates growth of new hair follicles

25
Q

Eflornithine

A

Inhibits Ornithine decarboxylase in hair follicles
- Reduced cell replication
- Reduced growth of new hair follicles

May cause acne

26
Q

Bromocriptine

A

Acts as Dopamine D2 Receptor Agonists
- Inhibits anterior pituitary from releasing prolactin
- Inhibits lactation

27
Q

Cabergoline

A

Acts as Dopamine D2 Receptor Agonists
- Inhibits anterior pituitary from releasing prolactin
- Inhibits lactation

28
Q

Quinagolide

A

Acts as Dopamine D2 Receptor Agonists
- Inhibits anterior pituitary from releasing prolactin
- Inhibits lactation

PHARM 243 (Midterm 2) - Drugs (11 decks)

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