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PHARM 243 (Midterm 2) - Drugs > Bone Disorders > Flashcards

Bone Disorders Flashcards

1
Q

Alendronate

A

Aminobisphosphonates
- Inhibits Osteoclast Activity

Disrupts Mevalonate pathway leading to disruption of osteoclast activity, leading to apoptosis of osteoclasts

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2
Q

Risedronate

A

Aminobisphosphonates
- Inhibits Osteoclast Activity

Disrupts Mevalonate pathway leading to disruption of osteoclast activity, leading to apoptosis of osteoclasts

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3
Q

Pamidronate

A

Aminobisphosphonates
- Inhibits Osteoclast Activity

Disrupts Mevalonate pathway leading to disruption of osteoclast activity, leading to apoptosis of osteoclasts

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4
Q

Zoledronate

A

Aminobisphosphonates
- Inhibits Osteoclast Activity

Disrupts Mevalonate pathway leading to disruption of osteoclast activity, leading to apoptosis of osteoclasts

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5
Q

Etidronate

A

Non-Aminobisphosphonates
- Inhibits Osteoclast Activity

Increases accumulation of cytotoxic metabolites within osteoclasts, leading to osteoclast cell death

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6
Q

Clodronate

A

Non-Aminobisphosphonates
- Inhibits Osteoclast Activity

Increases accumulation of cytotoxic metabolites within osteoclasts, leading to osteoclast cell death

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7
Q

Raloxifene

A

Selective Estrogen Receptor Modulators (SERM)
- Stimulates Osteoblasts
- Inhibits Osteoclasts

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8
Q

Teriparatide

A

PTH
- Increases Serum Calcium
- Decreased Serum Phosphate
- Indirect: Increased RANKL = Increase Osteoclast activity

Low Intermittent Dose:
- Increase Osteoblasts
- Inhibit apoptosis of Osteoblast
- Stimulate IGF (Promotes Bone Formation)
- Kidney Effects:
–> Increased Ca2+ and Mg2+ reabsorption
–> Decreased Phosphate, amino acids, bicarbonate, Na+, Cl-. and Sulfate reabsorption
–> Stimulation of Vitamin D production

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9
Q

Calcitriol

A

Vitamin D

  • Increases Calcium absorption/reabsorption
  • Stimulates Osteoblast/Osteoclast
  • Decreases PTH
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10
Q

Ergocalciferol

A

Vitamin D

  • Increases Calcium absorption/reabsorption
  • Stimulates Osteoblast/Osteoclast
  • Decreases PTH
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11
Q

Calcipotriene

A

Vitamin D

  • Increases Calcium absorption/reabsorption
  • Stimulates Osteoblast/Osteoclast
  • Decreases PTH
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12
Q

Doxercalciferol

A

Vitamin D

  • Increases Calcium absorption/reabsorption
  • Stimulates Osteoblast/Osteoclast
  • Decreases PTH
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13
Q

Paricalcitol

A

Vitamin D

  • Increases Calcium absorption/reabsorption
  • Stimulates Osteoblast/Osteoclast
  • Decreases PTH
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14
Q

Denosumab

A

Inhbibits RANKL
- Prevents RANK (On osteoblasts) from binding to RANKL (On osteoclasts)
- Prevents differentiation, activation, and survival of Osteoclasts

Decreased Bone Resorption

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15
Q

Salcatonin

A

Calcitonin
- Decreases reabsorption of calcium and phosphate in the kidney
- Inhibits osteoclast activity
–> Inhibits bone resorption

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16
Q

Calcium Carbonate and etc.

A

Essential nutrient, improves muscles and strength of bones

Vitamin D helps to increase absorption of calcium

Calcium Carbonate contains the most calcium

PHARM 243 (Midterm 2) - Drugs (11 decks)

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